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> Protein (NX_O75369)
Protein (NX_O75369)
Protein
Gene SymbolFLNB to neXtProt (NX_O75369)
DescriptionFilamin-B
Chromosome3
Location3p14.3 (57994127 ~ 58157982) to Ensembl
Sequene Features : Isoforms 9, Variants 404, PTMs 40 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell differentiation
.actin cytoskeleton organization
.cytokine-mediated signaling pathway
  + 3 more...
.poly(A) RNA binding
.identical protein binding
.actin binding
.extracellular exosome
.Z disc
.integral component of membrane
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
9 404 40
2014-09-19protein level
9 318 40
2014-05-27protein level
9 318 45
2014-02-25protein level
9 317 41
2013-12-09protein level
9 236 41
2013-11-01protein level
9 219 34
2013-09-12protein level
9 219 35
2013-08-17protein level
9 219 35
2013-07-15protein level
9 165 33
2013-06-11protein level
9 165 33
2013-02-12protein level
9 116 243
2012-12-20protein level
9 113 243
2012-10-30protein level
9 127 243
2012-10-07protein level
9 127 29
2012-08-24protein level
9 119 29
2012-07-28protein level
9 119 29
2012-06-08protein level
9 137 29
2012-05-07protein level
9 111 29
2012-04-10protein level
7 110 29
2012-01-13protein level
7 73 29
2011-12-20protein level
7 73 29
2011-11-11protein level
7 73 23
2011-08-23protein level
7 73 23
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75369-1
0 123 11 277989.2741
NX_O75369-2
0 123 11 275495.1221
NX_O75369-3
0 121 11 273736.9866
NX_O75369-4
0 100 9 230642.7208
NX_O75369-5
0 100 9 230144.5036
NX_O75369-6
0 121 11 271242.8346
NX_O75369-7
1 118 5 257389.5797
NX_O75369-8
2 122 11 281457.9232
NX_O75369-9
0 123 11 276764.6912
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-352089,EBI-746466 ISG15  
  .type I interferon signaling pathway
.defense response to virus
.positive regulation of erythrocyte differentiation
  + 13 more...
.protein tag .cytosol
.nucleoplasm
.extracellular region
2 EBI-352089,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
3 EBI-352089,EBI-350432 FLNA  
  .positive regulation of integrin-mediated signaling pathway
.positive regulation of substrate adhesion-dependent cell spreading
.mitotic spindle assembly
  + 24 more...
.actin filament binding
.Rac GTPase binding
.poly(A) RNA binding
  + 8 more...
.apical dendrite
.extracellular exosome
.perinuclear region of cytoplasm
  + 15 more...
4 EBI-352089,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
5 EBI-352089,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
6 EBI-352089,EBI-49776 MAP3K1  
  .cellular response to mechanical stimulus
.eyelid development in camera-type eye
.stress-activated MAPK cascade
  + 21 more...
.protein kinase binding
.JUN kinase kinase activity
.zinc ion binding
  + 3 more...
.cytosol
.cytoplasm
7 EBI-352089,EBI-448104 MAP3K4  
  .positive regulation of p38MAPK cascade
.chorionic trophoblast cell differentiation
.positive regulation of JUN kinase activity
  + 8 more...
.metal ion binding
.ATP binding
.MAP kinase kinase kinase activity
.MAP kinase kinase activity
.perinuclear region of cytoplasm
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites251
bladder100
blood65
bone83
bone marrow82
brain74
cervix433
connective tissue67
ear124
embryonic tissue140
eye86
heart245
intestine362
kidney113
larynx127
liver389
lung125
lymph180
lymph node111
mammary gland284
mouth211
muscle366
nerve128
ovary187
pancreas210
parathyroid339
pharynx196
placenta141
prostate258
skin113
spleen131
stomach177
testis64
thymus288
thyroid322
trachea77
umbilical cord2688
uterus133
vascular96
Health State
TissuesTPM*
normal138
bladder carcinoma284
breast (mammary gland) tumor236
cervical tumor347
chondrosarcoma84
colorectal tumor471
gastrointestinal tumor227
germ cell tumor110
glioma65
head and neck tumor239
kidney tumor130
leukemia137
liver tumor249
lung tumor68
lymphoma124
non-neoplasia93
ovarian tumor236
pancreatic tumor314
primitive neuroectodermal tumor of the CNS7
prostate cancer231
skin tumor55
soft tissue/muscle tissue tumor87
uterine tumor188
Developmental Stage
TissuesTPM*
adult213
embryoid body185
blastocyst211
neonate643
fetus149
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue30.5
adrenal gland27.3
appendix26.2
bone marrow5.7
cerebral cortex7.2
colon74.1
duodenum43.4
esophagus25.8
gallbladder21.4
heart muscle11.5
kidney35.6
liver35.6
lung31.1
lymph node21.8
ovary32.6
pancreas21.3
placenta38.8
prostate73.2
salivary gland32.5
skin60.6
small intestine47.5
spleen30.6
stomach46.8
testis21.6
thyroid gland41.5
urinary bladder30.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastHigh
bronchusHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
kidneyHigh
liverHigh
lungHigh
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2High
small intestineHigh
soft tissue 1Medium
soft tissue 2Low
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#108720, phenotype) Atelosteogenesis, type i; AOIOMIM
2(#108721, phenotype) Atelosteogenesis, type iii; AOIIIOMIM
3(#112310, phenotype) Boomerang dysplasiaOMIM
4(#150250, phenotype) Larsen syndrome; LRSOMIM
5(#272460, phenotype) Spondylocarpotarsal synostosis syndrome; SCTOMIM
6(*603381, gene) Filamin b; FLNBOMIM


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