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> Protein (NX_O75506)
Protein (NX_O75506)
Protein
Gene SymbolHSBP1 to neXtProt (NX_O75506)
DescriptionHeat shock factor-binding protein 1
Chromosome16
Location16q23.3 (83841448 ~ 83853342) to Ensembl
Sequene Features : Isoforms 1, Variants 6, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cellular response to heat
.endodermal cell differentiation
.cellular response to heat
  + 2 more...
.transcription corepressor activity .cytoskeleton
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 6 0
2014-09-19protein level
1 5 0
2014-05-27protein level
1 5 0
2014-02-25protein level
1 5 0
2013-12-09protein level
1 3 0
2013-11-01protein level
1 3 0
2013-09-12protein level
1 3 0
2013-08-17protein level
1 3 0
2013-07-15protein level
1 2 0
2013-06-11protein level
1 2 0
2013-02-12protein level
1 0 0
2012-12-20protein level
1 0 0
2012-10-30protein level
1 1 0
2012-10-07protein level
1 1 0
2012-08-24protein level
1 1 0
2012-07-28protein level
1 1 0
2012-06-08protein level
1 7 0
2012-05-07protein level
1 7 0
2012-04-10protein level
1 7 0
2012-01-13protein level
1 9 0
2011-12-20protein level
1 9 0
2011-11-11protein level
1 9 0
2011-08-23protein level
1 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75506-1
3 0 0 8538.1508
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-748664,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-748664,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
3 EBI-748664,EBI-10188326 KIAA1217  
  .embryonic skeletal system development .N/A .cytoplasm
4 EBI-748664,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
5 EBI-748664,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
6 EBI-748664,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
7 EBI-748664,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
8 EBI-748664,EBI-712969 CCDC53  
  .protein transport .N/A .WASH complex
.intracellular membrane-bounded organelle
.actin cytoskeleton
.early endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland242
ascites175
bladder267
blood417
bone223
bone marrow307
brain260
cervix226
connective tissue134
ear372
embryonic tissue197
esophagus347
eye191
heart435
intestine163
kidney213
liver199
lung194
lymph45
lymph node111
mammary gland99
mouth30
muscle169
nerve193
ovary68
pancreas46
parathyroid631
pharynx122
pituitary gland181
placenta98
prostate68
salivary gland49
skin123
spleen37
stomach135
testis215
thymus50
thyroid42
trachea38
umbilical cord145
uterus185
vascular154
Health State
TissuesTPM*
normal205
adrenal tumor553
bladder carcinoma284
breast (mammary gland) tumor118
cervical tumor202
chondrosarcoma169
colorectal tumor186
esophageal tumor289
gastrointestinal tumor92
germ cell tumor341
glioma279
head and neck tumor22
kidney tumor261
leukemia169
liver tumor187
lung tumor29
lymphoma96
non-neoplasia269
ovarian tumor65
pancreatic tumor57
primitive neuroectodermal tumor of the CNS307
prostate cancer28
retinoblastoma366
skin tumor71
soft tissue/muscle tissue tumor143
uterine tumor88
Developmental Stage
TissuesTPM*
adult163
embryoid body142
blastocyst146
fetus350
infant935
juvenile197
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.6
adrenal gland64.4
appendix38.3
bone marrow23.5
cerebral cortex73
colon52
duodenum42
esophagus57.3
gallbladder45
heart muscle45.1
kidney61.7
liver26.2
lung45.9
lymph node31.3
ovary51.5
pancreas19.4
placenta41.6
prostate49.5
salivary gland34.8
skin24.6
small intestine43.6
spleen37.3
stomach41.9
testis48.7
thyroid gland67.5
urinary bladder48.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604553, gene) Heat-shock factor-binding protein 1; HSBP1OMIM


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