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> Protein (NX_O75293)
Protein (NX_O75293)
Protein
Gene SymbolGADD45B to neXtProt (NX_O75293)
DescriptionGrowth arrest and DNA damage-inducible protein GADD45 beta
Chromosome19
Location19p13.3 (2476120 ~ 2478257) to Ensembl
Sequene Features : Isoforms 1, Variants 11, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of p38MAPK cascade
.regulation of cell cycle
.positive regulation of JNK cascade
  + 8 more...
.N/A .cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 11 0
2014-09-19protein level
1 6 0
2014-05-27protein level
1 6 0
2014-02-25protein level
1 6 0
2013-12-09protein level
1 4 0
2013-11-01protein level
1 4 0
2013-09-12protein level
1 4 0
2013-08-17protein level
1 4 0
2013-07-15protein level
1 4 0
2013-06-11protein level
1 4 0
2013-02-12protein level
1 1 0
2012-12-20protein level
1 1 0
2012-10-30protein level
1 2 0
2012-10-07protein level
1 2 0
2012-08-24protein level
1 2 0
2012-07-28protein level
1 2 0
2012-06-08protein level
1 5 0
2012-05-07protein level
1 4 0
2012-04-10protein level
1 4 0
2012-01-13protein level
1 3 0
2011-12-20protein level
1 3 0
2011-11-11protein level
1 3 0
2011-08-23protein level
1 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75293-1
8 0 0 17806.6556
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-448187,EBI-492605 MAP2K7  
  .cellular response to sorbitol
.stress-activated MAPK cascade
.innate immune response
  + 22 more...
.protein phosphatase binding
.protein kinase binding
.enzyme binding
  + 6 more...
.cytosol
.cytoplasm
.nucleus
.intracellular
2 EBI-448187,EBI-448104 MAP3K4  
  .positive regulation of p38MAPK cascade
.chorionic trophoblast cell differentiation
.positive regulation of JUN kinase activity
  + 8 more...
.metal ion binding
.ATP binding
.MAP kinase kinase kinase activity
.MAP kinase kinase activity
.perinuclear region of cytoplasm
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
adrenal gland91
ascites5447
blood65
bone167
bone marrow102
brain64
connective tissue87
embryonic tissue46
esophagus49
eye105
heart78
intestine90
kidney94
liver102
lung215
lymph22
lymph node155
mammary gland59
muscle47
nerve64
ovary197
pancreas89
parathyroid145
pharynx24
pituitary gland121
placenta67
prostate31
skin61
spleen131
testis6
thymus37
thyroid42
trachea19
uterus21
vascular96
Health State
TissuesTPM*
normal93
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma169
colorectal tumor44
esophageal tumor57
gastrointestinal tumor1839
glioma121
head and neck tumor14
kidney tumor29
leukemia63
liver tumor62
lung tumor68
lymphoma13
non-neoplasia72
ovarian tumor236
pancreatic tumor47
prostate cancer38
skin tumor63
soft tissue/muscle tissue tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult87
embryoid body114
blastocyst16
neonate32
fetus66
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue94.1
adrenal gland69.9
appendix39.8
bone marrow182.5
cerebral cortex24.5
colon24.1
duodenum17.3
esophagus31.6
gallbladder107.2
heart muscle35.8
kidney57.3
liver201.5
lung60.9
lymph node34.7
ovary24.7
pancreas46.8
placenta41.1
prostate69.5
salivary gland49.6
skin9.2
small intestine19.2
spleen28.7
stomach24.1
testis10.1
thyroid gland55.3
urinary bladder42.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604948, gene) Growth arrest- and dna damage-inducible gene gadd45, beta; GADD45BOMIM


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