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> Protein (NX_O75190)
Protein (NX_O75190)
Protein
Gene SymbolDNAJB6 to neXtProt (NX_O75190)
DescriptionDnaJ homolog subfamily B member 6
Chromosome7
Location7q36.3 (157128075 ~ 157210133) to Ensembl
Sequene Features : Isoforms 4, Variants 41, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cellular response to heat
.negative regulation of inclusion body assembly
.chorion development
  + 11 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
  + 2 more...
.perinuclear region of cytoplasm
.Z disc
.membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 41 5
2014-09-19protein level
4 28 5
2014-05-27protein level
4 27 6
2014-02-25protein level
3 25 6
2013-12-09protein level
3 21 6
2013-11-01protein level
3 18 4
2013-09-12protein level
3 18 4
2013-08-17protein level
3 18 4
2013-07-15protein level
3 7 2
2013-06-11protein level
3 7 2
2013-02-12protein level
3 5 2
2012-12-20protein level
3 5 2
2012-10-30protein level
3 6 2
2012-10-07protein level
3 6 1
2012-08-24protein level
3 6 1
2012-07-28protein level
3 6 1
2012-06-08protein level
3 4 1
2012-05-07protein level
3 4 1
2012-04-10protein level
3 4 1
2012-01-13protein level
3 2 1
2011-12-20protein level
3 2 1
2011-11-11protein level
3 2 1
2011-08-23protein level
3 2 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75190-1
0 9 3 36064.7702
NX_O75190-2
0 5 3 26883.0548
NX_O75190-3
2 8 3 35692.3778
NX_O75190-4
0 7 2 30349.9691
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1053164,EBI-2799016 DYSF  
  .vesicle fusion
.plasma membrane repair
.calcium-dependent phospholipid binding
.phospholipid binding
.calcium ion binding
.extracellular exosome
.sarcolemma
.cytoplasmic vesicle membrane
  + 8 more...
2 EBI-1053164,EBI-297888 KRT18  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.intermediate filament cytoskeleton organization
  + 6 more...
.scaffold protein binding
.poly(A) RNA binding
.structural molecule activity
.cell periphery
.extracellular exosome
.perinuclear region of cytoplasm
  + 6 more...
3 EBI-1053164,EBI-721328 MLF1  
  .cell cycle arrest
.transcription, DNA-templated
.myeloid progenitor cell differentiation
.protein domain specific binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
4 EBI-1053164,EBI-5357343 SGCG  
  .membrane organization
.heart contraction
.muscle cell development
  + 2 more...
.N/A .sarcolemma
.integral component of membrane
.sarcoglycan complex
  + 3 more...
5 EBI-1053164,EBI-1051875 MLF2  
  .defense response .N/A .membrane
.cytoplasm
.nucleus
6 EBI-1053164,EBI-714781 BRMS1  
  .positive regulation of anoikis
.positive regulation of protein deacetylation
.negative regulation of transcription, DNA-templated
  + 6 more...
.NF-kappaB binding
.histone deacetylase binding
.Sin3-type complex
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites301
bladder133
blood16
bone13
bone marrow143
brain30
cervix20
connective tissue6
ear124
embryonic tissue23
esophagus297
eye28
heart11
intestine12
kidney33
larynx42
liver19
lung14
lymph22
lymph node33
mammary gland26
mouth30
muscle28
nerve64
ovary19
pancreas18
parathyroid194
pharynx294
pituitary gland242
placenta49
prostate10
salivary gland197
skin4
spleen299
stomach10
testis59
thymus12
thyroid42
trachea38
uterus34
vascular677
Health State
TissuesTPM*
normal35
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma12
colorectal tumor124
esophageal tumor347
gastrointestinal tumor210
germ cell tumor53
glioma130
head and neck tumor37
kidney tumor29
leukemia42
liver tumor31
lung tumor9
lymphoma55
non-neoplasia144
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS31
prostate cancer86
retinoblastoma43
skin tumor215
soft tissue/muscle tissue tumor15
uterine tumor44
Developmental Stage
TissuesTPM*
adult26
embryoid body14
blastocyst32
neonate32
fetus25
infant255
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue39.4
adrenal gland40.9
appendix34.3
bone marrow73.1
cerebral cortex47.3
colon34
duodenum23.9
esophagus51
gallbladder32.1
heart muscle58.9
kidney39.1
liver18.1
lung36.5
lymph node30.5
ovary34.6
pancreas12.5
placenta41.7
prostate35.5
salivary gland27
skin44.9
small intestine27.5
spleen33.8
stomach23.6
testis64.9
thyroid gland26.1
urinary bladder43.1
Tissues
TissuesExpression level
adrenal glandLow
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
epididymisMedium
fallopian tubeHigh
hippocampusMedium
lateral ventricleMedium
liverLow
lungMedium
nasopharynxHigh
parathyroid glandLow
skin 1Medium
testisMedium
thyroid glandLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#603511, phenotype) Muscular dystrophy, limb-girdle, type 1e; LGMD1EOMIM
2(*611332, gene) Dnaj/hsp40 homolog, subfamily b, member 6; DNAJB6OMIM


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