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> Protein (NX_O75351)
Protein (NX_O75351)
Protein
Gene SymbolVPS4B to neXtProt (NX_O75351)
DescriptionVacuolar protein sorting-associated protein 4B
Chromosome18
Location18q21.33 (61056423 ~ 61089716) to Ensembl
Sequene Features : Isoforms 1, Variants 41, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of viral life cycle
.positive regulation of centriole elongation
.positive regulation of exosomal secretion
  + 27 more...
.protein homodimerization activity
.identical protein binding
.ATPase activity, coupled
  + 3 more...
.Flemming body
.extracellular exosome
.late endosome membrane
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 41 4
2014-09-19protein level
1 34 4
2014-05-27protein level
1 34 9
2014-02-25protein level
1 34 9
2013-12-09protein level
1 31 9
2013-11-01protein level
1 30 6
2013-09-12protein level
1 30 6
2013-08-17protein level
1 30 6
2013-07-15protein level
1 20 6
2013-06-11protein level
1 20 6
2013-02-12protein level
1 10 6
2012-12-20protein level
1 10 6
2012-10-30protein level
1 11 6
2012-10-07protein level
1 11 6
2012-08-24protein level
1 8 6
2012-07-28protein level
1 8 6
2012-06-08protein level
1 19 6
2012-05-07protein level
1 18 6
2012-04-10protein level
1 18 6
2012-01-13protein level
1 17 6
2011-12-20protein level
1 17 6
2011-11-11protein level
1 17 4
2011-08-23protein level
1 17 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75351-1
18 0 4 49271.3473
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2514459,EBI-6448240 ZFYVE19  
  .cell division
.negative regulation of cytokinesis
.abscission
.cell cycle
.phosphatidylinositol-3-phosphate binding
.zinc ion binding
.cleavage furrow
.midbody
.centrosome
.cytoplasm
2 EBI-2514459,EBI-751303 CHMP5  
  .regulation of mitotic spindle assembly
.multivesicular body sorting pathway
.membrane organization
  + 12 more...
.N/A .extracellular exosome
.endosome membrane
.cytosol
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites50
bladder33
blood49
bone27
bone marrow20
brain47
cervix20
connective tissue46
ear62
embryonic tissue37
esophagus99
eye43
heart44
intestine47
kidney47
liver38
lung38
lymph22
lymph node33
mammary gland33
mouth60
muscle37
nerve64
ovary19
pancreas32
parathyroid48
pharynx122
pituitary gland60
placenta52
prostate52
salivary gland49
skin28
spleen18
stomach10
testis68
thymus12
thyroid21
trachea38
uterus38
vascular58
Health State
TissuesTPM*
normal46
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma48
colorectal tumor35
esophageal tumor115
gastrointestinal tumor25
germ cell tumor22
glioma37
head and neck tumor22
kidney tumor14
leukemia10
liver tumor10
lung tumor9
lymphoma13
non-neoplasia72
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS31
prostate cancer86
retinoblastoma64
skin tumor39
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult41
blastocyst65
neonate32
fetus41
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.2
adrenal gland19.8
appendix28.4
bone marrow31.5
cerebral cortex19.8
colon41.7
duodenum33.8
esophagus69.9
gallbladder26.7
heart muscle13.8
kidney22.9
liver15
lung24.6
lymph node31.7
ovary19.4
pancreas9.3
placenta28.3
prostate23.6
salivary gland15.5
skin28.8
small intestine34.1
spleen25.5
stomach31.7
testis19.3
thyroid gland30.1
urinary bladder37.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609983, gene) Vacuolar protein sorting 4, s. cerevisiae, homolog of, b; VPS4BOMIM


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