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> Protein (NX_O75344)
Protein (NX_O75344)
Protein
Gene SymbolFKBP6 to neXtProt (NX_O75344)
DescriptionInactive peptidyl-prolyl cis-trans isomerase FKBP6
Chromosome7
Location7q11.23 (72742167 ~ 72772634) to Ensembl
Sequene Features : Isoforms 3, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.chaperone-mediated protein folding
.DNA methylation involved in gamete generation
.piRNA metabolic process
  + 6 more...
.Hsp90 protein binding
.FK506 binding
.peptidyl-prolyl cis-trans isomerase activity
.cytosol
.endoplasmic reticulum membrane
.cytoplasm
.synaptonemal complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 54 0
2014-09-19protein level
3 39 0
2014-05-27protein level
3 39 0
2014-02-25protein level
2 39 0
2013-12-09protein level
2 27 0
2013-11-01protein level
2 27 0
2013-09-12protein level
2 27 0
2013-08-17protein level
2 27 0
2013-07-15protein level
2 17 0
2013-06-11protein level
2 17 0
2013-02-12protein level
2 6 0
2012-12-20protein level
2 4 0
2012-10-30protein level
2 4 0
2012-10-07protein level
2 4 0
2012-08-24protein level
2 4 0
2012-07-28protein level
2 4 0
2012-06-08protein level
2 4 0
2012-05-07protein level
2 4 0
2012-04-10protein level
2 4 0
2012-01-13protein level
2 5 0
2011-12-20protein level
2 5 0
2011-11-11protein level
2 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75344-1
0 14 0 37189.8679
NX_O75344-2
1 13 0 36850.6759
NX_O75344-3
1 11 0 33531.0604
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744771,EBI-2681902 OSBP  
  .positive regulation of growth of symbiont in host
.lipid transport
.protein domain specific binding
.oxysterol binding
.cell junction
.membrane
.Golgi apparatus
  + 5 more...
2 EBI-744771,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
3 EBI-744771,EBI-718818 CDK5RAP3  
  .negative regulation of cellular protein catabolic process
.positive regulation of signal transduction by p53 class mediator
.positive regulation of protein localization to nucleus
  + 13 more...
.MDM2/MDM4 family protein binding
.NF-kappaB binding
.ubiquitin-like protein ligase binding
  + 2 more...
.protein complex
.membrane
.endomembrane system
  + 3 more...
4 EBI-744771,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain7
lung5
ovary9
testis105
Health State
TissuesTPM*
normal9
germ cell tumor18
leukemia10
ovarian tumor13
Developmental Stage
TissuesTPM*
adult2
fetus12
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.1
bone marrow1.3
duodenum2.1
gallbladder1.3
lung1.2
lymph node2.3
prostate2.2
salivary gland1.7
skin3
spleen1.3
stomach1.2
testis56
thyroid gland1.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604839, gene) Fk506-binding protein 6; FKBP6OMIM


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