Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_O75553)
Protein (NX_O75553)
Protein
Gene SymbolDAB1 to neXtProt (NX_O75553)
DescriptionDisabled homolog 1
Chromosome1
Location1p32.1 (57460451 ~ 59012406) to Ensembl
Sequene Features : Isoforms 6, Variants 153, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 153 4
2014-09-19protein level
6 100 4
2014-05-27protein level
6 100 4
2014-02-25protein level
6 100 4
2013-12-09protein level
6 86 4
2013-11-01protein level
6 72 4
2013-09-12protein level
6 72 4
2013-08-17protein level
6 72 4
2013-07-15protein level
6 52 4
2013-06-11protein level
6 52 4
2013-02-12protein level
6 17 15
2012-12-20protein level
6 17 15
2012-10-30protein level
6 22 15
2012-10-07protein level
6 22 3
2012-08-24protein level
6 11 3
2012-07-28protein level
6 10 3
2012-06-08protein level
6 20 3
2012-05-07protein level
6 20 3
2012-04-10protein level
6 20 3
2012-01-13protein level
6 16 3
2011-12-20protein level
6 16 3
2011-11-11protein level
6 16 3
2011-08-23protein level
6 16 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75553-1
0 21 0 63735.1664
NX_O75553-2
1 8 0 24075.5232
NX_O75553-3
1 15 0 49824.2355
NX_O75553-4
1 17 0 57683.3335
NX_O75553-5
0 20 0 59574.2395
NX_O75553-6
1 17 0 59912.4327
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7875264,EBI-10179231 SIRPB1  
  .innate immune response
.cell surface receptor signaling pathway
.signal transduction
.N/A .extracellular exosome
.integral component of plasma membrane
.plasma membrane
2 EBI-7875264,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
3 EBI-7875264,EBI-746056 RBFOX2  
  .neuromuscular process controlling balance
.dendrite morphogenesis
.negative regulation of transcription, DNA-templated
  + 8 more...
.poly(A) RNA binding
.transcription factor binding
.mRNA binding
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
4 EBI-7875264,EBI-3913399 HYAL3  
  .cellular response to UV-B
.cellular response to tumor necrosis factor
.cellular response to interleukin-1
  + 6 more...
.hyaluronoglucuronidase activity
.hyalurononglucosaminidase activity
.cytoplasmic vesicle
.lysosome
.extracellular region
5 EBI-7875264,EBI-10191303 VENTX  
  .multicellular organismal development
.regulation of transcription, DNA-templated
.sequence-specific DNA binding .nucleus
6 EBI-7875264,EBI-372475 SNRPB  
  .activation of mitophagy in response to mitochondrial depolarization
.ncRNA metabolic process
.mRNA 3'-end processing
  + 9 more...
.histone pre-mRNA DCP binding
.poly(A) RNA binding
.histone pre-mRNA 3'end processing complex
.catalytic step 2 spliceosome
.U2-type prespliceosome
  + 14 more...
7 EBI-7875264,EBI-10172814 PRR20C  
  .N/A .N/A .N/A
8 EBI-7875264,EBI-396072 PPIG  
  .RNA splicing
.protein folding
.protein peptidyl-prolyl isomerization
.poly(A) RNA binding
.cyclosporin A binding
.peptidyl-prolyl cis-trans isomerase activity
.nuclear speck
.nuclear matrix
.cytoplasm
  + 2 more...
9 EBI-7875264,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
10 EBI-7875264,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
11 EBI-7875264,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
12 EBI-7875264,EBI-10240775 LGALS9B  
  .N/A .carbohydrate binding .N/A
13 EBI-7875264,EBI-1048945 KRTAP19-5  
  .N/A .N/A .intermediate filament
14 EBI-7875264,EBI-10241353 KRTAP19-7  
  .N/A .N/A .intermediate filament
15 EBI-7875264,EBI-9088829 LGALS9C  
  .N/A .carbohydrate binding .N/A
16 EBI-7875264,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
17 EBI-7875264,EBI-946029 C1orf94  
  .N/A .N/A .N/A
18 EBI-7875264,EBI-10188441 TMTC3  
  .bud outgrowth involved in lung branching
.muscle fiber development
.lung alveolus development
  + 2 more...
