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> Protein (NX_O75791)
Protein (NX_O75791)
Protein
Gene SymbolGRAP2 to neXtProt (NX_O75791)
DescriptionGRB2-related adapter protein 2
Chromosome22
Location22q13.1 (40297086 ~ 40369725) to Ensembl
Sequene Features : Isoforms 2, Variants 49, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.T cell receptor signaling pathway
.innate immune response
.Fc-epsilon receptor signaling pathway
  + 4 more...
.SH3/SH2 adaptor activity .cytosol
.endosome
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 49 5
2014-09-19protein level
2 32 5
2014-05-27protein level
1 30 5
2014-02-25protein level
1 30 5
2013-12-09protein level
1 24 5
2013-11-01protein level
1 24 5
2013-09-12protein level
1 24 5
2013-08-17protein level
1 24 5
2013-07-15protein level
1 18 4
2013-06-11protein level
1 18 4
2013-02-12protein level
1 10 3
2012-12-20protein level
1 12 3
2012-10-30protein level
1 14 3
2012-10-07protein level
1 14 3
2012-08-24protein level
1 14 3
2012-07-28protein level
1 14 3
2012-06-08protein level
1 14 3
2012-05-07protein level
1 9 3
2012-04-10protein level
1 9 3
2012-01-13protein level
1 4 3
2011-12-20protein level
1 4 3
2011-11-11protein level
1 4 3
2011-08-23protein level
1 4 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75791-1
10 7 0 37885.6213
NX_O75791-2
3 7 0 24367.0576
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740418,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
2 EBI-740418,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-740418,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
4 EBI-740418,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
5 EBI-740418,EBI-346946 LCP2  
  .T cell receptor signaling pathway
.cytokine secretion
.positive regulation of protein kinase activity
  + 8 more...
.N/A .cell-cell junction
.cytosol
6 EBI-740418,EBI-724478 PTPN23  
  .positive regulation of early endosome to late endosome transport
.positive regulation of adherens junction organization
.positive regulation of homophilic cell adhesion
  + 5 more...
.protein kinase binding
.protein tyrosine phosphatase activity
.extracellular exosome
.ciliary basal body
.cytoplasmic membrane-bounded vesicle
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood32
bone marrow41
connective tissue6
esophagus49
heart22
intestine4
liver4
lung2
pharynx24
placenta31
spleen37
testis4
thymus1355
trachea19
Health State
TissuesTPM*
normal10
bladder carcinoma56
leukemia42
non-neoplasia10
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult8
fetus26
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.5
adrenal gland1.1
appendix11.3
bone marrow7.9
colon2.9
duodenum4
esophagus1.7
gallbladder4.6
lung5.7
lymph node22
prostate2.4
salivary gland2.1
skin1.3
small intestine5.2
spleen11.3
stomach5.3
testis3.2
urinary bladder6.5
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowLow
bronchusLow
cerebral cortexLow
colonLow
duodenumLow
gallbladderLow
hippocampusLow
kidneyLow
liverLow
lungMedium
lymph nodeHigh
nasopharynxLow
placentaLow
rectumLow
skin 1Low
small intestineLow
spleenMedium
stomach 1Low
stomach 2Low
testisLow
thyroid glandLow
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604518, gene) Grb2-related adaptor protein 2; GRAP2OMIM


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