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> Protein (NX_O60671)
Protein (NX_O60671)
Protein
Gene SymbolRAD1 to neXtProt (NX_O60671)
DescriptionCell cycle checkpoint protein RAD1
Chromosome5
Location5p13.2 (34905369 ~ 34919094) to Ensembl
Sequene Features : Isoforms 3, Variants 30, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nucleic acid phosphodiester bond hydrolysis
.cellular response to ionizing radiation
.meiotic recombination checkpoint
  + 5 more...
.exodeoxyribonuclease III activity
.3'-5' exonuclease activity
.damaged DNA binding
.intracellular membrane-bounded organelle
.checkpoint clamp complex
.chromosome
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 30 1
2014-09-19protein level
3 25 1
2014-05-27protein level
3 25 1
2014-02-25protein level
3 25 1
2013-12-09protein level
3 18 1
2013-11-01protein level
3 18 1
2013-09-12protein level
3 18 1
2013-08-17protein level
3 18 1
2013-07-15protein level
3 15 0
2013-06-11protein level
3 15 0
2013-02-12protein level
3 7 0
2012-12-20protein level
3 7 0
2012-10-30protein level
3 8 0
2012-10-07protein level
3 8 0
2012-08-24protein level
3 8 0
2012-07-28protein level
3 8 0
2012-06-08protein level
3 10 0
2012-05-07protein level
3 10 0
2012-04-10protein level
3 10 0
2012-01-13protein level
3 11 0
2011-12-20protein level
3 11 0
2011-11-11protein level
3 11 0
2011-08-23protein level
3 11 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60671-1
3 11 0 31806.519
NX_O60671-2
1 11 0 27809.4931
NX_O60671-3
1 2 0 7570.8586
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-721835,EBI-1056174 HUS1  
  .cellular response to ionizing radiation
.meiotic DNA integrity checkpoint
.mitotic DNA replication checkpoint
  + 12 more...
.N/A .site of double-strand break
.checkpoint clamp complex
.cytoplasm
  + 3 more...
2 EBI-721835,EBI-2606224 RAD9A  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.nucleic acid phosphodiester bond hydrolysis
.cellular response to ionizing radiation
  + 6 more...
.histone deacetylase binding
.protein kinase binding
.enzyme binding
  + 3 more...
.checkpoint clamp complex
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder167
blood32
bone97
bone marrow41
brain11
cervix144
connective tissue13
ear62
embryonic tissue42
esophagus49
eye43
intestine34
kidney66
larynx42
liver29
lung26
lymph node66
mammary gland39
muscle47
nerve64
ovary49
pancreas74
pharynx73
pituitary gland60
placenta42
prostate36
salivary gland246
skin9
spleen56
stomach41
testis36
thymus25
thyroid21
trachea19
uterus30
Health State
TissuesTPM*
normal34
adrenal tumor79
bladder carcinoma284
breast (mammary gland) tumor64
cervical tumor144
chondrosarcoma60
colorectal tumor35
esophageal tumor57
gastrointestinal tumor50
germ cell tumor41
glioma37
head and neck tumor14
kidney tumor72
leukemia42
liver tumor10
lung tumor9
lymphoma69
ovarian tumor65
pancreatic tumor57
primitive neuroectodermal tumor of the CNS23
prostate cancer48
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor23
uterine tumor33
Developmental Stage
TissuesTPM*
adult34
embryoid body14
blastocyst65
fetus35
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.1
adrenal gland19.3
appendix14.4
bone marrow12.6
cerebral cortex11.1
colon10.2
duodenum9.8
esophagus11.4
gallbladder11.3
heart muscle16.8
kidney11.6
liver7
lung14.4
lymph node18.7
ovary11.2
pancreas3.9
placenta19.2
prostate14
salivary gland7.9
skin9.6
small intestine9.5
spleen9.3
stomach10.8
testis20.6
thyroid gland12.7
urinary bladder14.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603153, gene) Rad1, s. pombe, homolog of; RAD1OMIM


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