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> Protein (NX_O75912)
Protein (NX_O75912)
Protein
Gene SymbolDGKI to neXtProt (NX_O75912)
DescriptionDiacylglycerol kinase iota
Chromosome7
Location7q33 (137065783 ~ 137531838) to Ensembl
Sequene Features : Isoforms 1, Variants 200, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of Ras protein signal transduction
.intracellular signal transduction
.platelet activation
  + 2 more...
.metal ion binding
.ATP binding
.GTPase inhibitor activity
  + 2 more...
.perinuclear region of cytoplasm
.synapse
.protein complex
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 200 0
2014-09-19protein level
1 152 0
2014-05-27protein level
1 152 0
2014-02-25protein level
1 152 0
2013-12-09protein level
1 135 0
2013-11-01protein level
1 125 0
2013-09-12protein level
1 125 0
2013-08-17protein level
1 125 0
2013-07-15protein level
1 78 0
2013-06-11protein level
1 78 0
2013-02-12protein level
1 23 2
2012-12-20protein level
1 23 2
2012-10-30protein level
1 26 2
2012-10-07protein level
1 26 2
2012-08-24protein level
1 9 2
2012-07-28protein level
1 9 2
2012-06-08protein level
1 10 2
2012-05-07protein level
1 10 2
2012-04-10protein level
1 10 2
2012-01-13protein level
1 13 2
2011-12-20protein level
1 13 2
2011-11-11protein level
1 13 2
2011-08-23protein level
1 13 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75912-1
40 0 2 116922.5141
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1765520,EBI-301270 VHL  
  .cellular response to hypoxia
.negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 10 more...
.ubiquitin protein ligase activity
.enzyme binding
.transcription factor binding
.ubiquitin-protein transferase activity
.intermediate filament cytoskeleton
.VCB complex
.membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain6
connective tissue13
embryonic tissue18
eye19
heart11
kidney4
liver4
placenta3
skin4
testis16
Health State
TissuesTPM*
normal7
chondrosarcoma12
germ cell tumor11
non-neoplasia10
skin tumor7
Developmental Stage
TissuesTPM*
adult5
blastocyst16
fetus16
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.1
cerebral cortex7.2
gallbladder1.5
heart muscle4.3
kidney1.3
testis1.5
thyroid gland32.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604072, gene) Diacylglycerol kinase, iota, 130-kd; DGKIOMIM


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