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> Protein (NX_O75928)
Protein (NX_O75928)
Protein
Gene SymbolPIAS2 to neXtProt (NX_O75928)
DescriptionE3 SUMO-protein ligase PIAS2
Chromosome18
Location18q21.1 (44388353 ~ 44500123) to Ensembl
Sequene Features : Isoforms 3, Variants 73, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of androgen receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 7 more...
.SUMO ligase activity
.androgen receptor binding
.ligase activity
  + 4 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 73 4
2014-09-19protein level
3 50 4
2014-05-27protein level
3 50 5
2014-02-25protein level
3 50 5
2013-12-09protein level
3 40 5
2013-11-01protein level
3 37 5
2013-09-12protein level
3 37 5
2013-08-17protein level
3 37 5
2013-07-15protein level
3 25 3
2013-06-11protein level
3 25 3
2013-02-12protein level
3 13 6
2012-12-20protein level
3 14 6
2012-10-30protein level
3 16 6
2012-10-07protein level
3 16 3
2012-08-24protein level
3 7 3
2012-07-28protein level
3 7 3
2012-06-08protein level
3 9 3
2012-05-07protein level
3 9 3
2012-04-10protein level
3 9 3
2012-01-13protein level
3 9 3
2011-12-20protein level
3 9 3
2011-11-11protein level
3 9 3
2011-08-23protein level
3 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75928-1
2 22 3 68196.5576
NX_O75928-2
3 22 3 63355.2737
NX_O75928-3
2 14 3 45027.5221
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-348555,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
2 EBI-348555,EBI-748961 CCNDBP1  
  .regulation of cell cycle
.cell cycle
.N/A .cytoplasm
.nucleoplasm
.nucleus
3 EBI-348555,EBI-740037 ZBED1  
  .metabolic process .metal ion binding
.transposase activity
.DNA binding
.nuclear chromosome
4 EBI-348555,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
5 EBI-348555,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
6 EBI-348555,EBI-744302 GFAP  
  .long-term synaptic potentiation
.Bergmann glial cell differentiation
.regulation of neurotransmitter uptake
  + 7 more...
.structural constituent of cytoskeleton .astrocyte end-foot
.cell body
.membrane
  + 3 more...
7 EBI-348555,EBI-10200618 MX2  
  .type I interferon signaling pathway
.regulation of cell cycle
.defense response to virus
  + 8 more...
.GTP binding
.GTPase activity
.cytosol
.cytoplasm
.nuclear pore
.nucleus
8 EBI-348555,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
9 EBI-348555,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
10 EBI-348555,EBI-296739 GNB2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of gastrulation
.regulation of establishment of cell polarity
  + 30 more...
.poly(A) RNA binding
.protein homodimerization activity
.SH2 domain binding
  + 10 more...
.IRE1-RACK1-PP2A complex
.extracellular exosome
.perinuclear region of cytoplasm
  + 11 more...
11 EBI-348555,EBI-80168 UBE2I  
  .positive regulation of SUMO transferase activity
.cell division
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 14 more...
.RING-like zinc finger domain binding
.SUMO conjugating enzyme activity
.poly(A) RNA binding
  + 6 more...
.sumoylated E2 ligase complex
.transferase complex
.synapse
  + 7 more...
12 EBI-348555,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
13 EBI-348555,EBI-741200 NAV2  
  .vagus nerve development
.glossopharyngeal nerve development
.optic nerve development
  + 4 more...
.heparin binding
.ATP binding
.helicase activity
.nucleoplasm
.interstitial matrix
14 EBI-348555,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
15 EBI-348555,EBI-746981 TSR2  
  .maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) .N/A .nucleus
16 EBI-348555,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
17 EBI-348555,EBI-3916242 ACY3  
  .small molecule metabolic process
.viral process
.xenobiotic metabolic process
.metal ion binding
.hydrolase activity, acting on ester bonds
.aminoacylase activity
.extracellular exosome
.apical plasma membrane
.cytosol
18 EBI-348555,EBI-3941207 RUFY1  
  .regulation of endocytosis
.endocytosis
.protein transporter activity
.lipid binding
.zinc ion binding
.intracellular membrane-bounded organelle
.early endosome membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bone13
brain28
embryonic tissue56
eye28
kidney23
liver24
lung14
mammary gland46
mouth75
muscle9
ovary49
pancreas9
parathyroid388
pituitary gland60
prostate31
skin18
spleen56
stomach31
testis186
thymus12
thyroid85
tonsil58
uterus21
vascular19
Health State
TissuesTPM*
normal38
breast (mammary gland) tumor21
chondrosarcoma12
gastrointestinal tumor33
germ cell tumor18
glioma9
head and neck tumor67
liver tumor20
lung tumor9
lymphoma41
non-neoplasia20
ovarian tumor65
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
prostate cancer19
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult33
embryoid body57
blastocyst65
neonate32
fetus14
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.3
adrenal gland9.7
appendix7.2
bone marrow5.9
cerebral cortex13.2
colon8.4
duodenum5.7
esophagus7.6
gallbladder10.1
heart muscle10.9
kidney10.1
liver6.4
lung6.7
lymph node8.2
ovary7.6
pancreas4.2
placenta5.1
prostate9.6
salivary gland5.1
skin6.2
small intestine4.7
spleen8.1
stomach6
testis120.7
thyroid gland15.6
urinary bladder9.3
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*603567, gene) Protein inhibitor of activated stat2; PIAS2OMIM


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