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> Protein (NX_O75400)
Protein (NX_O75400)
Protein
Gene SymbolPRPF40A to neXtProt (NX_O75400)
DescriptionPre-mRNA-processing factor 40 homolog A
Chromosome2
Location2q23.3 (153508107 ~ 153574511) to Ensembl
Sequene Features : Isoforms 4, Variants 67, PTMs 19 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.regulation of cytokinesis
.cell migration
  + 5 more...
.poly(A) RNA binding .nuclear speck
.nuclear matrix
.membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 67 19
2014-09-19protein level
4 48 19
2014-05-27protein level
4 48 19
2014-02-25protein level
4 48 17
2013-12-09protein level
4 42 17
2013-11-01protein level
4 42 14
2013-09-12protein level
4 42 19
2013-08-17protein level
4 42 19
2013-07-15protein level
4 23 18
2013-06-11protein level
4 23 18
2013-02-12protein level
4 4 49
2012-12-20protein level
4 5 49
2012-10-30protein level
4 5 49
2012-10-07protein level
4 5 17
2012-08-24protein level
4 2 17
2012-07-28protein level
4 2 17
2012-06-08protein level
4 3 17
2012-05-07protein level
4 3 17
2012-04-10protein level
4 3 17
2012-01-13protein level
4 3 17
2011-12-20protein level
4 4 17
2011-11-11protein level
4 4 16
2011-08-23protein level
4 4 16
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75400-1
0 31 1 108736.2668
NX_O75400-2
0 29 1 105859.927
NX_O75400-3
1 29 1 106839.2666
NX_O75400-5
1 2 0 10688.6629
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-5280197,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-473291,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
3 EBI-473291,EBI-523590 CHD3  
  .centrosome organization
.DNA duplex unwinding
.chromatin modification
  + 6 more...
.poly(A) RNA binding
.zinc ion binding
.ATP binding
  + 3 more...
.intermediate filament cytoskeleton
.NuRD complex
.centrosome
  + 4 more...
4 EBI-5280197,EBI-395290 RBM39  
  .RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
5 EBI-473291,EBI-1054743 SF3A1  
  .gene expression
.RNA splicing
.mRNA processing
  + 3 more...
.poly(A) RNA binding
.RNA binding
.catalytic step 2 spliceosome
.U2-type prespliceosome
.U2 snRNP
  + 3 more...
6 EBI-473291,EBI-721539 NKAP  
  .positive regulation of protein targeting to mitochondrion
.hematopoietic stem cell proliferation
.positive regulation of alpha-beta T cell differentiation
  + 7 more...
.poly(A) RNA binding
.chromatin DNA binding
.chromatin binding
.cytoplasm
.nucleoplasm
7 EBI-5280197,EBI-742426 SDCBP2  
  .intracellular transport
.intracellular signal transduction
.nervous system development
.protein heterodimerization activity
.protein homodimerization activity
.protein C-terminus binding
.extracellular exosome
.plasma membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites125
bladder66
blood114
bone111
bone marrow102
brain34
cervix82
connective tissue40
embryonic tissue131
esophagus99
eye62
heart55
intestine77
kidney99
larynx127
liver151
lung98
lymph22
lymph node122
mammary gland99
mouth30
muscle18
ovary108
pancreas56
parathyroid145
pharynx98
placenta21
prostate52
salivary gland49
skin80
spleen74
stomach83
testis62
thymus37
trachea19
umbilical cord145
uterus73
vascular116
Health State
TissuesTPM*
normal71
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor115
chondrosarcoma120
colorectal tumor115
esophageal tumor115
gastrointestinal tumor101
germ cell tumor83
glioma74
head and neck tumor37
kidney tumor43
leukemia74
liver tumor177
lung tumor38
lymphoma13
non-neoplasia41
ovarian tumor118
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
prostate cancer48
retinoblastoma64
skin tumor119
soft tissue/muscle tissue tumor47
uterine tumor66
Developmental Stage
TissuesTPM*
adult76
embryoid body142
blastocyst97
neonate96
fetus77
infant85
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17.1
adrenal gland22.7
appendix36.1
bone marrow45.9
cerebral cortex18.8
colon28.4
duodenum26.6
esophagus31
gallbladder22.4
heart muscle14.3
kidney23.5
liver21.2
lung20.7
lymph node36.7
ovary22.4
pancreas13.5
placenta26.8
prostate25.7
salivary gland17.2
skin22.4
small intestine29
spleen32.9
stomach37.6
testis39.7
thyroid gland28.5
urinary bladder32.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleHigh
hippocampusLow
kidneyHigh
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeMedium
nasopharynxLow
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1Low
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Low
spleenLow
stomach 1High
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612941, gene) Precursor mrna-processing factor 40, s. cerevisiae, homolog of, a;OMIM


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