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> Protein (NX_O60674)
Protein (NX_O60674)
Protein
Gene SymbolJAK2 to neXtProt (NX_O60674)
DescriptionTyrosine-protein kinase JAK2
Chromosome9
Location9p24.1 (4985033 ~ 5128183) to Ensembl
Sequene Features : Isoforms 1, Variants 232, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
.response to interleukin-12
  + 76 more...
.histone binding
.SH2 domain binding
.histone kinase activity (H3-Y41 specific)
  + 9 more...
.membrane raft
.endosome lumen
.extrinsic component of cytoplasmic side of plasma membrane
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 232 10
2014-09-19protein level
1 195 10
2014-05-27protein level
1 195 10
2014-02-25protein level
1 102 10
2013-12-09protein level
1 84 10
2013-11-01protein level
1 84 10
2013-09-12protein level
1 84 11
2013-08-17protein level
1 84 11
2013-07-15protein level
1 84 11
2013-06-11protein level
1 84 11
2013-02-12protein level
1 84 11
2012-12-20protein level
1 84 11
2012-10-30protein level
1 85 11
2012-10-07protein level
1 85 11
2012-08-24protein level
1 85 11
2012-07-28protein level
1 85 11
2012-06-08protein level
1 30 11
2012-05-07protein level
1 29 11
2012-04-10protein level
1 29 11
2012-01-13protein level
1 22 11
2011-12-20protein level
1 22 11
2011-11-11protein level
1 22 11
2011-08-23protein level
1 22 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60674-1
56 0 1 130589.409
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-518647,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-518647,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
3 EBI-518647,EBI-1809771 CSF2RB  
  .interleukin-3-mediated signaling pathway
.interleukin-5-mediated signaling pathway
.cellular response to interleukin-3
  + 3 more...
.cytokine receptor activity
.receptor activity
.granulocyte macrophage colony-stimulating factor receptor complex
.integral component of plasma membrane
.plasma membrane
4 EBI-518647,EBI-6511486 MPL  
  .homeostasis of number of cells
.thrombopoietin-mediated signaling pathway
.regulation of chemokine production
  + 4 more...
.thrombopoietin receptor activity
.transmembrane signaling receptor activity
.cell surface
.integral component of plasma membrane
.plasma membrane
.Golgi apparatus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bone13
bone marrow164
brain8
connective tissue6
eye4
intestine8
kidney9
liver9
lung11
lymph node44
mammary gland6
muscle65
ovary29
pancreas18
placenta17
prostate5
skin4
spleen18
stomach10
testis9
thymus12
trachea19
uterus17
vascular77
Health State
TissuesTPM*
normal14
chondrosarcoma12
colorectal tumor17
gastrointestinal tumor8
germ cell tumor3
kidney tumor14
leukemia52
liver tumor10
lung tumor9
non-neoplasia10
ovarian tumor26
pancreatic tumor38
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult11
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.9
adrenal gland9.5
appendix21.2
bone marrow12.8
cerebral cortex5.7
colon7.4
duodenum6.6
esophagus11.1
gallbladder14.5
heart muscle24.9
kidney6.9
liver3
lung10.8
lymph node21.2
ovary11.8
pancreas1.9
placenta10.1
prostate7.7
salivary gland3.3
skin9.7
small intestine8.8
spleen18.1
stomach14.1
testis10.6
thyroid gland5.8
urinary bladder13.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*147796, gene) Janus kinase 2; JAK2OMIM
2(#254450, phenotype) MyelofibrosisOMIM
3(#263300, phenotype) Polycythemia veraOMIM
4(#600880, phenotype) Budd-chiari syndrome; BDCHSOMIM
5(#601626, phenotype) Leukemia, acute myeloid; AMLOMIM
6(#614521, phenotype) Thrombocythemia 3; THCYT3OMIM
7acute lymphocytic leukemia;acute myelogenous leukemia;Myeloproliferative disorder;chronic myeloid leukemiaCGP


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