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> Protein (NX_O75815)
Protein (NX_O75815)
Protein
Gene SymbolBCAR3 to neXtProt (NX_O75815)
DescriptionBreast cancer anti-estrogen resistance protein 3
Chromosome1
Location1p22.1 (94027347 ~ 94312706) to Ensembl
Sequene Features : Isoforms 3, Variants 118, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to drug
.positive regulation of peptidyl-serine phosphorylation
.small GTPase mediated signal transduction
  + 2 more...
.guanyl-nucleotide exchange factor activity .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 118 12
2014-09-19protein level
3 97 12
2014-05-27protein level
3 97 12
2014-02-25protein level
3 97 10
2013-12-09protein level
3 76 10
2013-11-01protein level
3 75 10
2013-09-12protein level
3 75 10
2013-08-17protein level
3 75 10
2013-07-15protein level
2 54 10
2013-06-11protein level
2 54 10
2013-02-12protein level
2 39 15
2012-12-20protein level
2 39 15
2012-10-30protein level
2 41 15
2012-10-07protein level
2 41 11
2012-08-24protein level
2 35 11
2012-07-28protein level
2 35 11
2012-06-08protein level
2 35 11
2012-05-07protein level
2 35 11
2012-04-10protein level
2 35 11
2012-01-13protein level
2 15 11
2011-12-20protein level
2 15 11
2011-11-11protein level
2 15 11
2011-08-23protein level
2 15 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75815-1
6 35 1 92506.4958
NX_O75815-2
0 27 0 55708.9405
NX_O75815-3
1 35 1 82304.448
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-702336,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
2 EBI-702336,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
3 EBI-702336,EBI-517592 IRS1  
  .positive regulation of glucose import in response to insulin stimulus
.JAK-STAT cascade involved in growth hormone signaling pathway
.phosphatidylinositol-mediated signaling
  + 29 more...
.phosphatidylinositol 3-kinase binding
.SH2 domain binding
.insulin-like growth factor receptor binding
  + 4 more...
.intracellular membrane-bounded organelle
.ciliary basal body
.caveola
  + 5 more...
4 EBI-702336,EBI-2108053 NEDD9  
  .cell division
.actin filament bundle assembly
.regulation of growth
  + 5 more...
.N/A .lamellipodium
.cell cortex
.focal adhesion
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites25
bladder33
blood16
bone55
brain13
cervix41
connective tissue67
embryonic tissue14
eye14
intestine73
kidney56
larynx42
liver43
lung35
lymph node55
mammary gland85
mouth60
ovary29
pancreas14
placenta91
skin14
stomach31
testis11
thyroid85
trachea19
uterus12
Health State
TissuesTPM*
normal33
breast (mammary gland) tumor96
cervical tumor57
chondrosarcoma48
colorectal tumor71
gastrointestinal tumor25
germ cell tumor11
head and neck tumor22
kidney tumor14
leukemia10
liver tumor62
lung tumor29
non-neoplasia31
ovarian tumor52
pancreatic tumor28
primitive neuroectodermal tumor of the CNS47
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult44
embryoid body28
blastocyst16
fetus19
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.9
adrenal gland10.9
appendix7.4
cerebral cortex5.3
colon16.9
duodenum14.5
esophagus9
gallbladder11.6
heart muscle7
kidney17.9
liver8.5
lung10.8
lymph node14.6
ovary11.4
pancreas2.3
placenta24.9
prostate7.1
salivary gland18.4
skin14.5
small intestine14.4
spleen4.8
stomach16.3
testis8.1
thyroid gland11.8
urinary bladder10.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604704, gene) Breast cancer antiestrogen resistance 3; BCAR3OMIM


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