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> Protein (NX_O75460)
Protein (NX_O75460)
Protein
Gene SymbolERN1 to neXtProt (NX_O75460)
DescriptionSerine/threonine-protein kinase/endoribonuclease IRE1
Chromosome17
Location17q23.3 (62116502 ~ 62208179) to Ensembl
Sequene Features : Isoforms 2, Variants 103, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.peptidyl-serine trans-autophosphorylation
.insulin metabolic process
.positive regulation of endoplasmic reticulum unfolded protein response
  + 23 more...
.Hsp90 protein binding
.ADP binding
.protein homodimerization activity
  + 7 more...
.IRE1-RACK1-PP2A complex
.IRE1-TRAF2-ASK1 complex
.Ire1 complex
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 103 2
2014-09-19protein level
2 73 2
2014-05-27protein level
2 73 2
2014-02-25protein level
2 71 2
2013-12-09protein level
2 44 2
2013-11-01protein level
2 43 2
2013-09-12protein level
2 43 2
2013-08-17protein level
2 43 2
2013-07-15protein level
2 30 2
2013-06-11protein level
2 30 2
2013-02-12protein level
2 16 6
2012-12-20protein level
2 14 6
2012-10-30protein level
2 25 6
2012-10-07protein level
2 25 6
2012-08-24protein level
2 23 6
2012-07-28protein level
2 23 6
2012-06-08protein level
2 18 6
2012-05-07protein level
2 18 6
2012-04-10protein level
2 18 6
2012-01-13protein level
2 18 6
2011-12-20protein level
2 18 6
2011-11-11protein level
2 18 6
2011-08-23protein level
2 18 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75460-1
42 0 0 109665.3833
NX_O75460-2
4 0 0 6644.5793
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-371750,EBI-516580 BAX  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of apoptotic signaling pathway
  + 87 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.BAX complex
.Bcl-2 family protein complex
.extracellular exosome
  + 10 more...
2 EBI-371750,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
3 EBI-371750,EBI-947849 SYVN1  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.cellular protein metabolic process
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 6 more...
.ubiquitin protein ligase activity
.acid-amino acid ligase activity
.zinc ion binding
.integral component of membrane
.membrane
.endoplasmic reticulum membrane
  + 3 more...
4 EBI-371750,EBI-1384100 TAOK3  
  .protein autophosphorylation
.positive regulation of JNK cascade
.negative regulation of JNK cascade
  + 11 more...
.transferase activity
.ATP binding
.protein kinase inhibitor activity
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bladder33
blood16
bone marrow20
brain2
embryonic tissue4
eye4
intestine17
kidney9
liver4
lung38
lymph node11
mammary gland19
muscle28
nerve64
ovary9
pancreas23
placenta3
prostate15
skin4
spleen18
testis4
thymus12
uterus4
vascular58
Health State
TissuesTPM*
normal3
colorectal tumor26
germ cell tumor3
liver tumor20
lung tumor9
non-neoplasia10
pancreatic tumor47
prostate cancer9
retinoblastoma21
skin tumor7
Developmental Stage
TissuesTPM*
adult4
embryoid body14
fetus1
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.3
adrenal gland38.7
appendix9.6
bone marrow13.3
cerebral cortex1.8
colon6.8
duodenum7.5
esophagus5
gallbladder10.4
heart muscle2.2
kidney4.1
liver7.7
lung9.2
lymph node8.7
ovary7.8
pancreas35.9
placenta6.7
prostate7.7
salivary gland15.3
skin7.3
small intestine9
spleen11
stomach12.1
testis3
thyroid gland14.9
urinary bladder7.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604033, gene) Endoplasmic reticulum-to-nucleus signaling 1; ERN1OMIM


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