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> Protein (NX_O75909)
Protein (NX_O75909)
Protein
Gene SymbolCCNK to neXtProt (NX_O75909)
DescriptionCyclin-K
Chromosome14
Location14q32.2 (99947506 ~ 100001381) to Ensembl
Sequene Features : Isoforms 4, Variants 35, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
.negative regulation of cell cycle arrest
.cell division
  + 8 more...
.protein kinase binding
.RNA polymerase II carboxy-terminal domain kinase activity
.cyclin-dependent protein serine/threonine kinase activity
.nucleus
.cyclin K-CDK13 complex
.cyclin K-CDK12 complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 35 5
2014-09-19protein level
4 26 5
2014-05-27protein level
4 26 5
2014-02-25protein level
4 26 5
2013-12-09protein level
4 18 5
2013-11-01protein level
4 18 4
2013-09-12protein level
4 18 4
2013-08-17protein level
4 18 4
2013-07-15protein level
4 11 4
2013-06-11protein level
4 11 4
2013-02-12protein level
4 0 16
2012-12-20protein level
4 2 16
2012-10-30protein level
4 2 16
2012-10-07protein level
4 2 5
2012-08-24protein level
4 2 5
2012-07-28protein level
4 2 5
2012-06-08protein level
4 1 5
2012-05-07protein level
4 1 5
2012-04-10protein level
4 1 5
2012-01-13protein level
4 1 5
2011-12-20protein level
4 1 5
2011-11-11protein level
4 1 5
2011-08-23protein level
4 1 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75909-1
1 15 0 41266.7849
NX_O75909-2
2 13 0 40761.4657
NX_O75909-3
0 21 0 64198.4972
NX_O75909-4
1 21 0 66094.4881
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739806,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
2 EBI-739806,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
3 EBI-739806,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
4 EBI-739806,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
5 EBI-739806,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
6 EBI-739806,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone27
bone marrow20
brain15
cervix61
connective tissue26
ear62
embryonic tissue65
eye76
heart22
intestine137
kidney42
liver48
lung26
lymph22
lymph node100
mammary gland79
muscle9
ovary49
pancreas56
placenta7
prostate58
salivary gland49
skin52
stomach62
testis48
thymus25
uterus64
Health State
TissuesTPM*
normal31
breast (mammary gland) tumor75
cervical tumor86
chondrosarcoma36
colorectal tumor231
gastrointestinal tumor92
germ cell tumor18
glioma46
head and neck tumor7
kidney tumor14
liver tumor41
lung tumor38
lymphoma27
non-neoplasia10
ovarian tumor52
pancreatic tumor76
primitive neuroectodermal tumor of the CNS39
prostate cancer48
retinoblastoma64
skin tumor63
soft tissue/muscle tissue tumor71
uterine tumor44
Developmental Stage
TissuesTPM*
adult44
embryoid body85
blastocyst65
fetus28
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.3
adrenal gland17.4
appendix32.3
bone marrow64.4
cerebral cortex15.6
colon29.5
duodenum25.7
esophagus24.3
gallbladder25.8
heart muscle14.9
kidney15.5
liver12.4
lung21.2
lymph node31.4
ovary29
pancreas9.7
placenta23.7
prostate19.4
salivary gland14.9
skin21.8
small intestine26.2
spleen27.6
stomach27.4
testis63.9
thyroid gland24.9
urinary bladder25.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603544, gene) Cyclin k; CCNKOMIM


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