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> Protein (NX_O60936)
Protein (NX_O60936)
Protein
Gene SymbolNOL3 to neXtProt (NX_O60936)
DescriptionNucleolar protein 3
Chromosome16
Location16q22.1 (67204057 ~ 67209643) to Ensembl
Sequene Features : Isoforms 3, Variants 31, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of extrinsic apoptotic signaling pathway
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.caspase binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.identical protein binding
  + 2 more...
.sarcoplasmic reticulum
.cytosol
.mitochondrion
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 31 2
2014-09-19protein level
3 17 2
2014-05-27protein level
3 17 2
2014-02-25protein level
2 17 2
2013-12-09protein level
2 8 2
2013-11-01protein level
2 7 2
2013-09-12protein level
2 7 2
2013-08-17protein level
2 6 2
2013-07-15protein level
2 3 2
2013-06-11protein level
2 3 2
2013-02-12protein level
2 3 0
2012-12-20protein level
2 4 0
2012-10-30protein level
2 4 0
2012-10-07protein level
2 4 0
2012-08-24protein level
2 4 0
2012-07-28protein level
2 4 0
2012-06-08protein level
2 4 0
2012-05-07protein level
2 3 0
2012-04-10protein level
2 3 0
2012-01-13protein level
2 0 0
2011-12-20protein level
2 3 0
2011-11-11protein level
2 3 0
2011-08-23protein level
2 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60936-1
5 5 0 24312.5112
NX_O60936-2
0 9 0 22615.6011
NX_O60936-3
4 8 0 29336.8189
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740992,EBI-78060 CASP8  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 55 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.cysteine-type endopeptidase activity involved in apoptotic process
.scaffold protein binding
  + 5 more...
.ripoptosome
.membrane raft
.cell body
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites125
blood8
bone83
brain25
cervix82
connective tissue20
embryonic tissue4
esophagus49
eye52
intestine43
kidney52
larynx85
liver14
lung20
mammary gland46
muscle65
nerve128
ovary9
pancreas70
parathyroid194
pituitary gland121
placenta28
prostate58
salivary gland197
skin37
stomach20
testis2
thyroid42
uterus38
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor75
chondrosarcoma36
colorectal tumor44
esophageal tumor57
gastrointestinal tumor50
germ cell tumor3
glioma27
head and neck tumor59
kidney tumor72
lung tumor19
non-neoplasia20
ovarian tumor13
pancreatic tumor66
primitive neuroectodermal tumor of the CNS7
prostate cancer28
skin tumor47
soft tissue/muscle tissue tumor39
uterine tumor44
Developmental Stage
TissuesTPM*
adult46
embryoid body14
fetus14
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.1
adrenal gland37
appendix7.7
cerebral cortex10.8
colon14
duodenum9
esophagus22.1
gallbladder16.9
heart muscle36.9
kidney12.7
liver10
lung26.4
lymph node4.6
ovary10.7
pancreas10.2
placenta18.5
prostate50.6
salivary gland28
skin65.8
small intestine10.9
spleen8.1
stomach24
testis6.1
thyroid gland21.4
urinary bladder14
Tissues
TissuesExpression level
adrenal glandHigh
appendixLow
breastLow
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeLow
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
pancreasMedium
parathyroid glandHigh
placentaLow
prostateHigh
rectumLow
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Medium
soft tissue 1Low
soft tissue 2Low
stomach 1Low
stomach 2Low
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605235, gene) Nucleolar protein 3; NOL3OMIM


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