.N/A .integral component of membrane
19 EBI-7875264,EBI-1389308 POGZ  
  .kinetochore assembly
.cell division
.mitotic sister chromatid cohesion
.metal ion binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
.nuclear chromatin
20 EBI-7875264,EBI-10261141 KRTAP8-1  
  .N/A .N/A .intermediate filament
21 EBI-7875264,EBI-10265133 CIART  
  .negative regulation of transcription, DNA-templated
.locomotor rhythm
.circadian regulation of gene expression
.transcription, DNA-templated
.E-box binding
.core promoter sequence-specific DNA binding
.PML body
.nucleus
22 EBI-7875264,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
23 EBI-7875264,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
24 EBI-7875264,EBI-597063 ZCCHC10  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
25 EBI-7875264,EBI-2822515 SMAP2  
  .N/A .zinc ion binding
.GTPase activator activity
.cytoplasm
.nucleoplasm
26 EBI-7875264,EBI-535849 HNRNPLL  
  .positive regulation of RNA splicing
.mRNA processing
.poly(A) RNA binding
.mRNA binding
.nucleotide binding
.ribonucleoprotein complex
.membrane
.nucleus
27 EBI-7875264,EBI-7957930 FAM168A  
  .N/A .N/A .N/A
28 EBI-7875264,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
29 EBI-7875264,EBI-2515597 NAF1  
  .ribosome biogenesis
.rRNA processing
.pseudouridine synthesis
.poly(A) RNA binding
.RNA binding
.cytoplasm
.small nucleolar ribonucleoprotein complex
.nucleus
30 EBI-7875264,EBI-742550 ZC3H10  
  .N/A .metal ion binding
.poly(A) RNA binding
.N/A
31 EBI-7875264,EBI-948288 ZNF488  
  .positive regulation of oligodendrocyte differentiation
.negative regulation of transcription, DNA-templated
.oligodendrocyte development
  + 2 more...
.metal ion binding
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
32 EBI-7875264,EBI-740355 STRBP  
  .mechanosensory behavior
.spermatid development
.multicellular organismal development
.poly(A) RNA binding
.single-stranded RNA binding
.double-stranded RNA binding
.DNA binding
.microtubule cytoskeleton
.cytoplasm
.nucleus
33 EBI-7875264,EBI-372094 RHOXF2  
  .regulation of transcription, DNA-templated .sequence-specific DNA binding .nucleus
34 EBI-7875264,EBI-744023 FAM103A1  
  .recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
.methylation
.7-methylguanosine mRNA capping
.poly(A) RNA binding
.RNA binding
.mRNA cap binding complex
.nucleus
35 EBI-7875264,EBI-74615 TOLLIP  
  .leukocyte activation
.innate immune response
.protein localization to endosome
  + 8 more...
.Toll-like receptor binding
.kinase binding
.signal transducer activity
.extracellular exosome
.perinuclear region of cytoplasm
.interleukin-1 receptor complex
  + 4 more...
36 EBI-7875264,EBI-2805004 MBNL1  
  .myoblast differentiation
.regulation of RNA splicing
.embryonic limb morphogenesis
  + 7 more...
.metal ion binding
.poly(A) RNA binding
.double-stranded RNA binding
.RNA binding
.cytoplasmic stress granule
.centrosome
.cytoplasm
  + 2 more...
37 EBI-7875264,EBI-6661142 MBNL3  
  .negative regulation of myoblast differentiation
.regulation of RNA splicing
.RNA splicing
  + 2 more...
.metal ion binding
.poly(A) RNA binding
.cytoplasm
.nucleus
38 EBI-7875264,EBI-716006 MAGED1  
  .positive regulation of apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
  + 15 more...
.transcription coactivator activity .protein complex
.plasma membrane
.cytoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain43
connective tissue295
embryonic tissue23
eye9
kidney18
liver14
lung2
pancreas4
prostate15
testis2
Health State
TissuesTPM*
normal23
germ cell tumor15
kidney tumor58
soft tissue/muscle tissue tumor351
Developmental Stage
TissuesTPM*
adult30
blastocyst65
fetus66
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2
adrenal gland2.1
cerebral cortex4.8
duodenum18.2
gallbladder1.2
heart muscle1
liver3.7
ovary1.8
prostate3.5
small intestine25.2
stomach1.2
urinary bladder1.7
Tissues
TissuesExpression level
cerebellumMedium
cerebral cortexMedium
duodenumHigh
heart muscleLow
hippocampusLow
lateral ventricleLow
skeletal muscleLow
small intestineHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603448, gene) Disabled, drosophila, homolog of, 1; DAB1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center