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> Protein (NX_O75970)
Protein (NX_O75970)
Protein
Gene SymbolMPDZ to neXtProt (NX_O75970)
DescriptionMultiple PDZ domain protein
Chromosome9
Location9p23 (13105703 ~ 13279589) to Ensembl
Sequene Features : Isoforms 4, Variants 286, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.myelination
.viral process
.cell adhesion
.protein C-terminus binding .postsynaptic membrane
.Schmidt-Lanterman incisure
.cytoplasmic vesicle
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 286 10
2014-09-19protein level
4 228 10
2014-05-27protein level
4 228 10
2014-02-25protein level
4 228 10
2013-12-09protein level
4 153 10
2013-11-01protein level
4 152 9
2013-09-12protein level
4 152 9
2013-08-17protein level
4 152 9
2013-07-15protein level
3 89 9
2013-06-11protein level
3 89 9
2013-02-12protein level
3 51 15
2012-12-20protein level
3 46 15
2012-10-30protein level
3 77 15
2012-10-07protein level
3 77 5
2012-08-24protein level
3 61 5
2012-07-28protein level
3 61 5
2012-06-08protein level
3 63 5
2012-05-07protein level
3 63 5
2012-04-10protein level
3 63 5
2012-01-13protein level
3 35 5
2011-12-20protein level
3 35 5
2011-11-11protein level
3 35 5
2011-08-23protein level
3 35 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O75970-1
0 95 1 221480.0365
NX_O75970-2
0 93 1 218371.457
NX_O75970-3
0 93 1 217779.1579
NX_O75970-5
0 91 1 214670.5784
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-821405,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-821405,EBI-6266935 SSTR3  
  .cellular response to estradiol stimulus
.cellular response to glucocorticoid stimulus
.regulation of insulin secretion
  + 12 more...
.neuropeptide binding
.somatostatin receptor activity
.ciliary membrane
.neuron projection
.nonmotile primary cilium
  + 3 more...
3 EBI-821405,EBI-7590304 OR2AG1  
  .detection of chemical stimulus involved in sensory perception of smell
.sensory perception of smell
.G-protein coupled receptor signaling pathway
.olfactory receptor activity
.G-protein coupled receptor activity
.integral component of membrane
.plasma membrane
4 EBI-821405,EBI-2652984 PLEKHA1  
  .cellular response to hydrogen peroxide
.face morphogenesis
.palate development
  + 14 more...
.phosphatidylinositol-3,4-bisphosphate binding
.PDZ domain binding
.extracellular exosome
.ruffle membrane
.plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
bone27
brain61
cervix20
connective tissue6
ear62
embryonic tissue79
esophagus49
eye47
heart89
intestine8
kidney47
liver112
lung14
mammary gland125
mouth30
muscle56
nerve257
ovary19
pancreas9
parathyroid97
pituitary gland121
placenta17
prostate21
skin18
spleen18
testis20
thymus25
thyroid42
trachea38
umbilical cord145
uterus47
vascular77
Health State
TissuesTPM*
normal49
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma24
colorectal tumor8
esophageal tumor57
germ cell tumor18
glioma18
head and neck tumor22
kidney tumor14
liver tumor93
lung tumor9
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor7
uterine tumor66
Developmental Stage
TissuesTPM*
adult48
embryoid body128
blastocyst32
neonate64
fetus46
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.7
adrenal gland13
appendix6.5
cerebral cortex26.1
colon5.9
duodenum3.1
esophagus8.8
gallbladder15.5
heart muscle25.8
kidney17.8
liver61.8
lung14.2
lymph node5.1
ovary27.9
pancreas2.9
placenta21
prostate19.4
salivary gland4.7
skin3.4
small intestine4.2
spleen12
stomach3.1
testis14.4
thyroid gland12.7
urinary bladder13.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603785, gene) Multiple pdz domain protein; MPDZOMIM


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