Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_O75376)
Protein (NX_O75376)
Protein
Gene SymbolNCOR1 to neXtProt (NX_O75376)
DescriptionNuclear receptor corepressor 1
Chromosome17
Location17p11.2 (15932471 ~ 16121499) to Ensembl
Sequene Features : Isoforms 3, Variants 270, PTMs 27 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of fatty acid transport
.regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
.regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
  + 22 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.histone deacetylase binding
  + 6 more...
.transcriptional repressor complex
.membrane
.spindle microtubule
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 270 27
2014-09-19protein level
3 198 27
2014-05-27protein level
3 198 27
2014-02-25protein level
3 196 26
2013-12-09protein level
3 145 26
2013-11-01protein level
3 136 25
2013-09-12protein level
3 136 26
2013-08-17protein level
3 136 26
2013-07-15protein level
3 84 26
2013-06-11protein level
3 84 26
2013-02-12protein level
2 39 56
2012-12-20protein level
2 38 56
2012-10-30protein level
2 59 56
2012-10-07protein level
2 59 28
2012-08-24protein level
2 38 28
2012-07-28protein level
2 37 28
2012-06-08protein level
2 41 28
2012-05-07protein level
2 41 28
2012-04-10protein level
2 41 28
2012-01-13protein level
2 28 28
2011-12-20protein level
2 28 28
2011-11-11protein level
2 28 26
2011-08-23protein level
2 28 26
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75376-1
5 100 2 270043.6886
NX_O75376-2
0 101 2 258442.7153
NX_O75376-3
1 30 1 103854.9097
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347233,EBI-607682 HDAC3  
  .cellular response to fluid shear stress
.spindle assembly
.neurotrophin TRK receptor signaling pathway
  + 21 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.NF-kappaB binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 11 more...
.transcriptional repressor complex
.plasma membrane
.spindle microtubule
  + 5 more...
2 EBI-347233,EBI-413374 RARA  
  .cellular response to estrogen stimulus
.cellular response to retinoic acid
.cellular response to lipopolysaccharide
  + 54 more...
.alpha-actinin binding
.protein kinase A binding
.mRNA 5'-UTR binding
  + 19 more...
.perinuclear region of cytoplasm
.neuronal cell body
.dendrite
  + 6 more...
3 EBI-347233,EBI-347281 SKI  
  .protein homotrimerization
.SMAD protein signal transduction
.bone morphogenesis
  + 34 more...
.repressing transcription factor binding
.histone deacetylase inhibitor activity
.SMAD binding
  + 6 more...
.protein complex
.transcriptional repressor complex
.PML body
  + 6 more...
4 EBI-347233,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
5 EBI-347233,EBI-78615 PPARA  
  .negative regulation of transcription regulatory region DNA binding
.negative regulation of neuron death
.regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
  + 35 more...
.sequence-specific DNA binding
.ubiquitin conjugating enzyme binding
.lipid binding
  + 11 more...
.nucleoplasm
.nucleus
6 EBI-347233,EBI-78139 TRIM28  
  .regulation of genetic imprinting
.negative regulation of viral release from host cell
.negative regulation of DNA demethylation
  + 18 more...
.chromo shadow domain binding
.poly(A) RNA binding
.sequence-specific DNA binding
  + 10 more...
.RNA polymerase II transcription factor complex
.nuclear heterochromatin
.nuclear euchromatin
  + 2 more...
7 EBI-347233,EBI-1211456 DHX30  
  .RNA processing .poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
  + 2 more...
.mitochondrial nucleoid
.mitochondrion
.cytoplasm
.nucleus
8 EBI-347233,EBI-347111 DACH1  
  .negative regulation of DNA biosynthetic process
.negative regulation of cell proliferation involved in contact inhibition
.negative regulation of fibroblast proliferation
  + 7 more...
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly
.intracellular membrane-bounded organelle
.cytoplasm
.nucleolus
  + 3 more...
9 EBI-347233,EBI-7216962 NR2E3  
  .retina development in camera-type eye
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of rhodopsin gene expression
  + 10 more...
.sequence-specific DNA binding
.zinc ion binding
.ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
.steroid hormone receptor activity
.transcription factor complex
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland151
ascites75
bladder167
blood106
bone125
bone marrow82
brain81
cervix103
connective tissue40
embryonic tissue117
esophagus198
eye95
heart89
intestine176
kidney113
larynx170
liver87
lung101
lymph22
lymph node155
mammary gland79
mouth105
muscle65
ovary59
pancreas18
parathyroid48
pituitary gland60
placenta84
prostate116
salivary gland49
skin47
spleen18
stomach177
testis91
thymus100
thyroid150
trachea57
uterus129
vascular77
Health State
TissuesTPM*
normal86
adrenal tumor237
bladder carcinoma170
breast (mammary gland) tumor96
cervical tumor144
chondrosarcoma60
colorectal tumor195
esophageal tumor231
gastrointestinal tumor109
germ cell tumor91
glioma46
head and neck tumor104
kidney tumor116
leukemia137
liver tumor114
lung tumor29
lymphoma41
non-neoplasia186
ovarian tumor65
pancreatic tumor38
primitive neuroectodermal tumor of the CNS47
prostate cancer105
retinoblastoma86
skin tumor47
soft tissue/muscle tissue tumor111
uterine tumor210
Developmental Stage
TissuesTPM*
adult118
embryoid body157
blastocyst81
neonate64
fetus86
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.1
adrenal gland23
appendix32.2
bone marrow41.3
cerebral cortex29.1
colon46.6
duodenum49.9
esophagus32.1
gallbladder30.7
heart muscle22.1
kidney33.7
liver51.9
lung29.1
lymph node38.4
ovary36.2
pancreas18.7
placenta30.2
prostate31.4
salivary gland19.9
skin45.3
small intestine39.2
spleen33.7
stomach42.6
testis43.1
thyroid gland40.1
urinary bladder34.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
spleenLow
stomach 1Medium
stomach 2High
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600849, gene) Nuclear receptor corepressor 1; NCOR1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center