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> Protein (NX_O60662)
Protein (NX_O60662)
Protein
Gene SymbolKLHL41 to neXtProt (NX_O60662)
DescriptionKelch-like protein 41
Chromosome2
Location2q31.1 (170366212 ~ 170382772) to Ensembl
Sequene Features : Isoforms 2, Variants 21, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of skeletal muscle cell differentiation
.regulation of myoblast proliferation
.skeletal muscle fiber development
  + 7 more...
.N/A .sarcoplasmic reticulum membrane
.Cul3-RING ubiquitin ligase complex
.M band
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 21 1
2014-09-19protein level
2 49 1
2014-05-27protein level
2 49 1
2014-02-25protein level
2 49 1
2013-12-09protein level
2 41 1
2013-11-01protein level
2 40 0
2013-09-12protein level
2 40 0
2013-08-17protein level
2 40 0
2013-07-15protein level
2 30 0
2013-06-11protein level
2 30 0
2013-02-12protein level
2 13 0
2012-12-20protein level
2 12 0
2012-10-30protein level
2 15 0
2012-10-07protein level
2 15 0
2012-08-24protein level
2 15 0
2012-07-28protein level
2 15 0
2012-06-08protein level
2 19 0
2012-05-07protein level
2 16 0
2012-04-10protein level
2 16 0
2012-01-13protein level
2 13 0
2011-12-20protein level
2 13 0
2011-11-11protein level
2 13 0
2011-08-23protein level
2 13 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60662-1
0 25 0 67993.7106
NX_O60662-2
0 25 0 66823.1622
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-5353084,EBI-1049657 NEB  
  .regulation of actin filament length
.muscle filament sliding
.somatic muscle development
.muscle organ development
.structural constituent of muscle .extracellular exosome
.Z disc
.actin cytoskeleton
.cytosol
2 EBI-5353084,EBI-947779 RCHY1  
  .error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain4
connective tissue6
ear62
embryonic tissue42
eye19
heart1273
kidney23
larynx127
liver63
lung50
mammary gland13
mouth1315
muscle1927
nerve193
pancreas65
pharynx24
placenta10
prostate131
testis9
thymus12
trachea57
Health State
TissuesTPM*
normal139
breast (mammary gland) tumor21
germ cell tumor7
head and neck tumor67
kidney tumor72
soft tissue/muscle tissue tumor71
Developmental Stage
TissuesTPM*
adult43
fetus143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
esophagus77.6
gallbladder7.6
heart muscle78.1
lung1.2
pancreas1.1
prostate89.9
skin1.1
testis2.2
urinary bladder4.8
Tissues
TissuesExpression level
heart muscleLow
lungLow
skeletal muscleHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607701, gene) Kelch repeat and btb/poz domains-containing protein 10; KBTBD10OMIM


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