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> Protein (NX_O75386)
Protein (NX_O75386)
Protein
Gene SymbolTULP3 to neXtProt (NX_O75386)
DescriptionTubby-related protein 3
Chromosome12
Location12p13.33 (2986389 ~ 3050306) to Ensembl
Sequene Features : Isoforms 3, Variants 86, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.ganglion development
.smoothened signaling pathway involved in dorsal/ventral neural tube patterning
  + 14 more...
.phosphatidylinositol binding
.protein complex binding
.enzyme binding
.phosphatidylinositol-4,5-bisphosphate binding
.ciliary base
.primary cilium
.axoneme
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 86 3
2014-09-19protein level
3 67 3
2014-05-27protein level
2 64 3
2014-02-25protein level
1 61 3
2013-12-09protein level
1 45 3
2013-11-01protein level
1 42 1
2013-09-12protein level
1 42 1
2013-08-17protein level
1 42 1
2013-07-15protein level
1 33 1
2013-06-11protein level
1 33 1
2013-02-12protein level
1 19 1
2012-12-20protein level
1 17 1
2012-10-30protein level
1 22 1
2012-10-07protein level
1 22 1
2012-08-24protein level
1 22 1
2012-07-28protein level
1 21 1
2012-06-08protein level
1 27 1
2012-05-07protein level
1 24 1
2012-04-10protein level
1 24 1
2012-01-13protein level
1 14 1
2011-12-20protein level
1 14 1
2011-11-11protein level
1 14 1
2011-08-23protein level
1 14 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75386-1
1 14 0 49610.7524
NX_O75386-2
4 14 0 56509.3161
NX_O75386-3
2 2 0 19260.4179
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-5357290,EBI-1050964 PSTPIP1  
  .innate immune response
.nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
.signal transduction
  + 3 more...
.N/A .perinuclear region of cytoplasm
.cleavage furrow
.lamellipodium
  + 5 more...
2 EBI-5357290,EBI-1045155 MAGEA6  
  .N/A .N/A .N/A
3 EBI-5357290,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
4 EBI-5357290,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
5 EBI-5357290,EBI-10102770 ANKRD54  
  .regulation of intracellular signal transduction
.positive regulation of erythrocyte differentiation
.nucleocytoplasmic transport
.protein kinase regulator activity .midbody
.cytoplasm
.nucleus
6 EBI-5357290,EBI-1378139 ROPN1  
  .small GTPase mediated signal transduction .N/A .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood16
bone55
bone marrow20
brain13
cervix82
connective tissue26
embryonic tissue14
eye33
heart22
intestine21
kidney9
larynx85
liver24
lung41
mammary gland19
mouth15
ovary108
pancreas9
pituitary gland60
placenta14
prostate5
skin9
stomach41
testis36
thymus12
thyroid42
umbilical cord72
uterus56
Health State
TissuesTPM*
normal19
breast (mammary gland) tumor32
chondrosarcoma36
colorectal tumor8
gastrointestinal tumor42
germ cell tumor98
glioma46
head and neck tumor29
liver tumor10
non-neoplasia31
ovarian tumor118
prostate cancer9
retinoblastoma21
skin tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult35
embryoid body42
neonate96
fetus16
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.5
adrenal gland12.6
appendix7.7
bone marrow1.7
cerebral cortex7.2
colon7.3
duodenum5.5
esophagus14.2
gallbladder14.4
heart muscle9.3
kidney12.7
liver3.6
lung11.2
lymph node6.3
ovary39.5
pancreas3.9
placenta13.5
prostate11.3
salivary gland5.9
skin17.7
small intestine5.4
spleen8.2
stomach7.7
testis15.1
thyroid gland13.7
urinary bladder12.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604730, gene) Tubby-like protein 3; TULP3OMIM


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