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> Protein (NX_O75689)
Protein (NX_O75689)
Protein
Gene SymbolADAP1 to neXtProt (NX_O75689)
DescriptionArf-GAP with dual PH domain-containing protein 1
Chromosome7
Location7p22.3 (937540 ~ 995043) to Ensembl
Sequene Features : Isoforms 3, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of GTPase activity
.regulation of GTPase activity
.cell surface receptor signaling pathway
.inositol 1,3,4,5 tetrakisphosphate binding
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.GTPase activator activity
.plasma membrane
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 38 3
2014-09-19protein level
3 25 3
2014-05-27protein level
3 25 3
2014-02-25protein level
1 21 3
2013-12-09protein level
1 17 3
2013-11-01protein level
1 15 3
2013-09-12protein level
1 15 3
2013-08-17protein level
1 15 3
2013-07-15protein level
1 15 3
2013-06-11protein level
1 15 3
2013-02-12protein level
1 8 3
2012-12-20protein level
1 9 3
2012-10-30protein level
1 8 3
2012-10-07protein level
1 8 3
2012-08-24protein level
1 7 3
2012-07-28protein level
1 7 3
2012-06-08protein level
1 11 3
2012-05-07protein level
1 11 3
2012-04-10protein level
1 11 3
2012-01-13protein level
1 7 3
2011-12-20protein level
1 7 3
2011-11-11protein level
1 7 3
2011-08-23protein level
1 7 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75689-1
2 15 1 43367.6858
NX_O75689-2
4 15 1 44907.3719
NX_O75689-3
1 14 1 35330.6703
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-714732,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
2 EBI-714732,EBI-739789 DVL3  
  .positive regulation of canonical Wnt signaling pathway
.planar cell polarity pathway involved in neural tube closure
.cochlea morphogenesis
  + 12 more...
.protein heterodimerization activity
.beta-catenin binding
.frizzled binding
  + 2 more...
.cytosol
3 EBI-714732,EBI-742426 SDCBP2  
  .intracellular transport
.intracellular signal transduction
.nervous system development
.protein heterodimerization activity
.protein homodimerization activity
.protein C-terminus binding
.extracellular exosome
.plasma membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites50
blood40
bone13
brain53
cervix41
connective tissue6
esophagus49
eye4
heart11
intestine94
kidney18
liver24
lung5
lymph node77
mammary gland6
nerve64
ovary19
pancreas32
pharynx24
placenta10
prostate5
spleen56
stomach31
testis4
thymus12
uterus8
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor115
esophageal tumor57
gastrointestinal tumor84
glioma27
kidney tumor14
leukemia31
liver tumor10
lung tumor19
lymphoma13
non-neoplasia31
pancreatic tumor66
primitive neuroectodermal tumor of the CNS86
uterine tumor11
Developmental Stage
TissuesTPM*
adult22
fetus16
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.1
adrenal gland4.9
appendix12.3
bone marrow12.9
cerebral cortex51.6
colon51.8
duodenum35.1
esophagus10.5
gallbladder14
heart muscle6.5
kidney17.9
liver1.8
lung13.6
lymph node6.8
ovary1
pancreas8.6
placenta4.3
prostate3.9
salivary gland4.9
skin4.1
small intestine39.9
spleen11.9
stomach30.9
testis2.1
thyroid gland12.6
urinary bladder13
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonLow
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisLow
fallopian tubeLow
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
nasopharynxMedium
pancreasLow
parathyroid glandLow
placentaMedium
prostateLow
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleLow
skin 1Low
small intestineLow
soft tissue 1Low
soft tissue 2Low
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608114, gene) Centaurin, alpha-1; CENTA1OMIM


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