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> Protein (NX_O75528)
Protein (NX_O75528)
Protein
Gene SymbolTADA3 to neXtProt (NX_O75528)
DescriptionTranscriptional adapter 3
Chromosome3
Location3p25.3 (9821544 ~ 9834695) to Ensembl
Sequene Features : Isoforms 2, Variants 42, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of tubulin deacetylation
.positive regulation of transcription, DNA-templated
.histone H3 acetylation
  + 9 more...
.ligand-dependent nuclear receptor transcription coactivator activity
.protein domain specific binding
.ligand-dependent nuclear receptor binding
  + 2 more...
.mitotic spindle
.transcription factor TFTC complex
.STAGA complex
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 42 2
2014-09-19protein level
2 30 2
2014-05-27protein level
2 30 2
2014-02-25protein level
2 30 2
2013-12-09protein level
2 23 2
2013-11-01protein level
2 21 2
2013-09-12protein level
2 21 2
2013-08-17protein level
2 21 2
2013-07-15protein level
2 14 2
2013-06-11protein level
2 14 2
2013-02-12protein level
2 4 1
2012-12-20protein level
2 4 1
2012-10-30protein level
2 5 1
2012-10-07protein level
2 5 1
2012-08-24protein level
2 1 1
2012-07-28protein level
2 1 1
2012-06-08protein level
2 2 1
2012-05-07protein level
2 2 1
2012-04-10protein level
2 2 1
2012-01-13protein level
2 4 1
2011-12-20protein level
2 4 1
2011-11-11protein level
2 4 1
2011-08-23protein level
2 4 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75528-1
1 15 0 48872.1196
NX_O75528-2
0 15 0 41367.0498
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-473249,EBI-395261 CCNC  
  .positive regulation of transcription from RNA polymerase II promoter
.gene expression
.Notch signaling pathway
  + 4 more...
.N/A .mediator complex
.nucleoplasm
2 EBI-473249,EBI-741277 USP5  
  .protein K48-linked deubiquitination
.positive regulation of proteasomal ubiquitin-dependent protein catabolic process
.ubiquitin-dependent protein catabolic process
.zinc ion binding
.omega peptidase activity
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.lysosome
3 EBI-473249,EBI-473160 PIAS4  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.positive regulation of keratinocyte apoptotic process
.negative regulation of transcription, DNA-templated
  + 8 more...
.SUMO ligase activity
.ubiquitin protein ligase binding
.SUMO transferase activity
  + 3 more...
.PML body
.nuclear matrix
.cytoplasm
  + 2 more...
4 EBI-473249,EBI-743117 CCDC101  
  .establishment of protein localization to chromatin
.histone H3 acetylation
.regulation of transcription, DNA-templated
  + 2 more...
.methylated histone binding .SAGA-type complex
.Ada2/Gcn5/Ada3 transcription activator complex
5 EBI-473249,EBI-5460660 HEXIM2  
  .negative regulation of transcription, DNA-templated
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.snRNA binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites125
bladder33
blood122
bone167
bone marrow82
brain64
cervix247
connective tissue46
embryonic tissue84
eye158
heart44
intestine107
kidney104
larynx42
liver97
lung149
lymph203
lymph node55
mammary gland66
muscle131
ovary187
pancreas74
pharynx73
placenta151
prostate100
salivary gland49
skin90
spleen37
stomach20
testis119
thymus12
thyroid42
tonsil176
trachea19
uterus146
Health State
TissuesTPM*
normal57
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor96
cervical tumor289
chondrosarcoma120
colorectal tumor115
gastrointestinal tumor143
germ cell tumor113
glioma167
head and neck tumor37
kidney tumor232
leukemia84
liver tumor208
lung tumor311
lymphoma221
non-neoplasia62
ovarian tumor144
pancreatic tumor152
primitive neuroectodermal tumor of the CNS181
prostate cancer154
retinoblastoma323
skin tumor143
soft tissue/muscle tissue tumor191
uterine tumor177
Developmental Stage
TissuesTPM*
adult96
embryoid body42
blastocyst65
fetus44
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.3
adrenal gland43.5
appendix33.7
bone marrow21.4
cerebral cortex30.6
colon32.5
duodenum26.2
esophagus30.4
gallbladder34.4
heart muscle34
kidney28.2
liver14.7
lung32.8
lymph node43.5
ovary53.1
pancreas13.5
placenta20.9
prostate40.6
salivary gland25.9
skin23.3
small intestine28.3
spleen31.8
stomach30.4
testis49
thyroid gland42.4
urinary bladder42.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602945, gene) Transcriptional adaptor 3; TADA3OMIM


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