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> Protein (NX_O75604)
Protein (NX_O75604)
Protein
Gene SymbolUSP2 to neXtProt (NX_O75604)
DescriptionUbiquitin carboxyl-terminal hydrolase 2
Chromosome11
Location11q23.3 (119225925 ~ 119252436) to Ensembl
Sequene Features : Isoforms 4, Variants 101, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of proteasomal protein catabolic process
.protein stabilization
.positive regulation of skeletal muscle tissue development
  + 11 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin binding
  + 2 more...
.perinuclear region of cytoplasm
.cell cortex
.centrosome
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 101 0
2014-09-19protein level
4 78 0
2014-05-27protein level
4 78 0
2014-02-25protein level
4 75 0
2013-12-09protein level
4 56 0
2013-11-01protein level
4 53 0
2013-09-12protein level
4 53 0
2013-08-17protein level
4 53 0
2013-07-15protein level
4 38 0
2013-06-11protein level
4 38 0
2013-02-12protein level
4 23 0
2012-12-20protein level
4 22 0
2012-10-30protein level
4 28 0
2012-10-07protein level
4 28 0
2012-08-24protein level
4 21 0
2012-07-28protein level
4 21 0
2012-06-08protein level
4 8 0
2012-05-07protein level
4 8 0
2012-04-10protein level
4 8 0
2012-01-13protein level
4 8 0
2011-12-20protein level
4 8 0
2011-11-11protein level
4 8 0
2011-08-23protein level
4 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75604-1
13 15 0 68028.6405
NX_O75604-2
0 15 0 40612.0205
NX_O75604-3
1 15 0 41655.5686
NX_O75604-4
2 15 0 45211.554
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-743272,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-743272,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
3 EBI-743272,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
4 EBI-743272,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
5 EBI-743272,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
6 EBI-743272,EBI-2808286 CCDC57  
  .N/A .N/A .N/A
7 EBI-743272,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
8 EBI-743272,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
9 EBI-743272,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
10 EBI-743272,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
11 EBI-743272,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
12 EBI-743272,EBI-2865388 LHX4  
  .negative regulation of apoptotic process
.medial motor column neuron differentiation
.organ morphogenesis
  + 4 more...
.sequence-specific DNA binding
.zinc ion binding
.nucleus
13 EBI-743272,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
14 EBI-743272,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
15 EBI-743272,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
16 EBI-743272,EBI-928842 NDEL1  
  .neuron projection extension
.neurofilament cytoskeleton organization
.centrosome localization
  + 20 more...
.oligopeptidase activity
.microtubule binding
.neurofilament cytoskeleton
.axon hillock
.cell leading edge
  + 10 more...
17 EBI-743272,EBI-746704 HOOK1  
  .early endosome to late endosome transport
.protein transport
.endosome to lysosome transport
  + 4 more...
.identical protein binding .FHF complex
.microtubule
18 EBI-743272,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone27
brain26
cervix20
esophagus99
eye47
heart22
kidney47
larynx42
liver14
lung8
lymph135
mammary gland13
mouth30
muscle65
ovary29
pancreas28
parathyroid145
skin14
testis243
thyroid21
Health State
TissuesTPM*
normal32
breast (mammary gland) tumor21
cervical tumor28
esophageal tumor115
germ cell tumor11
glioma27
head and neck tumor14
kidney tumor14
liver tumor20
lymphoma96
pancreatic tumor19
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult18
fetus32
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.9
adrenal gland8.2
appendix2.1
bone marrow1.3
cerebral cortex19
colon10.8
duodenum11.7
esophagus9.2
gallbladder2.9
heart muscle39.2
kidney35.8
liver18.2
lung3.1
ovary1.7
pancreas8.5
placenta1.2
prostate4.8
salivary gland4
skin4.7
small intestine15.6
stomach1.1
testis65.3
thyroid gland2.3
urinary bladder1.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxLow
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleMedium
skin 1Medium
skin 2Low
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604725, gene) Ubiquitin-specific protease 2; USP2OMIM


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