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> Protein (NX_O75379)
Protein (NX_O75379)
Protein
Gene SymbolVAMP4 to neXtProt (NX_O75379)
DescriptionVesicle-associated membrane protein 4
Chromosome1
Location1q24.3 (171669300 ~ 171711387) to Ensembl
Sequene Features : Isoforms 2, Variants 18, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.Golgi ribbon formation
.regulation of Golgi to plasma membrane protein transport
.SNARE complex assembly
  + 2 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.cell surface
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 18 2
2014-09-19protein level
2 14 2
2014-05-27protein level
2 14 2
2014-02-25protein level
2 14 2
2013-12-09protein level
2 10 2
2013-11-01protein level
2 10 2
2013-09-12protein level
2 10 2
2013-08-17protein level
2 10 2
2013-07-15protein level
2 7 2
2013-06-11protein level
2 7 2
2013-02-12protein level
2 4 4
2012-12-20protein level
2 3 4
2012-10-30protein level
2 4 4
2012-10-07protein level
2 4 2
2012-08-24protein level
2 4 2
2012-07-28protein level
2 4 2
2012-06-08protein level
2 5 2
2012-05-07protein level
2 5 2
2012-04-10protein level
2 5 2
2012-01-13protein level
2 3 2
2011-12-20protein level
2 3 2
2011-11-11protein level
2 3 2
2011-08-23protein level
2 3 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75379-1
1 4 0 16386.4819
NX_O75379-2
1 4 0 16230.3814
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10187996,EBI-490676 SNAP29  
  .membrane fusion
.synaptic vesicle fusion to presynaptic membrane
.synaptic vesicle priming
  + 4 more...
.syntaxin binding
.SNAP receptor activity
.synapse
.neuron projection
.SNARE complex
  + 4 more...
2 EBI-744953,EBI-744942 STX4  
  .positive regulation of protein localization to cell surface
.positive regulation of protein localization to plasma membrane
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 21 more...
.sphingomyelin phosphodiesterase activator activity
.SNAP receptor activity
.SNARE binding
.extracellular exosome
.perinuclear region of cytoplasm
.synapse
  + 19 more...
3 EBI-744953,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
4 EBI-10187996,EBI-747430 BCL2L13  
  .activation of cysteine-type endopeptidase activity involved in apoptotic process
.apoptotic process
.cysteine-type endopeptidase activator activity involved in apoptotic process .mitochondrial membrane
.integral component of membrane
.mitochondrion
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood16
bone13
bone marrow41
brain35
connective tissue26
embryonic tissue14
esophagus49
eye14
intestine21
kidney47
larynx42
liver34
lung29
lymph node33
mammary gland13
mouth45
muscle56
ovary9
parathyroid48
pituitary gland60
placenta10
prostate26
salivary gland49
skin47
spleen37
stomach41
testis45
thymus25
thyroid21
uterus21
vascular38
Health State
TissuesTPM*
normal37
bladder carcinoma56
breast (mammary gland) tumor10
chondrosarcoma60
colorectal tumor17
esophageal tumor57
gastrointestinal tumor42
germ cell tumor34
glioma18
head and neck tumor29
kidney tumor43
leukemia21
liver tumor41
lung tumor29
non-neoplasia31
primitive neuroectodermal tumor of the CNS7
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor23
Developmental Stage
TissuesTPM*
adult24
embryoid body28
blastocyst16
neonate193
fetus37
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.8
adrenal gland14.3
appendix11.5
bone marrow8.5
cerebral cortex16.5
colon8.7
duodenum8.7
esophagus10.5
gallbladder10.4
heart muscle6.7
kidney10.1
liver5.6
lung13.4
lymph node12.9
ovary8.1
pancreas5.6
placenta10.1
prostate10.9
salivary gland9.7
skin9.9
small intestine10.2
spleen10.6
stomach10.3
testis17.8
thyroid gland14.4
urinary bladder11.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
cerebellumHigh
cerebral cortexHigh
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusHigh
kidneyMedium
lateral ventricleHigh
lymph nodeMedium
pancreasMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606909, gene) Vesicle-associated membrane protein 4; VAMP4OMIM


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