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> Protein (NX_O75367)
Protein (NX_O75367)
Protein
Gene SymbolH2AFY to neXtProt (NX_O75367)
DescriptionCore histone macro-H2A.1
Chromosome5
Location5q31.1 (134669590 ~ 134735604) to Ensembl
Sequene Features : Isoforms 3, Variants 35, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cell cycle G2/M phase transition
.negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
.negative regulation of protein serine/threonine kinase activity
  + 13 more...
.transcription regulatory region DNA binding
.nucleosomal DNA binding
.chromatin DNA binding
  + 8 more...
.extracellular exosome
.nucleolus
.pericentric heterochromatin
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 35 18
2014-09-19protein level
3 24 18
2014-05-27protein level
3 24 18
2014-02-25protein level
3 24 16
2013-12-09protein level
3 23 16
2013-11-01protein level
3 23 13
2013-09-12protein level
3 23 13
2013-08-17protein level
3 23 13
2013-07-15protein level
3 15 8
2013-06-11protein level
3 15 8
2013-02-12protein level
3 7 27
2012-12-20protein level
3 7 27
2012-10-30protein level
3 8 27
2012-10-07protein level
3 8 9
2012-08-24protein level
3 6 9
2012-07-28protein level
3 6 9
2012-06-08protein level
3 10 9
2012-05-07protein level
3 10 9
2012-04-10protein level
3 10 9
2012-01-13protein level
3 8 9
2011-12-20protein level
3 8 9
2011-11-11protein level
3 8 11
2011-08-23protein level
3 8 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75367-1
0 14 2 39592.3504
NX_O75367-2
1 12 2 39159.0618
NX_O75367-3
0 14 2 39464.2559
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2868511,EBI-2682520 ERICH2  
  .N/A .N/A .N/A
2 EBI-2868511,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland151
ascites125
bladder33
blood8
bone139
bone marrow61
brain1
cervix206
connective tissue67
ear62
embryonic tissue216
esophagus49
eye9
heart55
intestine8
kidney56
larynx85
liver77
lung2
lymph158
lymph node178
mammary gland158
mouth90
muscle84
nerve193
ovary118
pancreas126
parathyroid48
pituitary gland363
placenta158
prostate5
salivary gland49
skin151
spleen112
stomach125
testis11
thymus138
thyroid42
tonsil117
trachea19
umbilical cord145
uterus4
vascular58
Health State
TissuesTPM*
normal2
adrenal tumor237
bladder carcinoma56
breast (mammary gland) tumor182
cervical tumor173
chondrosarcoma144
colorectal tumor97
gastrointestinal tumor160
germ cell tumor129
glioma93
head and neck tumor67
kidney tumor145
leukemia42
liver tumor83
lung tumor214
lymphoma180
non-neoplasia72
ovarian tumor144
pancreatic tumor171
primitive neuroectodermal tumor of the CNS244
prostate cancer9
retinoblastoma258
skin tumor247
soft tissue/muscle tissue tumor55
uterine tumor11
Developmental Stage
TissuesTPM*
adult130
embryoid body271
blastocyst162
neonate160
fetus87
infant255
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue61
adrenal gland61.8
appendix110.1
bone marrow252.7
cerebral cortex56
colon124.7
duodenum112.2
esophagus138.9
gallbladder95.1
heart muscle70.8
kidney48.8
liver31
lung78.8
lymph node135.1
ovary43.3
pancreas21.7
placenta83.7
prostate69.3
salivary gland45.2
skin105.5
small intestine118.5
spleen97.7
stomach89.6
testis39.9
thyroid gland64.7
urinary bladder102.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610054, gene) H2a histone family, member y; H2AFYOMIM


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