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> Protein (NX_O75298)
Protein (NX_O75298)
Protein
Gene SymbolRTN2 to neXtProt (NX_O75298)
DescriptionReticulon-2
Chromosome19
Location19q13.32 (45988547 ~ 46000319) to Ensembl
Sequene Features : Isoforms 3, Variants 69, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intracellular protein transmembrane transport
.regulation of glucose import
.N/A .T-tubule
.integral component of endoplasmic reticulum membrane
.terminal cisterna
.endoplasmic reticulum
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 69 1
2014-09-19protein level
3 49 1
2014-05-27protein level
3 49 1
2014-02-25protein level
3 49 1
2013-12-09protein level
3 37 1
2013-11-01protein level
3 37 1
2013-09-12protein level
3 37 1
2013-08-17protein level
3 37 1
2013-07-15protein level
3 21 1
2013-06-11protein level
3 21 1
2013-02-12protein level
3 11 2
2012-12-20protein level
3 11 2
2012-10-30protein level
3 13 2
2012-10-07protein level
3 13 1
2012-08-24protein level
3 8 1
2012-07-28protein level
3 8 1
2012-06-08protein level
3 8 1
2012-05-07transcript level
3 7 1
2012-04-10transcript level
3 7 1
2012-01-13transcript level
3 6 1
2011-12-20transcript level
3 6 1
2011-11-11transcript level
3 6 1
2011-08-23transcript level
3 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75298-1
5 21 0 59227.3579
NX_O75298-2
1 20 0 51397.0514
NX_O75298-3
0 9 0 22302.2241
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
blood16
bone27
brain30
embryonic tissue14
eye62
heart22
intestine4
kidney18
larynx85
lung29
lymph22
mammary gland79
muscle235
nerve128
pancreas14
parathyroid97
placenta42
prostate15
salivary gland49
skin42
uterus12
Health State
TissuesTPM*
normal33
breast (mammary gland) tumor21
chondrosarcoma24
colorectal tumor8
germ cell tumor15
glioma9
head and neck tumor22
kidney tumor29
leukemia10
lymphoma13
non-neoplasia20
pancreatic tumor28
primitive neuroectodermal tumor of the CNS70
retinoblastoma86
skin tumor7
soft tissue/muscle tissue tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult34
embryoid body14
blastocyst16
fetus28
infant255
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.6
adrenal gland7
appendix4.8
bone marrow2
cerebral cortex21.1
colon5.1
duodenum2
esophagus12.1
gallbladder8.6
heart muscle11.5
kidney3.5
liver2.5
lung7.2
lymph node5.8
pancreas4.1
placenta22.3
prostate16.7
salivary gland12.1
skin5.6
small intestine4
spleen7
stomach5.4
testis2.3
thyroid gland4
urinary bladder9.5
Tissues
TissuesExpression level
adrenal glandMedium
breastHigh
cerebellumLow
cerebral cortexLow
lungLow
skeletal muscleMedium
skin 2Low
smooth muscleMedium
stomach 2Low
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603183, gene) Reticulon 2; RTN2OMIM
2(#604805, phenotype) Spastic paraplegia 12, autosomal dominant; SPG12OMIM


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