Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_O75410)
Protein (NX_O75410)
Protein
Gene SymbolTACC1 to neXtProt (NX_O75410)
DescriptionTransforming acidic coiled-coil-containing protein 1
Chromosome8
Location8p11.22 (38585704 ~ 38710546) to Ensembl
Sequene Features : Isoforms 8, Variants 90, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.regulation of microtubule-based process
.interkinetic nuclear migration
  + 5 more...
.N/A .intermediate filament cytoskeleton
.microtubule cytoskeleton
.microtubule organizing center
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 90 13
2014-09-19protein level
8 71 13
2014-05-27protein level
8 71 14
2014-02-25protein level
8 71 14
2013-12-09protein level
8 47 14
2013-11-01protein level
8 46 14
2013-09-12protein level
8 46 14
2013-08-17protein level
8 46 14
2013-07-15protein level
8 37 12
2013-06-11protein level
8 37 12
2013-02-12protein level
8 23 41
2012-12-20protein level
8 23 41
2012-10-30protein level
8 29 41
2012-10-07protein level
8 29 12
2012-08-24protein level
8 27 12
2012-07-28protein level
8 26 12
2012-06-08protein level
8 31 12
2012-05-07protein level
8 26 12
2012-04-10protein level
8 26 12
2012-01-13protein level
8 16 12
2011-12-20protein level
8 16 12
2011-11-11protein level
8 16 10
2011-08-23protein level
8 15 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75410-1
0 35 2 87739.9699
NX_O75410-2
1 36 2 89162.7241
NX_O75410-3
1 24 2 67031.2262
NX_O75410-4
1 17 2 42299.9886
NX_O75410-5
1 16 2 40877.2344
NX_O75410-6
0 17 2 43956.6171
NX_O75410-7
1 31 2 79822.5916
NX_O75410-8
0 6 1 17804.1509
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-624237,EBI-2828217 PRKRIR  
  .negative regulation of cell proliferation
.signal transduction
.response to stress
.metal ion binding
.DNA binding
.nucleus
2 EBI-624237,EBI-399269 YEATS4  
  .positive regulation of transcription, DNA-templated
.histone H2A acetylation
.histone H4 acetylation
  + 4 more...
.protein C-terminus binding
.structural constituent of cytoskeleton
.sequence-specific DNA binding transcription factor activity
.DNA binding
.NuA4 histone acetyltransferase complex
.nuclear matrix
.cytoplasm
  + 2 more...
3 EBI-624237,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
4 EBI-624252,EBI-624585 SNRPG  
  .ncRNA metabolic process
.mRNA 3'-end processing
.gene expression
  + 7 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.SMN-Sm protein complex
.methylosome
  + 9 more...
5 EBI-624237,EBI-714206 STX5  
  .regulation of Golgi organization
.Golgi disassembly
.vesicle fusion with Golgi apparatus
  + 7 more...
.protein N-terminus binding
.SNAP receptor activity
.SNARE binding
.endoplasmic reticulum-Golgi intermediate compartment membrane
.vesicle
.SNARE complex
  + 5 more...
6 EBI-624252,EBI-310585 CKAP5  
  .cell division
.centrosome organization
.RNA transport
  + 7 more...
.N/A .protein complex
.membrane
.cytosol
  + 2 more...
7 EBI-624237,EBI-624505 TDRD7  
  .lens fiber cell differentiation
.posttranscriptional regulation of gene expression
.spermatogenesis
  + 2 more...
.mRNA binding .P granule
.ribonucleoprotein granule
.chromatoid body
  + 2 more...
8 EBI-624278,EBI-624291 AURKB  
  .regulation of chromosome segregation
.mitotic spindle midzone assembly
.protein autophosphorylation
  + 20 more...
.metal ion binding
.histone serine kinase activity
.ATP binding
  + 2 more...
.spindle midzone
.chromosome passenger complex
.spindle pole centrosome
  + 8 more...
9 EBI-624237,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
10 EBI-624252,EBI-348372 LSM7  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.mRNA splicing, via spliceosome
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.U6 snRNA binding .cytosol
.small nucleolar ribonucleoprotein complex
.spliceosomal complex
11 EBI-624237,EBI-307461 BTRC  
  .cellular response to organic cyclic compound
.regulation of proteasomal protein catabolic process
.branching involved in mammary gland duct morphogenesis
  + 28 more...
.ligase activity
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.cytosol
.nucleoplasm
12 EBI-624237,EBI-1104564 MEMO1  
  .regulation of microtubule-based process .N/A .cytosol
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland182
ascites125
bladder167
blood89
bone111
bone marrow61
brain111
cervix61
connective tissue120
ear186
embryonic tissue46
eye119
heart212
intestine133
kidney109
liver102
lung116
lymph112
lymph node323
mammary gland112
mouth105
muscle75
nerve257
ovary128
pancreas121
parathyroid339
pharynx98
pituitary gland121
placenta120
prostate131
skin113
spleen262
stomach73
testis71
thymus87
thyroid64
trachea231
umbilical cord217
uterus159
vascular425
Health State
TissuesTPM*
normal153
adrenal tumor316
bladder carcinoma56
breast (mammary gland) tumor118
cervical tumor86
chondrosarcoma181
colorectal tumor79
gastrointestinal tumor84
germ cell tumor45
glioma27
head and neck tumor59
kidney tumor58
leukemia95
liver tumor135
lung tumor9
lymphoma110
non-neoplasia41
ovarian tumor105
pancreatic tumor85
primitive neuroectodermal tumor of the CNS7
prostate cancer86
skin tumor39
soft tissue/muscle tissue tumor63
uterine tumor55
Developmental Stage
TissuesTPM*
adult137
embryoid body85
blastocyst16
neonate160
fetus141
infant127
juvenile269
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue171.5
adrenal gland44.9
appendix55.2
bone marrow70.3
cerebral cortex54.5
colon57
duodenum26.4
esophagus104.7
gallbladder78.8
heart muscle47.4
kidney55.6
liver19.1
lung92.6
lymph node56
ovary51.6
pancreas28.5
placenta77.8
prostate66.7
salivary gland14.2
skin13.6
small intestine34.1
spleen76.2
stomach28.4
testis46.4
thyroid gland49.2
urinary bladder77
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605301, gene) Transforming, acidic, coiled-coil-containing protein 1; TACC1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center