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> Protein (NX_O75478)
Protein (NX_O75478)
Protein
Gene SymbolTADA2A to neXtProt (NX_O75478)
DescriptionTranscriptional adapter 2-alpha
Chromosome17
Location17q12 (35766965 ~ 35839835) to Ensembl
Sequene Features : Isoforms 2, Variants 56, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H3 acetylation
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.chromatin organization
.zinc ion binding
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.chromosome
.nucleus
.PCAF complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 56 4
2014-09-19protein level
2 44 4
2014-05-27protein level
2 44 4
2014-02-25protein level
2 44 4
2013-12-09protein level
2 33 4
2013-11-01protein level
2 31 4
2013-09-12protein level
2 31 4
2013-08-17protein level
2 31 4
2013-07-15protein level
2 16 1
2013-06-11protein level
2 16 1
2013-02-12protein level
2 11 0
2012-12-20protein level
2 12 0
2012-10-30protein level
2 19 0
2012-10-07protein level
2 19 0
2012-08-24protein level
2 18 0
2012-07-28protein level
2 18 0
2012-06-08protein level
2 23 0
2012-05-07protein level
2 20 0
2012-04-10protein level
2 20 0
2012-01-13protein level
2 13 0
2011-12-20protein level
2 13 0
2011-11-11protein level
2 13 0
2011-08-23protein level
2 13 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75478-1
7 13 0 51472.4892
NX_O75478-2
3 13 0 36030.3301
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742268,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
2 EBI-742268,EBI-7415268 MTX2  
  .cellular protein metabolic process
.mitochondrial transport
.protein targeting to mitochondrion
.N/A .mitochondrial outer membrane
3 EBI-742268,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
4 EBI-742268,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
5 EBI-742268,EBI-299134 MAGOH  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 7 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.exon-exon junction complex
.nuclear speck
  + 3 more...
6 EBI-742268,EBI-1051880 SF3A3  
  .gene expression
.RNA splicing
.mRNA processing
  + 3 more...
.poly(A) RNA binding
.zinc ion binding
.catalytic step 2 spliceosome
.nuclear speck
.spliceosomal complex
.nucleoplasm
7 EBI-742268,EBI-10238588 FAM127C  
  .N/A .N/A .N/A
8 EBI-742268,EBI-6426443 KLHL38  
  .N/A .N/A .N/A
9 EBI-742268,EBI-10248148 -  
  .N/A .N/A .N/A
10 EBI-742268,EBI-6447954 TTC23  
  .N/A .N/A .N/A
11 EBI-742268,EBI-2851213 TTC9C  
  .N/A .N/A .N/A
12 EBI-742268,EBI-10273713 ZNF564  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
13 EBI-742268,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
14 EBI-742268,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
15 EBI-742268,EBI-750487 TEKT4  
  .cell projection organization .N/A .motile cilium
.microtubule
.cytoplasm
.nucleus
16 EBI-742268,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
17 EBI-742268,EBI-10293968 PPP1R16B  
  .positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
.negative regulation of peptidyl-serine dephosphorylation
.establishment of endothelial barrier
  + 6 more...
.protein phosphatase type 1 regulator activity .perinuclear region of cytoplasm
.cell projection
.plasma membrane
.nucleus
18 EBI-742268,EBI-949319 KLC4  
  .N/A .microtubule motor activity .microtubule
.kinesin complex
.cytoplasm
19 EBI-742268,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
20 EBI-742268,EBI-347538 GPSM3  
  .regulation of G-protein coupled receptor protein signaling pathway .GDP-dissociation inhibitor activity .cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood73
bone13
brain21
cervix61
embryonic tissue4
eye14
intestine4
kidney18
lung2
lymph node22
mammary gland6
mouth15
muscle37
ovary9
pharynx73
placenta14
prostate15
skin9
testis16
thymus37
uterus17
Health State
TissuesTPM*
normal17
adrenal tumor79
cervical tumor86
chondrosarcoma12
colorectal tumor8
germ cell tumor41
glioma9
head and neck tumor14
kidney tumor29
leukemia31
lymphoma55
primitive neuroectodermal tumor of the CNS47
prostate cancer9
retinoblastoma43
soft tissue/muscle tissue tumor23
uterine tumor22
Developmental Stage
TissuesTPM*
adult15
fetus21
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.1
adrenal gland6.2
appendix10.5
bone marrow6.4
cerebral cortex12.5
colon9.7
duodenum7.8
esophagus7.2
gallbladder6.3
heart muscle6.5
kidney7
liver4.9
lung8.4
lymph node12.2
ovary9
pancreas3.8
placenta10.3
prostate8
salivary gland4.9
skin8.5
small intestine9
spleen9.4
stomach8.9
testis21.1
thyroid gland13.6
urinary bladder9.6
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*602276, gene) Transcriptional adaptor 2a; TADA2AOMIM


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