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> Protein (NX_O75563)
Protein (NX_O75563)
Protein
Gene SymbolSKAP2 to neXtProt (NX_O75563)
DescriptionSrc kinase-associated phosphoprotein 2
Chromosome7
Location7p15.2 (26706681 ~ 27034858) to Ensembl
Sequene Features : Isoforms 1, Variants 58, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.B cell activation
.positive regulation of signal transduction
.negative regulation of cell proliferation
  + 2 more...
.SH3/SH2 adaptor activity .plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 58 3
2014-09-19protein level
1 40 3
2014-05-27protein level
1 40 3
2014-02-25protein level
1 41 3
2013-12-09protein level
1 34 3
2013-11-01protein level
1 30 3
2013-09-12protein level
1 30 4
2013-08-17protein level
1 30 4
2013-07-15protein level
1 22 4
2013-06-11protein level
1 22 4
2013-02-12protein level
1 13 5
2012-12-20protein level
1 13 5
2012-10-30protein level
1 14 5
2012-10-07protein level
1 14 5
2012-08-24protein level
1 6 5
2012-07-28protein level
1 6 5
2012-06-08protein level
1 8 5
2012-05-07protein level
1 8 5
2012-04-10protein level
1 8 5
2012-01-13protein level
1 7 5
2011-12-20protein level
1 7 5
2011-11-11protein level
1 7 5
2011-08-23protein level
1 7 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75563-1
19 0 0 41190.8444
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2483161,EBI-1211241 PTPN22  
  .negative regulation of T cell activation
.negative regulation of T cell receptor signaling pathway
.regulation of B cell receptor signaling pathway
  + 7 more...
.kinase binding
.SH3 domain binding
.protein tyrosine phosphatase activity
.perinuclear region of cytoplasm
.cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue1243
adrenal gland30
ascites25
bladder33
blood32
bone55
bone marrow20
brain19
cervix288
connective tissue4118
embryonic tissue23
esophagus297
eye19
heart22
intestine547
kidney18
larynx85
liver24
lung277
lymph6545
lymph node278
mammary gland39
mouth15
muscle131
ovary78
pancreas9
parathyroid97
pharynx466
placenta10
prostate5
salivary gland49
skin61
spleen1479
stomach783
testis11
thymus627
thyroid42
tonsil1233
trachea77
uterus60
vascular96
Health State
TissuesTPM*
normal123
adrenal tumor79
bladder carcinoma341
breast (mammary gland) tumor32
cervical tumor347
chondrosarcoma36
colorectal tumor97
esophageal tumor347
gastrointestinal tumor25
germ cell tumor364
glioma46
head and neck tumor14
kidney tumor43
leukemia10
liver tumor41
lung tumor797
lymphoma4155
non-neoplasia6354
ovarian tumor26
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
prostate cancer9
skin tumor55
soft tissue/muscle tissue tumor87
uterine tumor110
Developmental Stage
TissuesTPM*
adult36
embryoid body57
neonate193
fetus8
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue32.5
adrenal gland26.2
appendix34
bone marrow18.3
cerebral cortex14.2
colon26.2
duodenum19.5
esophagus38.1
gallbladder37
heart muscle5.7
kidney24.9
liver8
lung29.1
lymph node58.1
ovary25.8
pancreas4.4
placenta8.1
prostate9.3
salivary gland4.6
skin11.4
small intestine20.6
spleen37.1
stomach14.2
testis32.2
thyroid gland16.5
urinary bladder82.5
Tissues
TissuesExpression level
appendixMedium
bone marrowMedium
cerebral cortexLow
hippocampusLow
lateral ventricleLow
lungMedium
lymph nodeMedium
skeletal muscleMedium
spleenMedium
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605215, gene) Skap55-related proteinOMIM


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