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> Protein (NX_O75554)
Protein (NX_O75554)
Protein
Gene SymbolWBP4 to neXtProt (NX_O75554)
DescriptionWW domain-binding protein 4
Chromosome13
Location13q14.11 (41635410 ~ 41658137) to Ensembl
Sequene Features : Isoforms 2, Variants 41, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mRNA cis splicing, via spliceosome .proline-rich region binding
.zinc ion binding
.nucleic acid binding
.nuclear speck
.plasma membrane
.spliceosomal complex
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 41 3
2014-09-19protein level
1 36 3
2014-05-27protein level
1 36 3
2014-02-25protein level
1 36 3
2013-12-09protein level
1 26 3
2013-11-01protein level
1 25 3
2013-09-12protein level
1 25 3
2013-08-17protein level
1 25 3
2013-07-15protein level
1 13 3
2013-06-11protein level
1 13 3
2013-02-12protein level
1 7 3
2012-12-20protein level
1 7 3
2012-10-30protein level
1 10 3
2012-10-07protein level
1 10 3
2012-08-24protein level
1 10 3
2012-07-28protein level
1 10 3
2012-06-08protein level
1 13 3
2012-05-07protein level
1 12 3
2012-04-10protein level
1 12 3
2012-01-13protein level
1 6 3
2011-12-20protein level
1 6 3
2011-11-11protein level
1 6 3
2011-08-23protein level
1 6 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75554-1
1 12 0 42480.8221
NX_O75554-2
1 12 0 40005.5564
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7251981,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood24
bone55
bone marrow20
brain25
cervix61
connective tissue20
embryonic tissue51
esophagus49
eye14
heart33
intestine4
kidney42
liver14
lung65
lymph67
lymph node77
mammary gland6
muscle56
pancreas18
parathyroid48
pharynx24
placenta45
prostate26
salivary gland49
skin18
spleen18
stomach41
testis29
thymus62
tonsil58
trachea19
umbilical cord72
uterus21
vascular38
Health State
TissuesTPM*
normal38
cervical tumor86
chondrosarcoma72
colorectal tumor8
esophageal tumor57
gastrointestinal tumor25
germ cell tumor49
glioma9
leukemia21
liver tumor10
lymphoma55
pancreatic tumor19
prostate cancer19
skin tumor23
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult28
embryoid body57
blastocyst32
neonate32
fetus46
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.3
adrenal gland15.7
appendix10.7
bone marrow9.1
cerebral cortex14.4
colon8.7
duodenum9.4
esophagus11.8
gallbladder10
heart muscle18.4
kidney9.9
liver8.2
lung10.1
lymph node11.5
ovary11.6
pancreas4.1
placenta11.7
prostate13.2
salivary gland5.8
skin9.3
small intestine10.5
spleen8.7
stomach8.3
testis12.8
thyroid gland10.8
urinary bladder11.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604981, gene) Ww domain-containing binding protein 4; WBP4OMIM


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