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> Protein (NX_O76003)
Protein (NX_O76003)
Protein
Gene SymbolGLRX3 to neXtProt (NX_O76003)
DescriptionGlutaredoxin-3
Chromosome10
Location10q26.3 (131934663 ~ 131982785) to Ensembl
Sequene Features : Isoforms 1, Variants 41, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 41 3
2014-09-19protein level
1 35 3
2014-05-27protein level
1 35 3
2014-02-25protein level
1 35 3
2013-12-09protein level
1 25 3
2013-11-01protein level
1 24 2
2013-09-12protein level
1 24 2
2013-08-17protein level
1 24 2
2013-07-15protein level
1 18 2
2013-06-11protein level
1 18 2
2013-02-12protein level
1 8 1
2012-12-20protein level
1 8 1
2012-10-30protein level
1 10 1
2012-10-07protein level
1 10 1
2012-08-24protein level
1 10 1
2012-07-28protein level
1 10 1
2012-06-08protein level
1 15 1
2012-05-07protein level
1 11 1
2012-04-10protein level
1 11 1
2012-01-13protein level
1 11 1
2011-12-20protein level
1 11 1
2011-11-11protein level
1 11 1
2011-08-23protein level
1 11 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_O76003-1
17 0 0 37408.1274
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-374781,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
2 EBI-374781,EBI-947402 MAPKBP1  
  .N/A .N/A .N/A
3 EBI-374781,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
4 EBI-374781,EBI-1052678 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
5 EBI-374781,EBI-358174 STAU1  
  .positive regulation by virus of viral protein levels in host cell
.positive regulation of viral genome replication
.intracellular mRNA localization
.poly(A) RNA binding
.double-stranded RNA binding
.extracellular exosome
.cell body
.neuronal cell body
  + 9 more...
6 EBI-374781,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
7 EBI-374781,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
8 EBI-374781,EBI-747754 GRN  
  .positive regulation of epithelial cell proliferation
.embryo implantation
.signal transduction
.blastocyst hatching
.poly(A) RNA binding
.growth factor activity
.extracellular exosome
.intracellular membrane-bounded organelle
.mitochondrion
.extracellular space
9 EBI-374781,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
10 EBI-374781,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
11 EBI-374781,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
12 EBI-374781,EBI-10217483 KRTAP10-11  
  .N/A .N/A .keratin filament
13 EBI-374781,EBI-374762 PRKCQ  
  .positive regulation of T-helper 2 cell activation
.positive regulation of T-helper 17 type immune response
.regulation of platelet aggregation
  + 26 more...
.metal ion binding
.ATP binding
.ubiquitin-protein transferase activity
  + 2 more...
.plasma membrane
.cytosol
.immunological synapse
14 EBI-374781,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
15 EBI-374781,EBI-744027 CBLB  
  .negative regulation of T cell receptor signaling pathway
.negative regulation of alpha-beta T cell proliferation
.positive regulation of protein catabolic process
  + 7 more...
.ligase activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
16 EBI-374781,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
17 EBI-374781,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
18 EBI-374781,EBI-743729 UGP2  
  .cellular glucuronidation
.small molecule metabolic process
.glucose 1-phosphate metabolic process
  + 6 more...
.metal ion binding
.identical protein binding
.pyrimidine ribonucleotide binding
  + 2 more...
.extracellular exosome
.cytosol
.nucleus
19 EBI-374781,EBI-10246750 LCE2D  
  .keratinization .N/A .N/A
20 EBI-374781,EBI-750511 CIAPIN1  
  .small molecule metabolic process
.negative regulation of apoptotic process
.hemopoiesis
  + 2 more...
.2 iron, 2 sulfur cluster binding
.metal ion binding
.electron carrier activity
.mitochondrial intermembrane space
.cytoplasm
.nucleolus
.nucleoplasm
21 EBI-374781,EBI-10250562 KRTAP5-6  
  .N/A .N/A .keratin filament
22 EBI-374781,EBI-2841978 ZNF544  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
23 EBI-374781,EBI-7134667 MOXD1  
  .N/A .oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
.copper ion binding
.integral component of membrane
.endoplasmic reticulum membrane
24 EBI-374781,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
25 EBI-374781,EBI-10260688 TMEM25  
  .N/A .N/A .integral component of membrane
.plasma membrane
.extracellular region
26 EBI-374781,EBI-5235829 TRIM42  
  .N/A .zinc ion binding .intracellular
27 EBI-374781,EBI-5658292 ZBTB44  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
28 EBI-374781,EBI-751290 PCSK5  
  .embryonic skeletal system development
.embryonic digestive tract development
.neurotrophin TRK receptor signaling pathway
  + 15 more...
