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> Protein (NX_O75716)
Protein (NX_O75716)
Protein
Gene SymbolSTK16 to neXtProt (NX_O75716)
DescriptionSerine/threonine-protein kinase 16
Chromosome2
Location2q35 (220110177 ~ 220115059) to Ensembl
Sequene Features : Isoforms 1, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 33 7
2014-09-19protein level
1 26 7
2014-05-27protein level
1 26 7
2014-02-25protein level
1 26 7
2013-12-09protein level
1 17 7
2013-11-01protein level
1 17 6
2013-09-12protein level
1 17 6
2013-08-17protein level
1 17 6
2013-07-15protein level
1 12 6
2013-06-11protein level
1 12 6
2013-02-12protein level
1 5 6
2012-12-20protein level
1 7 6
2012-10-30protein level
1 7 6
2012-10-07protein level
1 7 6
2012-08-24protein level
1 7 6
2012-07-28protein level
1 7 6
2012-06-08protein level
1 15 6
2012-05-07protein level
1 15 6
2012-04-10protein level
1 15 6
2012-01-13protein level
1 15 6
2011-12-20protein level
1 15 6
2011-11-11protein level
1 15 6
2011-08-23protein level
1 15 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75716-1
15 0 0 34633.4651
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-749295,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
2 EBI-749295,EBI-748171 CRX  
  .retina development in camera-type eye
.response to stimulus
.positive regulation of photoreceptor cell differentiation
  + 5 more...
.leucine zipper domain binding
.nuclear hormone receptor binding
.sequence-specific DNA binding transcription factor activity
  + 3 more...
.transcription factor complex
.nucleus
3 EBI-749295,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
4 EBI-749295,EBI-744798 TRAF3IP2  
  .immunoglobulin secretion
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.intracellular signal transduction
  + 3 more...
.N/A .N/A
5 EBI-749295,EBI-743414 EFEMP2  
  .extracellular matrix organization .calcium ion binding
.extracellular matrix structural constituent
.extracellular exosome
.vesicle
.basement membrane
.extracellular region
6 EBI-749295,EBI-2902468 SKIL  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.response to growth factor
  + 19 more...
.SMAD binding
.protein complex binding
.protein domain specific binding
  + 4 more...
.protein complex
.PML body
.cytoplasm
  + 3 more...
7 EBI-749295,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
8 EBI-749295,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
9 EBI-749295,EBI-744831 RPIA  
  .small molecule metabolic process
.pentose-phosphate shunt, non-oxidative branch
.pentose-phosphate shunt
.carbohydrate metabolic process
.monosaccharide binding
.ribose-5-phosphate isomerase activity
.intracellular membrane-bounded organelle
.cytosol
10 EBI-749295,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
11 EBI-749295,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
12 EBI-749295,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
13 EBI-749295,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
14 EBI-749295,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
15 EBI-749295,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
16 EBI-749295,EBI-6509505 INCA1  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleus
17 EBI-749295,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
18 EBI-749295,EBI-2505861 TNFAIP1  
  .protein homooligomerization
.positive regulation of DNA replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 8 more...
.GTP-Rho binding .Cul3-RING ubiquitin ligase complex
.endosome
.cytoplasm
.nucleolus
19 EBI-749295,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
20 EBI-749295,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
21 EBI-749295,EBI-2349927 EFHC2  
  .N/A .calcium ion binding .N/A
22 EBI-749295,EBI-2801965 MIIP  
  .N/A .N/A .N/A
23 EBI-749295,EBI-3957672 KRTAP26-1  
  .N/A .N/A .intermediate filament
24 EBI-749295,EBI-742002 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
25 EBI-749295,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
26 EBI-749295,EBI-746118 RFX6  
  .pancreatic epsilon cell differentiation
.regulation of insulin secretion
.positive regulation of transcription from RNA polymerase II promoter
  + 7 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.nucleus
27 EBI-749295,EBI-743960 KCTD17  
  .protein homooligomerization .identical protein binding .N/A
28 EBI-749295,EBI-751290 PCSK5  
  .embryonic skeletal system development
.embryonic digestive tract development
.neurotrophin TRK receptor signaling pathway
  + 15 more...
