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> Protein (NX_O75558)
Protein (NX_O75558)
Protein
Gene SymbolSTX11 to neXtProt (NX_O75558)
DescriptionSyntaxin-11
Chromosome6
Location6q24.2 (144471663 ~ 144509507) to Ensembl
Sequene Features : Isoforms 1, Variants 55, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 55 0
2014-09-19protein level
1 39 0
2014-05-27protein level
1 39 0
2014-02-25protein level
1 38 0
2013-12-09protein level
1 34 0
2013-11-01protein level
1 33 0
2013-09-12protein level
1 33 0
2013-08-17protein level
1 33 0
2013-07-15protein level
1 20 0
2013-06-11protein level
1 20 0
2013-02-12protein level
1 14 0
2012-12-20protein level
1 14 0
2012-10-30protein level
1 13 0
2012-10-07protein level
1 13 0
2012-08-24protein level
1 13 0
2012-07-28protein level
1 13 0
2012-06-08protein level
1 22 0
2012-05-07protein level
1 19 0
2012-04-10protein level
1 19 0
2012-01-13protein level
1 16 0
2011-12-20protein level
1 16 0
2011-11-11protein level
1 16 0
2011-08-23protein level
1 16 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75558-1
13 0 0 33174.7109
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-714135,EBI-745000 SNAP23  
  .membrane fusion
.membrane organization
.synaptic vesicle fusion to presynaptic membrane
  + 5 more...
.syntaxin binding
.SNAP receptor activity
.extracellular exosome
.synapse
.neuron projection
  + 8 more...
2 EBI-714135,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
3 EBI-714135,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
4 EBI-714135,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
5 EBI-714135,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
6 EBI-714135,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
7 EBI-714135,EBI-960169 STXBP1  
  .protein localization to plasma membrane
.platelet aggregation
.long term synaptic depression
  + 19 more...
.poly(A) RNA binding
.identical protein binding
.syntaxin binding
  + 2 more...
.extracellular exosome
.protein complex
.platelet alpha granule
  + 5 more...
8 EBI-714135,EBI-10224192 RUNX1T1  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.generation of precursor metabolites and energy
.metal ion binding
.identical protein binding
.transcription corepressor activity
  + 2 more...
.nuclear matrix
.mitochondrion
.cytoplasm
.nucleoplasm
9 EBI-714135,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
10 EBI-714135,EBI-10181260 GOLGA8F  
  .N/A .N/A .Golgi apparatus
11 EBI-714135,EBI-10181276 GOLGA8DP  
  .N/A .N/A .Golgi apparatus
12 EBI-714135,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
13 EBI-714135,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
14 EBI-714135,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
15 EBI-714135,EBI-10179526 CCDC184  
  .N/A .N/A .cytoplasm
16 EBI-714135,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
17 EBI-714135,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
18 EBI-714135,EBI-1643885 KLC3  
  .axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
19 EBI-714135,EBI-3923278 CCBE1  
  .positive regulation of lymphangiogenesis
.positive regulation of vascular endothelial growth factor signaling pathway
.venous blood vessel morphogenesis
  + 6 more...
.collagen binding
.calcium ion binding
.protease binding
.extracellular space
.collagen trimer
.proteinaceous extracellular matrix
20 EBI-714135,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
21 EBI-714135,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
22 EBI-714135,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
23 EBI-714135,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
24 EBI-714135,EBI-750700 EIF1AD  
  .N/A .translation initiation factor activity .intermediate filament cytoskeleton
.intracellular membrane-bounded organelle
.nucleoplasm
25 EBI-714135,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
26 EBI-714135,EBI-597063 ZCCHC10  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
27 EBI-714135,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
28 EBI-714135,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
29 EBI-714135,EBI-726510 LENG1  
  .N/A .N/A .N/A
30 EBI-714135,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
31 EBI-714135,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
32 EBI-714135,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
33 EBI-714135,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
34 EBI-714135,EBI-1752811 FAM110A  
  .N/A .N/A .microtubule organizing center
.cytoplasm
.spindle pole
35 EBI-714135,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
36 EBI-714135,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
37 EBI-714135,EBI-10182361 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
38 EBI-714135,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
39 EBI-714135,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
40 EBI-714135,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
41 EBI-714135,EBI-465781 BLOC1S6  
  .membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood57
bone marrow102
brain1
connective tissue6
intestine8
kidney18
lung11
lymph node178
mammary gland6
placenta45
testis4
uterus8
vascular19
Health State
TissuesTPM*
normal14
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor8
germ cell tumor11
glioma18
leukemia52
uterine tumor11
Developmental Stage
TissuesTPM*
adult18
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.4
adrenal gland4
appendix11.3
bone marrow87.9
colon2.8
duodenum1.6
esophagus3.1
gallbladder4.4
heart muscle3.3
kidney1.7
liver2.8
lung20
lymph node9.8
placenta6.3
skin2.2
small intestine2.5
spleen16.4
stomach2.5
testis1.6
thyroid gland4.8
urinary bladder4.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#603552, phenotype) Hemophagocytic lymphohistiocytosis, familial, 4; FHL4OMIM
2(*605014, gene) Syntaxin 11; STX11OMIM


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