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> Protein (NX_O75899)
Protein (NX_O75899)
Protein
Gene SymbolGABBR2 to neXtProt (NX_O75899)
DescriptionGamma-aminobutyric acid type B receptor subunit 2
Chromosome9
Location9q22.33 (101050391 ~ 101471479) to Ensembl
Sequene Features : Isoforms 1, Variants 135, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.synaptic transmission
.gamma-aminobutyric acid signaling pathway
.negative regulation of adenylate cyclase activity
.G-protein coupled receptor signaling pathway
.G-protein coupled GABA receptor activity .postsynaptic membrane
.neuron projection
.G-protein coupled receptor heterodimeric complex
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 135 9
2014-09-19protein level
1 101 9
2014-05-27protein level
1 101 9
2014-02-25protein level
1 101 9
2013-12-09protein level
1 91 9
2013-11-01protein level
1 84 9
2013-09-12protein level
1 84 5
2013-08-17protein level
1 84 5
2013-07-15protein level
1 50 5
2013-06-11protein level
1 50 5
2013-02-12protein level
1 19 6
2012-12-20protein level
1 19 6
2012-10-30protein level
1 21 6
2012-10-07protein level
1 21 6
2012-08-24protein level
1 9 6
2012-07-28protein level
1 9 6
2012-06-08protein level
1 13 6
2012-05-07protein level
1 13 6
2012-04-10protein level
1 13 6
2012-01-13protein level
1 17 6
2011-12-20protein level
1 17 6
2011-11-11protein level
1 17 6
2011-08-23protein level
1 17 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75899-1
42 0 0 105753.2991
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-715469,EBI-712251 NSF  
  .Golgi vesicle docking
.ATP metabolic process
.positive regulation of protein catabolic process
  + 10 more...
.metal ion binding
.ATPase activity, coupled
.protein complex binding
  + 6 more...
.extracellular exosome
.dendritic shaft
.postsynaptic density
  + 5 more...
2 EBI-715469,EBI-724156 GABBR1  
  .synaptic transmission
.gamma-aminobutyric acid signaling pathway
.negative regulation of adenylate cyclase activity
.adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
.G-protein coupled GABA receptor activity .postsynaptic membrane
.presynaptic membrane
.G-protein coupled receptor heterodimeric complex
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
brain79
connective tissue6
embryonic tissue4
eye43
kidney9
lung8
muscle9
ovary9
placenta10
skin4
testis2
thyroid21
vascular77
Health State
TissuesTPM*
normal26
adrenal tumor237
germ cell tumor15
glioma46
head and neck tumor7
kidney tumor14
lung tumor9
ovarian tumor13
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult16
embryoid body14
fetus35
infant85
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland3.7
cerebral cortex47.9
testis1.9
thyroid gland1.2
urinary bladder1.3
Tissues
TissuesExpression level
cerebellumHigh
cerebral cortexHigh
colonMedium
hippocampusLow
lateral ventricleMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607340, gene) Gamma-aminobutyric acid b receptor 2; GABBR2OMIM


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