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> Protein (NX_O76015)
Protein (NX_O76015)
Gene SymbolKRT38 to neXtProt (NX_O76015)
DescriptionKeratin, type I cuticular Ha8
Location17q21.2 (39592698 ~ 39597173) to Ensembl
Sequene Features : Isoforms 1, Variants 79, PTMsto neXtProt Sequence Features
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .structural molecule activity .extracellular exosome
.intermediate filament
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 79 0
2014-09-19protein level
1 59 0
2014-05-27protein level
1 59 1
2014-02-25protein level
1 58 1
2013-12-09protein level
1 42 1
2013-11-01protein level
1 40 1
2013-09-12protein level
1 40 1
2013-08-17protein level
1 40 1
2013-07-15protein level
1 32 1
2013-06-11protein level
1 32 1
2013-02-12protein level
1 18 0
2012-12-20protein level
1 17 0
2012-10-30protein level
1 21 0
2012-10-07protein level
1 21 0
2012-08-24transcript level
1 17 0
2012-07-28transcript level
1 17 0
2012-06-08transcript level
1 18 0
2012-05-07transcript level
1 17 0
2012-04-10transcript level
1 17 0
2012-01-13transcript level
1 6 0
2011-12-20transcript level
1 6 0
2011-11-11transcript level
1 6 0
2011-08-23transcript level
1 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
9 0 11 50447.2802
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1047263,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
2 EBI-1047263,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
3 EBI-1047263,EBI-751857 MAGEB4  
  .N/A .N/A .N/A
4 EBI-1047263,EBI-374781 GLRX3  
  .cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
5 EBI-1047263,EBI-702198 KRT6A  
  .activation of mitophagy in response to mitochondrial depolarization
.wound healing
.cell differentiation
  + 3 more...
.structural constituent of cytoskeleton .extracellular exosome
.keratin filament
6 EBI-1047263,EBI-740907 KRT6B  
  .ectoderm development .structural constituent of cytoskeleton .extracellular exosome
.keratin filament
7 EBI-1047263,EBI-297852 KRT8  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.cell differentiation involved in embryonic placenta development
  + 5 more...
.scaffold protein binding
.structural molecule activity
.extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 10 more...
8 EBI-1047263,EBI-702187 KRT5  
  .cell junction assembly
.hemidesmosome assembly
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.keratin filament
  + 6 more...
9 EBI-1047263,EBI-717634 ZNF20  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
10 EBI-1047263,EBI-2371606 KRT4  
  .negative regulation of epithelial cell proliferation
.epithelial cell differentiation
.cytoskeleton organization
.structural molecule activity .intermediate filament cytoskeleton
.keratin filament
.cell surface
  + 2 more...
11 EBI-1047263,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
  + 7 more...
12 EBI-1047263,EBI-1247312 KRT2  
  .keratinocyte migration
.keratinocyte proliferation
.keratinocyte activation
  + 2 more...
.structural constituent of cytoskeleton .extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 6 more...
13 EBI-1047263,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.extracellular region
14 EBI-1047263,EBI-2564105 KRT6C  
  .intermediate filament cytoskeleton organization .structural molecule activity .extracellular exosome
.keratin filament
.intermediate filament
15 EBI-1047263,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
16 EBI-1047263,EBI-10211741 GNG10  
  .cellular response to glucagon stimulus
.small molecule metabolic process
.synaptic transmission
  + 3 more...
.signal transducer activity
.GTPase activity
.extracellular exosome
.plasma membrane
.heterotrimeric G-protein complex
17 EBI-1047263,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.A band
.neuromuscular junction
  + 7 more...
18 EBI-1047263,EBI-357745 PSMC5  
  .positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.positive regulation of inclusion body assembly
  + 30 more...
.proteasome-activating ATPase activity
.thyrotropin-releasing hormone receptor binding
.TBP-class protein binding
  + 4 more...
.blood microparticle
.extracellular exosome
.cytosolic proteasome complex
  + 11 more...
19 EBI-1047263,EBI-10221390 KRT83  
  .hair cycle
.epidermis development
.structural molecule activity .keratin filament
.extracellular space
20 EBI-1047263,EBI-741210 C19orf57  
  .multicellular organismal development .N/A .N/A
21 EBI-1047263,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.nuclear speck
  + 2 more...
22 EBI-1047263,EBI-739648 KRT81  
  .N/A .structural molecule activity .keratin filament
.extracellular space
23 EBI-1047263,EBI-6426443 KLHL38  
  .N/A .N/A .N/A
24 EBI-1047263,EBI-2952676 KRT71  
  .intermediate filament organization
.hair follicle morphogenesis
.structural molecule activity .extracellular exosome
.keratin filament
25 EBI-1047263,EBI-2514135 KRT79  
  .N/A .enzyme binding
.structural molecule activity
.extracellular exosome
.keratin filament
26 EBI-1047263,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
27 EBI-1047263,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
28 EBI-1047263,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
29 EBI-1047263,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
30 EBI-1047263,EBI-747505 C1orf216  
  .N/A .N/A .N/A
31 EBI-1047263,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
32 EBI-1047263,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
  + 2 more...
33 EBI-1047263,EBI-744859 ANKRD36BP1  
  .N/A .N/A .N/A
34 EBI-1047263,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
35 EBI-1047263,EBI-2849569 ZFYVE21  
  .N/A .metal ion binding .cytoplasmic membrane-bounded vesicle
.focal adhesion
36 EBI-1047263,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
37 EBI-1047263,EBI-10300934 RHPN1-AS1  
  .N/A .N/A .N/A
38 EBI-1047263,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
39 EBI-1047263,EBI-713401 HMG20B  
  .positive regulation of neuron differentiation
.skeletal muscle cell differentiation
.negative regulation of protein sumoylation
  + 6 more...
.chromatin binding
.DNA binding
40 EBI-1047263,EBI-10320732 CD300A  
  .negative regulation of eosinophil migration
.negative regulation of activation of JAK2 kinase activity
.negative regulation of eosinophil activation
  + 14 more...
.signaling receptor activity
.phosphatidylethanolamine binding
.phosphatidylserine binding
.extracellular exosome
.integral component of membrane
.plasma membrane
41 EBI-1047263,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
Health State
colorectal tumor17
Developmental Stage
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
TumorNumber of patients and Staining levels
breast cancer
cervical cancer
colorectal cancer
endometrial cancer
head and neck cancer
liver cancer
lung cancer
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
No.Disease DescriptionRef.
1(*604542, gene) Keratin 38; KRT38OMIM

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