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> Protein (NX_O75674)
Protein (NX_O75674)
Protein
Gene SymbolTOM1L1 to neXtProt (NX_O75674)
DescriptionTOM1-like protein 1
Chromosome17
Location17q22 (52976748 ~ 53039310) to Ensembl
Sequene Features : Isoforms 2, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of mitotic nuclear division
.ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
.activation of protein kinase activity
  + 3 more...
.ubiquitin binding
.protein kinase activator activity
.clathrin binding
.protein kinase binding
.extracellular exosome
.endosome membrane
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 34 7
2014-09-19protein level
1 24 7
2014-05-27protein level
1 24 7
2014-02-25protein level
1 24 7
2013-12-09protein level
1 19 7
2013-11-01protein level
1 18 5
2013-09-12protein level
1 18 5
2013-08-17protein level
1 18 5
2013-07-15protein level
1 13 4
2013-06-11protein level
1 13 4
2013-02-12protein level
1 6 4
2012-12-20protein level
1 6 4
2012-10-30protein level
1 8 4
2012-10-07protein level
1 8 4
2012-08-24protein level
1 7 4
2012-07-28protein level
1 7 4
2012-06-08protein level
1 8 4
2012-05-07protein level
1 7 4
2012-04-10protein level
1 7 4
2012-01-13protein level
1 6 4
2011-12-20protein level
1 6 4
2011-11-11protein level
1 6 4
2011-08-23protein level
1 6 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75674-1
3 13 0 52955.5461
NX_O75674-2
1 13 0 38688.7196
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-712991,EBI-74634 TOM1  
  .endosomal transport
.protein transport
.endocytosis
.intracellular protein transport
.clathrin binding .extracellular exosome
.membrane
.cytosol
  + 3 more...
2 EBI-712991,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-712991,EBI-297549 VAV2  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.ephrin receptor signaling pathway
  + 17 more...
.metal ion binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.plasma membrane
.cytosol
4 EBI-712991,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
5 EBI-712991,EBI-354967 CLTC  
  .negative regulation of protein localization to plasma membrane
.negative regulation of hyaluronan biosynthetic process
.membrane organization
  + 8 more...
.poly(A) RNA binding
.clathrin light chain binding
.protein kinase binding
  + 2 more...
.clathrin complex
.extracellular exosome
.protein complex
  + 15 more...
6 EBI-712991,EBI-74615 TOLLIP  
  .leukocyte activation
.innate immune response
.protein localization to endosome
  + 8 more...
.Toll-like receptor binding
.kinase binding
.signal transducer activity
.extracellular exosome
.perinuclear region of cytoplasm
.interleukin-1 receptor complex
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites75
bladder200
blood8
bone97
bone marrow20
brain25
connective tissue20
ear62
embryonic tissue42
esophagus148
eye43
heart22
intestine81
kidney118
larynx85
liver43
lung23
lymph node11
mammary gland52
mouth60
muscle18
nerve64
ovary39
pancreas23
parathyroid242
pharynx49
pituitary gland60
placenta17
prostate42
salivary gland148
skin47
spleen18
stomach114
testis29
thymus12
thyroid42
trachea308
uterus73
Health State
TissuesTPM*
normal36
breast (mammary gland) tumor85
chondrosarcoma72
colorectal tumor79
esophageal tumor173
gastrointestinal tumor109
germ cell tumor11
glioma18
head and neck tumor59
kidney tumor29
leukemia21
liver tumor52
lung tumor29
non-neoplasia10
ovarian tumor13
pancreatic tumor28
primitive neuroectodermal tumor of the CNS70
prostate cancer28
retinoblastoma43
skin tumor31
soft tissue/muscle tissue tumor31
uterine tumor88
Developmental Stage
TissuesTPM*
adult37
embryoid body42
blastocyst81
neonate64
fetus28
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.4
adrenal gland19.1
appendix9.2
bone marrow1.3
cerebral cortex6.7
colon39.8
duodenum110.5
esophagus26.5
gallbladder28.4
heart muscle6.6
kidney69.4
liver61.6
lung18.8
lymph node6.2
ovary5.7
pancreas25.6
placenta7.6
prostate35.4
salivary gland29.7
skin21.5
small intestine65.1
spleen4.1
stomach58
testis18.5
thyroid gland71.5
urinary bladder22.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604701, gene) Tom1-like 1; TOM1L1OMIM


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