Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_O60941)
Protein (NX_O60941)
Protein
Gene SymbolDTNB to neXtProt (NX_O60941)
DescriptionDystrobrevin beta
Chromosome2
Location2p23.3 (25600067 ~ 25896503) to Ensembl
Sequene Features : Isoforms 7, Variants 74, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .zinc ion binding .synapse
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 74 3
2014-09-19protein level
7 57 3
2014-05-27protein level
7 57 4
2014-02-25protein level
7 57 4
2013-12-09protein level
7 37 4
2013-11-01protein level
7 37 4
2013-09-12protein level
7 37 4
2013-08-17protein level
7 37 4
2013-07-15protein level
7 17 4
2013-06-11protein level
7 17 4
2013-02-12protein level
5 7 9
2012-12-20protein level
5 9 9
2012-10-30protein level
5 17 9
2012-10-07protein level
5 17 2
2012-08-24protein level
5 13 2
2012-07-28protein level
5 13 2
2012-06-08protein level
5 13 2
2012-05-07protein level
5 13 2
2012-04-10protein level
4 13 2
2012-01-13protein level
4 7 2
2011-12-20protein level
4 7 2
2011-11-11protein level
4 7 2
2011-08-23protein level
4 7 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O60941-1
1 21 6 71309.415
NX_O60941-2
0 21 5 64560.9407
NX_O60941-3
1 19 5 64382.3403
NX_O60941-4
0 21 5 68016.6939
NX_O60941-5
0 21 5 63718.566
NX_O60941-6
0 18 6 61498.5883
NX_O60941-7
0 21 6 69249.5453
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740402,EBI-295827 DMD  
  .positive regulation of sodium ion transmembrane transporter activity
.negative regulation of peptidyl-cysteine S-nitrosylation
.regulation of voltage-gated calcium channel activity
  + 23 more...
.nitric-oxide synthase binding
.vinculin binding
.myosin binding
  + 5 more...
.postsynaptic membrane
.synapse
.membrane raft
  + 15 more...
2 EBI-740402,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
3 EBI-740402,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
4 EBI-740402,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
5 EBI-740402,EBI-745426 PPFIA1  
  .negative regulation of establishment of protein localization to plasma membrane
.negative regulation of stress fiber assembly
.glutamate secretion
  + 4 more...
.signal transducer activity .presynaptic active zone
.focal adhesion
.cytosol
.cytoplasm
6 EBI-740402,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
7 EBI-740402,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
8 EBI-740402,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
9 EBI-740402,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
10 EBI-740402,EBI-395708 ZBTB9  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
11 EBI-740402,EBI-465804 DTNBP1  
  .membrane organization
.regulation of dopamine receptor signaling pathway
.platelet dense granule organization
  + 11 more...
.N/A .postsynaptic membrane
.dendritic spine
.neuron projection
  + 14 more...
12 EBI-740402,EBI-741977 CEP63  
  .cell division
.spindle assembly
.signal transduction in response to DNA damage
  + 6 more...
.N/A .cytosol
.centriole
.centrosome
.spindle pole
13 EBI-740402,EBI-8483734 SPZ1  
  .transcription, DNA-templated .sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleus
14 EBI-740402,EBI-928842 NDEL1  
  .neuron projection extension
.neurofilament cytoskeleton organization
.centrosome localization
  + 20 more...
.oligopeptidase activity
.microtubule binding
.neurofilament cytoskeleton
.axon hillock
.cell leading edge
  + 10 more...
15 EBI-740402,EBI-740641 HMG20A  
  .negative regulation of neuron differentiation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
  + 3 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.nucleus
16 EBI-740402,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
17 EBI-740402,EBI-742038 ABI3  
  .regulation of cell migration
.movement of cell or subcellular component
.N/A .lamellipodium
.membrane
.cytoplasm
.intracellular
18 EBI-740402,EBI-447141 GGA1  
  .positive regulation of protein catabolic process
.vesicle-mediated transport
.intracellular protein transport
.N/A .intracellular membrane-bounded organelle
.clathrin adaptor complex
.membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood32
bone13
brain62
cervix144
connective tissue20
embryonic tissue28
eye19
intestine30
kidney23
larynx127
liver14
lung14
lymph45
lymph node22
mammary gland79
muscle9
nerve128
ovary49
pancreas9
parathyroid48
pharynx24
placenta28
prostate68
salivary gland49
skin18
spleen37
stomach41
testis41
thymus37
thyroid42
trachea57
uterus25
Health State
TissuesTPM*
normal41
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma12
colorectal tumor17
gastrointestinal tumor42
germ cell tumor37
glioma9
head and neck tumor44
kidney tumor14
liver tumor31
lung tumor9
lymphoma27
non-neoplasia51
pancreatic tumor19
primitive neuroectodermal tumor of the CNS94
prostate cancer19
retinoblastoma21
skin tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult33
embryoid body28
neonate32
fetus25
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.3
adrenal gland4.4
appendix9
bone marrow4.5
cerebral cortex17.2
colon4.1
duodenum3.7
esophagus6
gallbladder8.7
heart muscle4.7
kidney7.4
liver2.6
lung8
lymph node9
ovary9.1
pancreas6.8
placenta9.2
prostate12.6
salivary gland44.6
skin7.3
small intestine3
spleen7.3
stomach9.9
testis12.9
thyroid gland20.6
urinary bladder8.7
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
breastHigh
bronchusHigh
cerebellumMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2High
epididymisHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
kidneyHigh
liverHigh
lungLow
nasopharynxHigh
pancreasHigh
parathyroid glandLow
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleLow
small intestineHigh
smooth muscleLow
stomach 1Medium
stomach 2High
testisLow
thyroid glandMedium
tonsilMedium
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602415, gene) Dystrobrevin, beta; DTNBOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center