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> Protein (NX_O75150)
Protein (NX_O75150)
Protein
Gene SymbolRNF40 to neXtProt (NX_O75150)
DescriptionE3 ubiquitin-protein ligase BRE1B
Chromosome16
Location16p11.2 (30773066 ~ 30787628) to Ensembl
Sequene Features : Isoforms 3, Variants 116, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.histone H2B ubiquitination
  + 2 more...
.protein homodimerization activity
.ubiquitin protein ligase binding
.ligase activity
  + 3 more...
.neuron projection
.HULC complex
.membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 116 4
2014-09-19protein level
3 88 4
2014-05-27protein level
3 88 5
2014-02-25protein level
3 87 3
2013-12-09protein level
3 66 3
2013-11-01protein level
3 65 2
2013-09-12protein level
3 65 2
2013-08-17protein level
3 65 2
2013-07-15protein level
3 40 2
2013-06-11protein level
3 40 2
2013-02-12protein level
3 13 3
2012-12-20protein level
3 13 3
2012-10-30protein level
3 18 3
2012-10-07protein level
3 18 1
2012-08-24protein level
3 16 1
2012-07-28protein level
3 16 1
2012-06-08protein level
3 27 1
2012-05-07protein level
3 23 1
2012-04-10protein level
3 23 1
2012-01-13protein level
3 16 1
2011-12-20protein level
3 16 1
2011-11-11protein level
3 16 1
2011-08-23protein level
3 16 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75150-1
0 40 2 113580.2522
NX_O75150-3
1 30 2 94737.381
NX_O75150-4
1 35 2 101983.335
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744408,EBI-491274 RB1  
  .negative regulation of G1/S transition of mitotic cell cycle
.hepatocyte apoptotic process
.regulation of centromere complex assembly
  + 39 more...
.phosphoprotein binding
.androgen receptor binding
.identical protein binding
  + 7 more...
.Rb-E2F complex
.PML body
.SWI/SNF complex
  + 4 more...
2 EBI-744408,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
3 EBI-744408,EBI-2372238 RNF20  
  .positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.positive regulation of transcription, DNA-templated
  + 7 more...
.histone binding
.ubiquitin protein ligase binding
.ligase activity
  + 6 more...
.HULC complex
.nucleolus
.nucleoplasm
  + 2 more...
4 EBI-744408,EBI-1104535 SFR1  
  .double-strand break repair via homologous recombination .N/A .Swi5-Sfr1 complex
.nucleus
5 EBI-744408,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
6 EBI-744408,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder66
blood122
bone69
bone marrow41
brain276
cervix123
connective tissue87
ear248
embryonic tissue131
esophagus148
eye114
heart44
intestine125
kidney71
liver43
lung119
lymph293
lymph node55
mammary gland165
mouth393
muscle188
nerve64
ovary78
pancreas103
pituitary gland60
placenta123
prostate84
salivary gland197
skin132
spleen187
stomach31
testis546
thymus338
thyroid85
trachea598
umbilical cord3342
uterus224
vascular19
Health State
TissuesTPM*
normal164
breast (mammary gland) tumor225
cervical tumor57
chondrosarcoma96
colorectal tumor97
esophageal tumor173
gastrointestinal tumor67
germ cell tumor277
glioma139
head and neck tumor216
kidney tumor101
leukemia127
liver tumor72
lung tumor155
lymphoma249
non-neoplasia82
ovarian tumor65
pancreatic tumor199
primitive neuroectodermal tumor of the CNS94
prostate cancer105
retinoblastoma193
skin tumor199
soft tissue/muscle tissue tumor199
uterine tumor122
Developmental Stage
TissuesTPM*
adult111
embryoid body157
blastocyst162
neonate1287
fetus197
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.2
adrenal gland37.6
appendix33.8
bone marrow56
cerebral cortex35.4
colon33.4
duodenum27.7
esophagus31.3
gallbladder34
heart muscle18.2
kidney32.2
liver22
lung37.4
lymph node33.5
ovary47.3
pancreas19.6
placenta32.2
prostate33.6
salivary gland31.6
skin35.9
small intestine30
spleen32.6
stomach30.7
testis67.5
thyroid gland38.7
urinary bladder35.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607700, gene) Ring finger protein 40; RNF40OMIM


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