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> Protein (NX_O75771)
Protein (NX_O75771)
Protein
Gene SymbolRAD51D to neXtProt (NX_O75771)
DescriptionDNA repair protein RAD51 homolog 4
Chromosome17
Location17q12 (33426811 ~ 33448541) to Ensembl
Sequene Features : Isoforms 8, Variants 57, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.strand invasion
.reciprocal meiotic recombination
.DNA repair
  + 2 more...
.gamma-tubulin binding
.DNA-dependent ATPase activity
.ATP binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.centrosome
.cytoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 57 0
2014-09-19protein level
8 53 0
2014-05-27protein level
8 52 0
2014-02-25protein level
8 51 0
2013-12-09protein level
8 33 0
2013-11-01protein level
8 33 0
2013-09-12protein level
8 33 0
2013-08-17protein level
8 33 0
2013-07-15protein level
8 27 0
2013-06-11protein level
8 27 0
2013-02-12protein level
8 17 0
2012-12-20protein level
8 18 0
2012-10-30protein level
8 22 0
2012-10-07protein level
8 22 0
2012-08-24protein level
8 17 0
2012-07-28protein level
8 17 0
2012-06-08protein level
8 6 0
2012-05-07protein level
8 6 0
2012-04-10protein level
7 6 0
2012-01-13protein level
7 6 0
2011-12-20protein level
7 6 0
2011-11-11protein level
7 6 0
2011-08-23protein level
7 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75771-1
0 16 0 35027.2034
NX_O75771-2
0 2 0 5383.8335
NX_O75771-3
0 10 0 23302.1569
NX_O75771-4
0 13 0 30174.8226
NX_O75771-5
1 15 0 35191.2706
NX_O75771-6
1 4 0 12666.5466
NX_O75771-7
1 9 0 22959.892
NX_O75771-8
3 14 0 36991.0692
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1055693,EBI-2824089 RAD51B  
  .positive regulation of G2/M transition of mitotic cell cycle
.blood coagulation
.reciprocal meiotic recombination
  + 3 more...
.DNA-dependent ATPase activity
.ATP binding
.single-stranded DNA binding
  + 2 more...
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.replication fork
.nucleoplasm
.nucleus
2 EBI-1055693,EBI-2267048 RAD51C  
  .positive regulation of G2/M transition of mitotic cell cycle
.blood coagulation
.spermatogenesis
  + 8 more...
.crossover junction endodeoxyribonuclease activity
.DNA-dependent ATPase activity
.ATP binding
.DNA binding
.perinuclear region of cytoplasm
.Rad51C-XRCC3 complex
.Rad51B-Rad51C-Rad51D-XRCC2 complex
  + 5 more...
3 EBI-1055693,EBI-3918457 XRCC2  
  .regulation of fibroblast apoptotic process
.centrosome organization
.positive regulation of neurogenesis
  + 11 more...
.DNA-dependent ATPase activity
.ATP binding
.DNA binding
.Rad51B-Rad51C-Rad51D-XRCC2 complex
.centrosome
.cytoplasm
.replication fork
4 EBI-1055693,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
5 EBI-1055693,EBI-621372 BLM  
  .cellular response to camptothecin
.cellular response to hydroxyurea
.cellular response to ionizing radiation
  + 25 more...
.G-quadruplex DNA binding
.ATP-dependent 3'-5' DNA helicase activity
.annealing helicase activity
  + 9 more...
.pronucleus
.PML body
.nuclear matrix
  + 8 more...
6 EBI-1055693,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
7 EBI-1055693,EBI-5281637 SWSAP1  
  .protein stabilization
.double-strand break repair via homologous recombination
.ATPase activity
.single-stranded DNA binding
.Shu complex
.nucleus
8 EBI-1055693,EBI-946029 C1orf94  
  .N/A .N/A .N/A
9 EBI-1055693,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
10 EBI-1055693,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
11 EBI-1055693,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
12 EBI-1055693,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
13 EBI-1055693,EBI-3957793 PRDM14  
  .homeostasis of number of cells within a tissue
.regulation of DNA methylation
.negative regulation of fibroblast growth factor receptor signaling pathway
  + 11 more...
.metal ion binding
.methyltransferase activity
.DNA binding
.nucleoplasm
14 EBI-1055693,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
15 EBI-1055693,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
bladder33
blood40
bone27
bone marrow20
brain18
cervix41
connective tissue13
embryonic tissue18
heart11
intestine12
kidney23
liver9
lung8
lymph node11
mammary gland6
mouth30
pancreas18
placenta17
prostate10
skin9
spleen37
testis22
thymus12
thyroid21
uterus21
vascular19
Health State
TissuesTPM*
normal16
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma24
colorectal tumor26
gastrointestinal tumor33
glioma37
head and neck tumor22
kidney tumor14
leukemia52
liver tumor10
non-neoplasia10
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult13
embryoid body28
blastocyst16
fetus17
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.7
adrenal gland4.2
appendix7.3
bone marrow5
cerebral cortex6.3
colon4.8
duodenum4.5
esophagus4.5
gallbladder5.1
heart muscle3.7
kidney5.3
liver2.4
lung5.4
lymph node8
ovary7.2
pancreas2.4
placenta6
prostate5.1
salivary gland3.4
skin4
small intestine4.2
spleen8.5
stomach4.4
testis14
thyroid gland7.7
urinary bladder6.1
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*602954, gene) Rad51, s. cerevisiae, homolog of, d; RAD51DOMIM
2(#614291, phenotype) Breast-ovarian cancer, familial, susceptibility to, 4; BROVCA4OMIM


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