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> Protein (NX_O60885)
Protein (NX_O60885)
Protein
Gene SymbolBRD4 to neXtProt (NX_O60885)
DescriptionBromodomain-containing protein 4
Chromosome19
Location19p13.12 (15347647 ~ 15443356) to Ensembl
Sequene Features : Isoforms 3, Variants 150, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of DNA damage checkpoint
.regulation of phosphorylation of RNA polymerase II C-terminal domain
.regulation of inflammatory response
  + 15 more...
.lysine-acetylated histone binding
.chromatin binding
.DNA binding
.p53 binding
.positive transcription elongation factor complex b
.cytoplasm
.chromosome
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 150 17
2014-09-19protein level
3 113 17
2014-05-27protein level
3 113 17
2014-02-25protein level
3 113 17
2013-12-09protein level
3 81 16
2013-11-01protein level
3 73 15
2013-09-12protein level
3 73 16
2013-08-17protein level
3 73 16
2013-07-15protein level
2 41 10
2013-06-11protein level
2 41 10
2013-02-12protein level
2 15 16
2012-12-20protein level
2 15 16
2012-10-30protein level
2 17 16
2012-10-07protein level
2 17 10
2012-08-24protein level
2 12 10
2012-07-28protein level
2 12 10
2012-06-08protein level
2 12 10
2012-05-07protein level
2 12 10
2012-04-10protein level
2 12 10
2012-01-13protein level
2 10 10
2011-12-20protein level
2 10 10
2011-11-11protein level
2 10 8
2011-08-23protein level
2 10 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60885-1
19 23 6 152123.5083
NX_O60885-2
1 23 6 80412.6635
NX_O60885-3
3 23 6 88233.2512
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-723869,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-9345088,EBI-302023 HIST2H4A  
  .protein heterotetramerization
.negative regulation of gene expression, epigenetic
.negative regulation of megakaryocyte differentiation
  + 13 more...
.poly(A) RNA binding
.histone binding
.histone demethylase activity (H4-K20 specific)
.DNA binding
.extracellular exosome
.protein complex
.membrane
  + 5 more...
3 EBI-723869,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
4 EBI-723869,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
5 EBI-9345088,EBI-1797287 TWIST1  
  .positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
.cell proliferation involved in heart valve development
.negative regulation of double-strand break repair
  + 51 more...
.E-box binding
.bHLH transcription factor binding
.transcription factor binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
6 EBI-723869,EBI-8464037 JMJD6  
  .histone H4-R3 demethylation
.histone H3-R2 demethylation
.retina development in camera-type eye
  + 15 more...
.peptidyl-lysine 5-dioxygenase activity
.identical protein binding
.histone demethylase activity (H4-R3 specific)
  + 5 more...
.plasma membrane
.nucleolus
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder66
blood73
bone139
bone marrow20
brain56
cervix20
connective tissue67
embryonic tissue89
eye100
heart22
intestine103
kidney37
larynx127
liver151
lung101
lymph158
lymph node356
mammary gland105
mouth45
muscle94
nerve64
ovary147
pancreas98
pharynx49
pituitary gland60
placenta105
prostate68
salivary gland296
skin56
spleen18
testis71
thymus37
thyroid107
tonsil117
umbilical cord145
uterus77
Health State
TissuesTPM*
normal78
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor96
cervical tumor28
chondrosarcoma108
colorectal tumor124
gastrointestinal tumor16
germ cell tumor83
glioma139
head and neck tumor119
kidney tumor87
leukemia74
liver tumor239
lung tumor175
lymphoma110
non-neoplasia124
ovarian tumor118
pancreatic tumor66
primitive neuroectodermal tumor of the CNS55
prostate cancer67
retinoblastoma107
skin tumor47
soft tissue/muscle tissue tumor95
uterine tumor66
Developmental Stage
TissuesTPM*
adult80
embryoid body128
blastocyst65
neonate96
fetus84
infant127
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.4
adrenal gland15.4
appendix23.8
bone marrow15.8
cerebral cortex18.2
colon13.4
duodenum13
esophagus16.5
gallbladder16
heart muscle12.3
kidney16.2
liver13
lung17.1
lymph node21.2
ovary21.4
pancreas13.5
placenta33.2
prostate16.1
salivary gland13.4
skin19.3
small intestine16
spleen27.1
stomach17.4
testis30.5
thyroid gland17.6
urinary bladder15.6
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608749, gene) Bromodomain-containing protein 4; BRD4OMIM
2lethal midline carcinoma of young peopleCGP


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