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> Protein (NX_O75427)
Protein (NX_O75427)
Protein
Gene SymbolLRCH4 to neXtProt (NX_O75427)
DescriptionLeucine-rich repeat and calponin homology domain-containing protein 4
Chromosome7
Location7q22.1 (100169855 ~ 100183776) to Ensembl
Sequene Features : Isoforms 1, Variants 88, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nervous system development .N/A .PML body
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 88 9
2014-09-19protein level
1 67 9
2014-05-27protein level
1 67 9
2014-02-25protein level
1 67 9
2013-12-09protein level
1 50 9
2013-11-01protein level
1 44 9
2013-09-12protein level
1 44 9
2013-08-17protein level
1 44 9
2013-07-15protein level
1 32 9
2013-06-11protein level
1 32 9
2013-02-12protein level
1 20 8
2012-12-20protein level
1 21 8
2012-10-30protein level
1 26 8
2012-10-07protein level
1 26 8
2012-08-24protein level
1 23 8
2012-07-28protein level
1 23 8
2012-06-08protein level
1 27 8
2012-05-07protein level
1 26 8
2012-04-10protein level
1 26 8
2012-01-13protein level
1 13 8
2011-12-20protein level
1 13 8
2011-11-11protein level
1 13 8
2011-08-23protein level
1 13 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75427-1
30 0 0 73404.8213
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-718707,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
2 EBI-718707,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
3 EBI-718707,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
4 EBI-718707,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
5 EBI-718707,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
6 EBI-718707,EBI-307008 SUGT1  
  .innate immune response
.nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
.mitotic nuclear division
.N/A .cytosol
.cytoplasm
.nucleus
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites50
bladder33
blood196
bone27
bone marrow82
brain63
cervix61
connective tissue20
embryonic tissue56
eye62
heart11
intestine38
kidney75
larynx42
liver4
lung68
lymph67
lymph node111
mammary gland85
mouth15
muscle28
nerve64
ovary49
pancreas23
placenta38
prostate89
salivary gland148
skin52
spleen280
stomach10
testis183
thymus188
thyroid42
tonsil117
trachea19
uterus43
vascular96
Health State
TissuesTPM*
normal79
bladder carcinoma56
breast (mammary gland) tumor96
cervical tumor28
chondrosarcoma36
colorectal tumor8
gastrointestinal tumor25
germ cell tumor98
glioma46
head and neck tumor29
leukemia116
lung tumor68
lymphoma96
non-neoplasia62
ovarian tumor39
pancreatic tumor28
primitive neuroectodermal tumor of the CNS23
prostate cancer9
retinoblastoma21
skin tumor71
soft tissue/muscle tissue tumor31
uterine tumor55
Developmental Stage
TissuesTPM*
adult57
embryoid body42
blastocyst65
neonate32
fetus43
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.1
adrenal gland23.4
appendix49.9
bone marrow71.5
cerebral cortex12.9
colon16.6
duodenum31.4
esophagus15.2
gallbladder28.8
heart muscle11.7
kidney17.1
liver8.6
lung36.8
lymph node63.6
ovary23.3
pancreas13.8
placenta22.7
prostate25.4
salivary gland35.4
skin22.4
small intestine31.3
spleen90.9
stomach28
testis70.7
thyroid gland20.3
urinary bladder19.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
bronchusMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisLow
fallopian tubeMedium
gallbladderHigh
heart muscleLow
kidneyLow
lungMedium
lymph nodeMedium
nasopharynxMedium
pancreasMedium
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilHigh
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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