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> Protein (NX_O75886)
Protein (NX_O75886)
Protein
Gene SymbolSTAM2 to neXtProt (NX_O75886)
DescriptionSignal transducing adapter molecule 2
Chromosome2
Location2q23.3 (152973315 ~ 153032506) to Ensembl
Sequene Features : Isoforms 2, Variants 60, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane organization
.negative regulation of epidermal growth factor receptor signaling pathway
.endosomal transport
  + 2 more...
.N/A .intracellular membrane-bounded organelle
.early endosome membrane
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 60 4
2014-09-19protein level
2 43 4
2014-05-27protein level
2 43 4
2014-02-25protein level
2 42 4
2013-12-09protein level
2 32 4
2013-11-01protein level
2 31 3
2013-09-12protein level
2 31 4
2013-08-17protein level
2 31 4
2013-07-15protein level
2 20 1
2013-06-11protein level
2 20 1
2013-02-12protein level
2 8 6
2012-12-20protein level
2 8 6
2012-10-30protein level
2 8 6
2012-10-07protein level
2 8 4
2012-08-24protein level
2 6 4
2012-07-28protein level
2 6 4
2012-06-08protein level
2 9 4
2012-05-07protein level
2 9 4
2012-04-10protein level
2 9 4
2012-01-13protein level
2 6 4
2011-12-20protein level
2 6 4
2011-11-11protein level
2 6 4
2011-08-23protein level
2 6 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75886-1
4 15 2 58127.5588
NX_O75886-2
0 15 1 38345.9882
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-373258,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-373258,EBI-1049822 TIMM8A  
  .chaperone-mediated protein transport
.cellular protein metabolic process
.nervous system development
.protein targeting to mitochondrion
.metal ion binding .mitochondrial intermembrane space
.mitochondrial inner membrane
.mitochondrion
3 EBI-373258,EBI-396676 STAMBP  
  .negative regulation of Ras protein signal transduction
.negative regulation of neuron apoptotic process
.protein deubiquitination
  + 4 more...
.metal ion binding
.protein domain specific binding
.metallopeptidase activity
.ubiquitin-specific protease activity
.extracellular exosome
.cleavage furrow
.plasma membrane
  + 4 more...
4 EBI-373258,EBI-346946 LCP2  
  .T cell receptor signaling pathway
.cytokine secretion
.positive regulation of protein kinase activity
  + 8 more...
.N/A .cell-cell junction
.cytosol
5 EBI-373258,EBI-366017 RIN1  
  .negative regulation of synaptic plasticity
.associative learning
.memory
  + 2 more...
.GTPase activator activity .neuronal cell body
.dendrite
.plasma membrane
  + 2 more...
6 EBI-373258,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
7 EBI-373258,EBI-2875665 ARRDC3  
  .negative regulation of locomotion involved in locomotory behavior
.positive regulation of adrenergic receptor signaling pathway
.fat pad development
  + 5 more...
.beta-3 adrenergic receptor binding .plasma membrane
.endosome
8 EBI-373258,EBI-373552 PLEKHB2  
  .N/A .N/A .recycling endosome membrane
9 EBI-373258,EBI-725647 LITAF  
  .cellular response to lipopolysaccharide
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.negative regulation of NF-kappaB import into nucleus
  + 6 more...
.WW domain binding
.signal transducer activity
.intracellular membrane-bounded organelle
.plasma membrane
.Golgi apparatus
  + 3 more...
10 EBI-373258,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
11 EBI-373258,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
12 EBI-373258,EBI-739890 KLHL42  
  .cell division
.proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of microtubule-based process
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.spindle
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
bone marrow20
brain18
connective tissue26
embryonic tissue28
eye38
heart33
intestine17
kidney4
liver14
lung50
lymph node55
mammary gland33
mouth15
muscle122
ovary59
pancreas42
parathyroid48
placenta31
prostate89
skin18
spleen18
stomach31
testis45
thymus12
trachea77
uterus12
vascular77
Health State
TissuesTPM*
normal36
chondrosarcoma12
colorectal tumor8
gastrointestinal tumor16
head and neck tumor7
leukemia21
liver tumor20
lung tumor9
lymphoma27
non-neoplasia20
ovarian tumor78
pancreatic tumor38
primitive neuroectodermal tumor of the CNS7
prostate cancer105
skin tumor23
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult37
embryoid body28
blastocyst32
fetus35
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.2
adrenal gland13.1
appendix11.5
bone marrow3.6
cerebral cortex10.9
colon14
duodenum12.9
esophagus14.6
gallbladder13.9
heart muscle8.9
kidney14.8
liver7.2
lung13.3
lymph node11.7
ovary14.6
pancreas6.3
placenta11.6
prostate15.4
salivary gland11.9
skin12.2
small intestine14.4
spleen10.2
stomach16.2
testis25.4
thyroid gland20.1
urinary bladder14.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606244, gene) Signal-transducing adaptor molecule 2; STAM2OMIM


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