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> Protein (NX_O75326)
Protein (NX_O75326)
Protein
Gene SymbolSEMA7A to neXtProt (NX_O75326)
DescriptionSemaphorin-7A
Chromosome15
Location15q24.1 (74701630 ~ 74726808) to Ensembl
Sequene Features : Isoforms 2, Variants 80, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of ERK1 and ERK2 cascade
.positive regulation of macrophage cytokine production
.regulation of inflammatory response
  + 9 more...
.receptor activity .anchored component of membrane
.membrane
.external side of plasma membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 80 15
2014-09-19protein level
2 59 15
2014-05-27protein level
2 59 15
2014-02-25protein level
2 59 15
2013-12-09protein level
2 44 15
2013-11-01protein level
2 41 15
2013-09-12protein level
2 41 15
2013-08-17protein level
2 41 15
2013-07-15protein level
2 32 15
2013-06-11protein level
2 32 15
2013-02-12protein level
2 15 29
2012-12-20protein level
1 15 15
2012-10-30protein level
1 17 15
2012-10-07protein level
1 16 15
2012-08-24protein level
1 13 15
2012-07-28protein level
1 13 15
2012-06-08protein level
1 15 15
2012-05-07protein level
1 15 15
2012-04-10protein level
1 15 15
2012-01-13protein level
1 14 15
2011-12-20protein level
1 14 15
2011-11-11protein level
1 14 15
2011-08-23protein level
1 14 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75326-1
2 29 0 74775.9636
NX_O75326-2
1 29 0 73317.2067
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1753538,EBI-2927384 PLXNC1  
  .axon guidance
.signal transduction
.cell adhesion
.receptor binding
.receptor activity
.integral component of membrane
.membrane
.plasma membrane
.intracellular
2 EBI-1753538,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
blood24
bone13
bone marrow20
brain118
connective tissue13
embryonic tissue9
eye19
intestine4
kidney23
lung5
lymph node55
mammary gland6
ovary9
pancreas14
placenta127
prostate5
skin9
spleen56
testis34
thymus50
trachea19
uterus4
vascular19
Health State
TissuesTPM*
normal57
adrenal tumor158
breast (mammary gland) tumor10
germ cell tumor11
glioma18
lung tumor9
non-neoplasia31
ovarian tumor13
pancreatic tumor9
Developmental Stage
TissuesTPM*
adult56
embryoid body28
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.2
adrenal gland1.4
appendix15.9
bone marrow11.7
cerebral cortex13.5
colon2.5
duodenum2.7
esophagus4.4
gallbladder4
heart muscle1.1
kidney1.5
liver2
lung5
lymph node26.9
ovary6.9
placenta44.5
prostate1.3
salivary gland1.5
skin4.5
small intestine3.2
spleen45.3
stomach5.8
testis39.6
urinary bladder8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607961, gene) Semaphorin 7a; SEMA7AOMIM
2(#614745, phenotype) Blood group, john milton hagen systemOMIM


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