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> Protein (NX_O75385)
Protein (NX_O75385)
Protein
Gene SymbolULK1 to neXtProt (NX_O75385)
DescriptionSerine/threonine-protein kinase ULK1
Chromosome12
Location12q24.33 (132379196 ~ 132407712) to Ensembl
Sequene Features : Isoforms 1, Variants 133, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of neurotrophin TRK receptor signaling pathway
.axon extension
.negative regulation of collateral sprouting
  + 15 more...
.protein complex binding
.Rab GTPase binding
.ATP binding
.protein serine/threonine kinase activity
.extrinsic component of autophagic vacuole membrane
.extrinsic component of pre-autophagosomal structure membrane
.extrinsic component of omegasome membrane
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 133 18
2014-09-19protein level
1 96 18
2014-05-27protein level
1 96 18
2014-02-25protein level
1 95 18
2013-12-09protein level
1 70 18
2013-11-01protein level
1 67 18
2013-09-12protein level
1 67 19
2013-08-17protein level
1 67 19
2013-07-15protein level
1 49 19
2013-06-11protein level
1 49 19
2013-02-12protein level
1 27 15
2012-12-20protein level
1 25 15
2012-10-30protein level
1 29 15
2012-10-07protein level
1 29 15
2012-08-24protein level
1 28 15
2012-07-28protein level
1 28 15
2012-06-08protein level
1 28 15
2012-05-07protein level
1 27 15
2012-04-10protein level
1 27 15
2012-01-13protein level
1 17 15
2011-12-20protein level
1 17 15
2011-11-11protein level
1 17 17
2011-08-23protein level
1 17 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75385-1
45 0 1 112560.1185
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-908831,EBI-2798775 ATG13  
  .positive regulation of protein targeting to mitochondrion
.activation of mitophagy in response to mitochondrial depolarization
.autophagic vacuole assembly
.protein kinase binding .ULK1-ATG13-FIP200 complex
.ATG1/UKL1 signaling complex
.cytosol
  + 2 more...
2 EBI-908831,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
3 EBI-908831,EBI-1047793 RB1CC1  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of cell size
.regulation of autophagy
  + 8 more...
.protein kinase binding .ULK1-ATG13-FIP200 complex
.ATG1/UKL1 signaling complex
.pre-autophagosomal structure membrane
  + 3 more...
4 EBI-908831,EBI-2603996 MAP1LC3C  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
5 EBI-908831,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
6 EBI-908831,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
7 EBI-908831,EBI-2797718 TBC1D14  
  .regulation of autophagic vacuole assembly
.recycling endosome to Golgi transport
.negative regulation of autophagy
.protein kinase binding
.GTPase activator activity
.recycling endosome
.Golgi apparatus
.autophagic vacuole
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites125
bladder33
blood32
brain57
cervix82
connective tissue13
embryonic tissue89
eye47
heart89
intestine68
kidney56
larynx42
lung68
lymph node33
mammary gland39
mouth15
muscle9
nerve64
ovary187
pancreas93
parathyroid97
placenta42
prostate31
salivary gland49
skin42
spleen74
testis29
thymus37
thyroid42
trachea19
uterus60
Health State
TissuesTPM*
normal47
adrenal tumor79
breast (mammary gland) tumor42
cervical tumor86
chondrosarcoma60
colorectal tumor26
gastrointestinal tumor50
germ cell tumor45
glioma121
head and neck tumor37
kidney tumor72
leukemia95
lung tumor97
lymphoma13
non-neoplasia72
ovarian tumor105
pancreatic tumor95
primitive neuroectodermal tumor of the CNS70
prostate cancer28
retinoblastoma21
skin tumor55
soft tissue/muscle tissue tumor31
uterine tumor55
Developmental Stage
TissuesTPM*
adult52
embryoid body100
blastocyst97
fetus44
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.6
adrenal gland17.7
appendix8.7
bone marrow39.4
cerebral cortex10.8
colon7
duodenum10.7
esophagus8.4
gallbladder14
heart muscle13
kidney10.8
liver6.7
lung13.5
lymph node8.7
ovary16
pancreas27.2
placenta10.5
prostate17.4
salivary gland14.1
skin24.1
small intestine10.3
spleen21.2
stomach12.1
testis16.6
thyroid gland8.6
urinary bladder9.6
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*603168, gene) Unc51-like kinase 1; ULK1OMIM


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