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> Protein (NX_O75175)
Protein (NX_O75175)
Protein
Gene SymbolCNOT3 to neXtProt (NX_O75175)
DescriptionCCR4-NOT transcription complex subunit 3
Chromosome19
Location19q13.42 (54641444 ~ 54659419) to Ensembl
Sequene Features : Isoforms 3, Variants 91, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of stem cell maintenance
.gene silencing by RNA
.gene expression
  + 6 more...
.N/A .CCR4-NOT complex
.cytosol
.nucleus
.cytoplasmic mRNA processing body
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 91 6
2014-09-19protein level
3 67 6
2014-05-27protein level
3 67 6
2014-02-25protein level
3 65 6
2013-12-09protein level
3 57 6
2013-11-01protein level
3 54 4
2013-09-12protein level
3 54 4
2013-08-17protein level
3 54 4
2013-07-15protein level
3 32 4
2013-06-11protein level
3 32 4
2013-02-12protein level
3 21 6
2012-12-20protein level
3 20 6
2012-10-30protein level
3 22 6
2012-10-07protein level
3 22 2
2012-08-24protein level
3 22 2
2012-07-28protein level
3 22 2
2012-06-08protein level
3 0 2
2012-05-07protein level
3 0 2
2012-04-10protein level
3 0 2
2012-01-13protein level
3 0 2
2011-12-20protein level
3 0 2
2011-11-11protein level
3 0 2
2011-08-23protein level
3 0 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75175-1
3 19 0 81821.4235
NX_O75175-2
1 16 0 64013.9401
NX_O75175-3
4 13 0 58804.5648
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-743073,EBI-723281 TOB1  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 6 more...
.receptor tyrosine kinase binding
.SH3/SH2 adaptor activity
.transcription corepressor activity
.CCR4-NOT complex
.cytoplasm
.nucleus
2 EBI-743073,EBI-1046635 CNOT6L  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.mRNA destabilization
.gene silencing by RNA
  + 8 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.CCR4-NOT complex
.cytosol
.cytoplasm
.nucleus
3 EBI-743073,EBI-743033 CNOT2  
  .regulation of stem cell maintenance
.RNA phosphodiester bond hydrolysis, exonucleolytic
.negative regulation of intracellular estrogen receptor signaling pathway
  + 10 more...
.RNA polymerase II transcription corepressor binding
.RNA polymerase II transcription cofactor activity
.CCR4-NOT complex
.membrane
.cytosol
  + 2 more...
4 EBI-743073,EBI-742299 CNOT8  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of mRNA catabolic process
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
  + 9 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.RNA binding
  + 2 more...
.CCR4-NOT complex
.cytosol
.nucleus
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder100
blood16
bone27
brain53
connective tissue20
embryonic tissue98
eye57
heart44
intestine81
kidney37
larynx255
liver34
lung44
lymph67
lymph node33
mammary gland33
mouth75
nerve64
ovary157
pancreas42
pituitary gland121
placenta17
prostate52
salivary gland49
skin104
spleen18
stomach83
testis41
thymus112
thyroid85
trachea19
uterus77
vascular19
Health State
TissuesTPM*
normal42
bladder carcinoma170
breast (mammary gland) tumor32
chondrosarcoma36
colorectal tumor79
gastrointestinal tumor92
germ cell tumor79
glioma130
head and neck tumor104
kidney tumor43
leukemia10
liver tumor41
lung tumor58
lymphoma69
non-neoplasia20
ovarian tumor91
pancreatic tumor38
primitive neuroectodermal tumor of the CNS47
prostate cancer57
retinoblastoma43
skin tumor167
soft tissue/muscle tissue tumor55
uterine tumor99
Developmental Stage
TissuesTPM*
adult53
embryoid body100
blastocyst179
neonate64
fetus62
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.8
adrenal gland17.9
appendix20.6
bone marrow15.2
cerebral cortex11.7
colon12.8
duodenum16.8
esophagus14.3
gallbladder14.7
heart muscle9.9
kidney12.8
liver6.3
lung16.5
lymph node22.5
ovary19.7
pancreas8.6
placenta19.1
prostate21
salivary gland16.3
skin23.9
small intestine17
spleen26.1
stomach18.1
testis29.8
thyroid gland19.3
urinary bladder15.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandLow
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604910, gene) Ccr4-not transcription complex, subunit 3; CNOT3OMIM


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