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> Protein (NX_O60880)
Protein (NX_O60880)
Protein
Gene SymbolSH2D1A to neXtProt (NX_O60880)
DescriptionSH2 domain-containing protein 1A
ChromosomeX
LocationXq25 (123480194 ~ 123507005) to Ensembl
Sequene Features : Isoforms 6, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of natural killer cell mediated cytotoxicity
.positive regulation of signal transduction
.cell-cell signaling
  + 2 more...
.SH3/SH2 adaptor activity .cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 54 1
2014-09-19protein level
6 48 1
2014-05-27protein level
6 45 1
2014-02-25protein level
6 45 1
2013-12-09protein level
6 43 1
2013-11-01protein level
6 43 1
2013-09-12protein level
6 43 1
2013-08-17protein level
6 43 1
2013-07-15protein level
6 33 1
2013-06-11protein level
6 33 1
2013-02-12protein level
6 25 2
2012-12-20protein level
6 25 2
2012-10-30protein level
6 25 2
2012-10-07protein level
6 25 1
2012-08-24protein level
6 25 1
2012-07-28protein level
6 25 1
2012-06-08protein level
6 21 1
2012-05-07protein level
6 21 1
2012-04-10protein level
6 21 1
2012-01-13protein level
6 21 1
2011-12-20protein level
6 21 1
2011-11-11protein level
6 21 1
2011-08-23protein level
6 21 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60880-1
1 6 0 14178.2402
NX_O60880-2
1 3 0 8387.1325
NX_O60880-3
1 2 0 6280.2196
NX_O60880-4
0 6 0 13919.1241
NX_O60880-5
2 3 0 8183.1757
NX_O60880-6
1 3 0 6626.2841
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6983382,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
2 EBI-6983382,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
3 EBI-6983382,EBI-603457 TNK2  
  .regulation of clathrin-mediated endocytosis
.positive regulation of peptidyl-tyrosine phosphorylation
.innate immune response
  + 10 more...
.hormone receptor binding
.WW domain binding
.metal ion binding
  + 8 more...
.Grb2-EGFR complex
.neuronal cell body
.extrinsic component of cytoplasmic side of plasma membrane
  + 12 more...
4 EBI-6983382,EBI-4315002 SLAMF1  
  .regulation of catalytic activity
.lymphocyte activation
.regulation of vesicle fusion
  + 3 more...
.transmembrane signaling receptor activity
.antigen binding
.extracellular exosome
.phagocytic vesicle
.integral component of membrane
.external side of plasma membrane
5 EBI-6983382,EBI-717515 ARHGEF7  
  .positive regulation of lamellipodium morphogenesis
.positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
  + 14 more...
.protein kinase binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.protein complex
.neuronal cell body
.neuron projection
  + 5 more...
6 EBI-6983382,EBI-1642523 ARHGEF6  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.neurotrophin TRK receptor signaling pathway
  + 7 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.lamellipodium
.cell-cell junction
.cytosol
.intracellular
7 EBI-6983382,EBI-2865388 LHX4  
  .negative regulation of apoptotic process
.medial motor column neuron differentiation
.organ morphogenesis
  + 4 more...
.sequence-specific DNA binding
.zinc ion binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood73
bone marrow41
kidney4
liver4
lung20
mammary gland6
pharynx24
prostate5
spleen18
testis4
thymus501
uterus8
Health State
TissuesTPM*
normal8
breast (mammary gland) tumor10
germ cell tumor3
leukemia52
liver tumor10
uterine tumor11
Developmental Stage
TissuesTPM*
adult2
fetus21
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.2
appendix9.7
bone marrow3.5
colon1.3
esophagus1.4
gallbladder4.3
liver1
lung3.1
lymph node32.8
salivary gland1.2
small intestine1.7
spleen10.7
stomach2.8
urinary bladder7
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*300490, gene) Sh2 domain protein 1a; SH2D1AOMIM
2(#308240, phenotype) Lymphoproliferative syndrome, x-linked, 1; XLP1OMIM


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