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> Protein (NX_O75934)
Protein (NX_O75934)
Protein
Gene SymbolBCAS2 to neXtProt (NX_O75934)
DescriptionPre-mRNA-splicing factor SPF27
Chromosome1
Location1p13.2 (115110178 ~ 115124260) to Ensembl
Sequene Features : Isoforms 1, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.RNA splicing, via transesterification reactions
.N/A .cell junction
.nucleolus
.spliceosomal complex
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 25 1
2014-09-19protein level
1 18 1
2014-05-27protein level
1 18 1
2014-02-25protein level
1 18 1
2013-12-09protein level
1 15 1
2013-11-01protein level
1 15 1
2013-09-12protein level
1 15 1
2013-08-17protein level
1 15 1
2013-07-15protein level
1 10 1
2013-06-11protein level
1 10 1
2013-02-12protein level
1 3 1
2012-12-20protein level
1 3 1
2012-10-30protein level
1 3 1
2012-10-07protein level
1 3 1
2012-08-24protein level
1 3 1
2012-07-28protein level
1 3 1
2012-06-08protein level
1 5 1
2012-05-07protein level
1 5 1
2012-04-10protein level
1 5 1
2012-01-13protein level
1 5 1
2011-12-20protein level
1 5 1
2011-11-11protein level
1 5 1
2011-08-23protein level
1 5 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75934-1
13 0 0 26114.924
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1050106,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
2 EBI-1050106,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
3 EBI-1050106,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
4 EBI-1050106,EBI-745226 AIMP2  
  .Type II pneumocyte differentiation
.positive regulation of protein ubiquitination
.gene expression
  + 3 more...
.N/A .membrane
.cytosol
.nucleus
5 EBI-1050106,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
6 EBI-1050106,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
7 EBI-1050106,EBI-538479 PRPF8  
  .gene expression
.RNA splicing
.mRNA processing
  + 3 more...
.pre-mRNA intronic binding
.K63-linked polyubiquitin binding
.poly(A) RNA binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear speck
.membrane
  + 3 more...
8 EBI-1050106,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
9 EBI-1050106,EBI-395746 PRPF19  
  .signal transduction involved in DNA damage checkpoint
.protein K63-linked ubiquitination
.positive regulation of astrocyte differentiation
  + 14 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin-ubiquitin ligase activity
.ligase activity
.catalytic step 2 spliceosome
.U2-type catalytic step 1 spliceosome
.site of double-strand break
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
bladder569
blood65
bone83
bone marrow369
brain95
connective tissue40
embryonic tissue70
esophagus99
eye38
heart22
intestine43
kidney61
larynx42
liver102
lung53
lymph node55
mammary gland33
muscle18
ovary9
pancreas28
parathyroid291
pharynx220
pituitary gland60
placenta24
prostate63
salivary gland345
skin52
stomach52
testis55
thymus12
uterus43
vascular19
Health State
TissuesTPM*
normal48
adrenal tumor79
bladder carcinoma966
breast (mammary gland) tumor53
chondrosarcoma84
colorectal tumor35
esophageal tumor115
gastrointestinal tumor33
germ cell tumor75
glioma158
head and neck tumor7
leukemia232
liver tumor62
lung tumor29
non-neoplasia10
pancreatic tumor28
prostate cancer48
retinoblastoma21
skin tumor87
soft tissue/muscle tissue tumor55
uterine tumor55
Developmental Stage
TissuesTPM*
adult56
embryoid body71
blastocyst32
fetus23
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.7
adrenal gland42.4
appendix27.8
bone marrow47.2
cerebral cortex41.6
colon31.8
duodenum23
esophagus33.7
gallbladder34.6
heart muscle32.5
kidney35.9
liver26.7
lung26.1
lymph node34.6
ovary32.7
pancreas13.1
placenta26.7
prostate34.6
salivary gland21.2
skin25.4
small intestine23.5
spleen22.3
stomach26
testis31
thyroid gland42.7
urinary bladder40.9
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*605783, gene) Breast carcinoma amplified sequence 2; BCAS2OMIM


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