.peptide binding
.peptidase activity
.serine-type endopeptidase activity
.secretory granule
.integral component of membrane
.Golgi lumen
  + 2 more...
29 EBI-374781,EBI-10292253 OLFM3  
  .eye photoreceptor cell development .N/A .synapse
.alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
.cell junction
  + 2 more...
30 EBI-374781,EBI-6658697 ALKBH3  
  .oxidative single-stranded DNA demethylation
.cell proliferation
.DNA dealkylation involved in DNA repair
.DNA repair
.cytosine C-5 DNA demethylase activity
.DNA-N1-methyladenine dioxygenase activity
.L-ascorbic acid binding
.ferrous iron binding
.mitochondrion
.cytoplasm
.nucleoplasm
.nucleus
31 EBI-374781,EBI-357275 PFDN5  
  .negative regulation of canonical Wnt signaling pathway
.retina development in camera-type eye
.'de novo' posttranslational protein folding
  + 4 more...
.transcription corepressor activity .prefoldin complex
.cytoplasm
.nucleus
32 EBI-374781,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
33 EBI-374781,EBI-7239117 SOX7  
  .regulation of canonical Wnt signaling pathway
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 3 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding transcription factor activity
.cytoplasm
.nucleoplasm
.nucleus
34 EBI-374781,EBI-743265 ZNF426  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
35 EBI-374781,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
36 EBI-374781,EBI-10302392 KRTAP4-11  
  .N/A .N/A .keratin filament
37 EBI-374781,EBI-10302547 KRTAP4-7  
  .hair cycle
.aging
.N/A .keratin filament
38 EBI-374781,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
39 EBI-374781,EBI-2341518 TRIM36  
  .regulation of cell cycle
.acrosome reaction
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.extracellular exosome
.cytoskeleton
.acrosomal vesicle
40 EBI-374781,EBI-8638992 FAM118A  
  .N/A .N/A .integral component of membrane
41 EBI-374781,EBI-723153 CGGBP1  
  .negative regulation of transcription from RNA polymerase II promoter .double-stranded DNA binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
42 EBI-374781,EBI-2688184 ZNF148  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription, DNA-templated
.substantia nigra development
  + 6 more...
.metal ion binding
.sequence-specific DNA binding
.double-stranded DNA binding
  + 2 more...
.Golgi apparatus
.nucleoplasm
43 EBI-374781,EBI-1049556 BOLA1  
  .N/A .N/A .mitochondrion
.extracellular region
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland121
ascites100
bladder234
blood40
bone111
bone marrow164
brain62
cervix226
connective tissue147
embryonic tissue126
esophagus99
eye95
heart89
intestine77
kidney61
larynx42
liver53
lung38
lymph67
lymph node33
mammary gland79
mouth30
muscle84
nerve128
ovary39
pancreas60
pharynx49
placenta52
prostate42
salivary gland49
skin99
stomach31
testis112
thymus25
thyroid64
tonsil58
trachea57
umbilical cord145
uterus77
vascular58
Health State
TissuesTPM*
normal62
adrenal tumor79
bladder carcinoma398
breast (mammary gland) tumor118
cervical tumor144
chondrosarcoma108
colorectal tumor71
esophageal tumor115
gastrointestinal tumor59
germ cell tumor64
glioma65
head and neck tumor44
kidney tumor58
leukemia84
liver tumor52
lung tumor38
lymphoma55
non-neoplasia31
ovarian tumor39
pancreatic tumor66
primitive neuroectodermal tumor of the CNS55
prostate cancer28
retinoblastoma129
skin tumor111
soft tissue/muscle tissue tumor239
uterine tumor55
Developmental Stage
TissuesTPM*
adult73
embryoid body157
blastocyst113
neonate64
fetus78
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.2
adrenal gland30
appendix31.1
bone marrow20.6
cerebral cortex17.3
colon25.8
duodenum24.5
esophagus36.6
gallbladder21.1
heart muscle28.2
kidney25.2
liver16.1
lung18.9
lymph node34.8
ovary17.2
pancreas13.5
placenta25.5
prostate22.1
salivary gland16.9
skin27.1
small intestine21.2
spleen22
stomach27.1
testis42.4
thyroid gland23.4
urinary bladder29.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612754, gene) Glutaredoxin 3; GLRX3OMIM


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