.peptide binding
.peptidase activity
.serine-type endopeptidase activity
.secretory granule
.integral component of membrane
.Golgi lumen
  + 2 more...
29 EBI-749295,EBI-3952284 DNAJA3  
  .skeletal muscle acetylcholine-gated channel clustering
.negative regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 23 more...
.chaperone binding
.unfolded protein binding
.NF-kappaB binding
  + 5 more...
.postsynaptic membrane
.intracellular membrane-bounded organelle
.mitochondrial nucleoid
  + 8 more...
30 EBI-749295,EBI-750451 ALS2CR12  
  .regulation of GTPase activity .N/A .sperm flagellum
.sperm fibrous sheath
.outer dense fiber
31 EBI-749295,EBI-722877 TCF12  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of neuron differentiation
.muscle organ development
  + 2 more...
.E-box binding
.protein heterodimerization activity
.SMAD binding
  + 7 more...
.RNA polymerase II transcription factor complex
.cytoplasm
.nucleus
.nuclear chromatin
32 EBI-749295,EBI-10189448 KCTD14  
  .protein homooligomerization .N/A .N/A
33 EBI-749295,EBI-740897 NIF3L1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of transcription, DNA-templated
.neuron differentiation
.identical protein binding
.transcription factor binding
.mitochondrion
.cytoplasm
.nucleus
34 EBI-749295,EBI-750734 PLSCR3  
  .cellular response to lipopolysaccharide
.cholesterol homeostasis
.glucose homeostasis
  + 2 more...
.calcium-dependent protein binding
.phospholipid scramblase activity
.calcium ion binding
.mitochondrial membrane
.integral component of membrane
.plasma membrane
35 EBI-749295,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
36 EBI-749295,EBI-719554 DRG1  
  .multicellular organismal development
.transcription, DNA-templated
.identical protein binding
.transcription factor binding
.GTP binding
.membrane
.polysome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
blood106
bone55
bone marrow20
brain32
cervix61
connective tissue13
embryonic tissue37
esophagus99
eye9
heart11
intestine51
kidney52
liver24
lung26
lymph361
lymph node22
mammary gland26
mouth30
muscle28
nerve64
ovary9
pancreas4
parathyroid97
pharynx24
placenta31
prostate31
skin52
spleen18
stomach10
testis36
thymus75
thyroid42
tonsil58
trachea19
uterus30
vascular19
Health State
TissuesTPM*
normal33
adrenal tumor79
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma48
colorectal tumor53
esophageal tumor115
gastrointestinal tumor16
germ cell tumor22
glioma37
head and neck tumor29
kidney tumor29
leukemia95
liver tumor41
lung tumor19
lymphoma221
ovarian tumor13
primitive neuroectodermal tumor of the CNS110
prostate cancer28
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor44
Developmental Stage
TissuesTPM*
adult40
embryoid body42
blastocyst48
fetus41
infant85
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.5
adrenal gland19.2
appendix20
bone marrow19.7
cerebral cortex14.2
colon27.3
duodenum23.6
esophagus20.6
gallbladder22
heart muscle16.4
kidney26.8
liver21
lung16.7
lymph node27.9
ovary20.5
pancreas15.6
placenta14.6
prostate18
salivary gland19.5
skin15.6
small intestine21
spleen21
stomach24.1
testis26.7
thyroid gland29.2
urinary bladder23.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastHigh
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleLow
kidneyLow
lateral ventricleLow
liverMedium
lungLow
nasopharynxHigh
oral mucosaHigh
pancreasMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1High
skin 2High
small intestineMedium
stomach 1Medium
stomach 2Medium
testisLow
thyroid glandLow
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604719, gene) Serine/threonine protein kinase 16; STK16OMIM


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