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> Protein (NX_O60921)
Protein (NX_O60921)
Protein
Gene SymbolHUS1 to neXtProt (NX_O60921)
DescriptionCheckpoint protein HUS1
Chromosome7
Location7p12.3 (47735328 ~ 48019178) to Ensembl
Sequene Features : Isoforms 2, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to ionizing radiation
.meiotic DNA integrity checkpoint
.mitotic DNA replication checkpoint
  + 12 more...
.N/A .site of double-strand break
.checkpoint clamp complex
.cytoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 38 2
2014-09-19protein level
1 34 2
2014-05-27protein level
1 34 2
2014-02-25protein level
1 33 2
2013-12-09protein level
1 26 2
2013-11-01protein level
1 26 1
2013-09-12protein level
1 26 1
2013-08-17protein level
1 26 1
2013-07-15protein level
1 18 1
2013-06-11protein level
1 18 1
2013-02-12protein level
1 14 0
2012-12-20protein level
1 14 0
2012-10-30protein level
1 13 0
2012-10-07protein level
1 13 0
2012-08-24protein level
1 6 0
2012-07-28protein level
1 6 0
2012-06-08protein level
1 6 0
2012-05-07protein level
1 6 0
2012-04-10protein level
1 6 0
2012-01-13protein level
1 8 0
2011-12-20protein level
1 8 0
2011-11-11protein level
1 8 0
2011-08-23protein level
1 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60921-1
1 12 0 31670.3506
NX_O60921-2
0 12 0 29268.1113
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1056174,EBI-721835 RAD1  
  .nucleic acid phosphodiester bond hydrolysis
.cellular response to ionizing radiation
.meiotic recombination checkpoint
  + 5 more...
.exodeoxyribonuclease III activity
.3'-5' exonuclease activity
.damaged DNA binding
.intracellular membrane-bounded organelle
.checkpoint clamp complex
.chromosome
  + 2 more...
2 EBI-1056174,EBI-2606224 RAD9A  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.nucleic acid phosphodiester bond hydrolysis
.cellular response to ionizing radiation
  + 6 more...
.histone deacetylase binding
.protein kinase binding
.enzyme binding
  + 3 more...
.checkpoint clamp complex
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder100
blood32
bone69
bone marrow20
brain21
cervix20
connective tissue20
embryonic tissue9
eye9
intestine8
kidney14
liver14
lung23
lymph22
lymph node33
mammary gland13
muscle9
ovary9
pancreas9
parathyroid97
placenta10
prostate10
skin28
spleen93
stomach41
testis4
thymus25
thyroid64
trachea19
uterus17
vascular19
Health State
TissuesTPM*
normal20
bladder carcinoma113
cervical tumor28
chondrosarcoma36
colorectal tumor17
gastrointestinal tumor8
germ cell tumor45
glioma9
head and neck tumor22
leukemia21
liver tumor10
lung tumor29
lymphoma27
non-neoplasia20
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
retinoblastoma21
skin tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult13
blastocyst16
neonate32
fetus14
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.2
adrenal gland12.6
appendix12.3
bone marrow18.4
cerebral cortex8.1
colon13
duodenum9.4
esophagus11
gallbladder8.3
heart muscle12.1
kidney9.2
liver12.2
lung9
lymph node13
ovary9.1
pancreas5.3
placenta11.2
prostate9.9
salivary gland6.8
skin6.2
small intestine9.7
spleen9.8
stomach8.9
testis8.2
thyroid gland11.6
urinary bladder13
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastLow
bronchusLow
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusLow
fallopian tubeLow
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyLow
lateral ventricleMedium
lungMedium
lymph nodeMedium
nasopharynxLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleMedium
skin 1Low
skin 2Medium
small intestineLow
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603760, gene) Hydroxyurea-sensitive 1, s. pombe, homolog of; HUS1OMIM


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