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> Protein (NX_O75044)
Protein (NX_O75044)
Protein
Gene SymbolSRGAP2 to neXtProt (NX_O75044)
DescriptionSLIT-ROBO Rho GTPase-activating protein 2
Chromosome1
Location1q32.1 (206516200 ~ 206637783) to Ensembl
Sequene Features : Isoforms 1, Variants 1, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of neuron migration
.dendritic spine development
.regulation of small GTPase mediated signal transduction
  + 9 more...
.Rac GTPase binding
.protein homodimerization activity
.GTPase activator activity
.phagocytic vesicle
.postsynaptic membrane
.dendritic spine head
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 1 7
2014-09-19protein level
1 1 7
2014-05-27protein level
1 1 9
2014-02-25protein level
1 1 9
2013-12-09protein level
1 1 9
2013-11-01protein level
1 1 9
2013-09-12protein level
1 1 10
2013-08-17protein level
1 1 10
2013-07-15protein level
1 1 9
2013-06-11protein level
1 1 9
2013-02-12protein level
1 1 11
2012-12-20protein level
1 1 11
2012-10-30protein level
1 1 11
2012-10-07protein level
1 1 11
2012-08-24protein level
1 1 11
2012-07-28protein level
1 1 10
2012-06-08protein level
1 1 10
2012-05-07protein level
1 1 10
2012-04-10protein level
1 1 10
2012-01-13protein level
1 1 10
2011-12-20protein level
1 1 10
2011-11-11protein level
1 1 10
2011-08-23protein level
1 1 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75044-1
25 0 21 120804.2877
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1051034,EBI-351098 PRMT5  
  .histone H4-R3 methylation
.endothelial cell activation
.peptidyl-arginine N-methylation
  + 12 more...
.protein heterodimerization activity
.ribonucleoprotein complex binding
.protein-arginine omega-N symmetric methyltransferase activity
  + 5 more...
.methylosome
.cytosol
.cytoplasm
  + 2 more...
2 EBI-1051034,EBI-720020 FMNL1  
  .actin filament severing
.cortical actin cytoskeleton organization
.regulation of cell shape
  + 2 more...
.actin filament binding
.Rac GTPase binding
.GTPase activating protein binding
.extracellular exosome
.phagocytic vesicle
.bleb
  + 4 more...
3 EBI-1051034,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
4 EBI-1051034,EBI-495538 FASLG  
  .positive regulation of endothelial cell apoptotic process
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 30 more...
.receptor binding .extracellular exosome
.cytoplasmic membrane-bounded vesicle lumen
.perinuclear region of cytoplasm
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites25
blood16
bone69
bone marrow20
brain91
cervix82
connective tissue53
ear62
embryonic tissue70
eye71
heart33
intestine17
kidney23
larynx42
liver9
lung41
lymph node144
mammary gland19
mouth15
muscle18
pancreas4
placenta3
skin4
testis4
Health State
TissuesTPM*
normal9
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor10
gastrointestinal tumor16
head and neck tumor7
kidney tumor14
Developmental Stage
TissuesTPM*
adult2
embryoid body128
blastocyst16
neonate32
fetus8
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue34.2
adrenal gland30.1
appendix29.2
bone marrow24
cerebral cortex37
colon11.7
duodenum10.1
esophagus19.6
gallbladder25.9
heart muscle12.8
kidney19.9
liver8.9
lung35.2
lymph node29.5
ovary31.8
pancreas5.3
placenta34.9
prostate12.3
salivary gland5.6
skin59.8
small intestine10.1
spleen47.3
stomach10.9
testis18.1
thyroid gland14.3
urinary bladder26.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606524, gene) Slit-robo rho gtpase-activating protein 2; SRGAP2OMIM


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